Professor. Our research investigates the molecular mechanisms underlying the functioning of mannose 6-phosphate receptors (MPRs) in mammalian cells.
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Professor. Our current work concerns (1) understanding the mechanism by which the Serum Response Factor (SRF) mediates gene expression during early cardiogenesis, and (2) understanding mechanisms controlling the in vivo expression of the SRF gene itself during early development.
Joseph F. Heil, Jr. Professor and Chairman. The group's efforts are currently focused with the posttranslational modification and the subcellular localization of signal transduction proteins, and with stress signaling and the characterization of histidine kinases.
Assistant Professor. Proliferative programs of normal mammalian cells are interfaced with a variety of innate tumor-suppressive mechanisms that can trigger apoptosis or senescence in response to aberrant cell proliferation.
Assistant Professor. Current research in the laboratory is focused on the structural mechanisms of gene transcription and regulation in eukaryotic cells.
Associate Professor. AMP deaminase (AMPD) is a highly regulated enzyme that catalyzes a branchpoint reaction in the ATP catabolic pathway and competes with AMP-preferring cytosolic 5'-nucleotidase (cNT-I) for available substrate
Professor. Aerobic cells may experience oxidative stress damage if their enzymatic and non-enzymatic antioxidant defenses are overwhelmed by reactive oxygen species (ROS) generated by various endogenous and exogenous challenges.
Professor. The two major projects in the laboratory are elucidation of the role of proteinases and proteinase inhibitors in corneal wound healing and corneal ulceration and exploration of the effects of maspin in corneal wound healing and in carcinogenesis.
Professor. Glutathione (L-g-glutamyl-L-cysteinylglycine, GSH), the main non-protein thiol in cells, plays a key role in defense against free radicals, peroxides, and electrophiles.
Associate Professor. A primary focus in the lab is understanding how signaling and adhesion molecules interact with each other to direct the migration and activity of cells involved in immune responses.
Associate Professor. Transcription within a eucaryotic cell is not a process in which RNA polymerase can freely access the DNA for either initiation or elongation of the transcript.
Secondary Faculty. Professor of Pediatric Surgery. Cardioprotection in children undergoing surgery for repair of congenital heart defects, genetic basis of resistance to myocardial ischemia
Professor. Our research interest is to study the structure-function relationship of biologically interesting molecules by using X-ray diffraction methods, one of the most powerful techniques to date to study macromolecular structure.
Secondary Faculty. Assistant Professor of Medicine. Obesity, diabetes and the metabolic syndrome are all characterized by dyslipidemias and inappropriate nutrient utilization.
Assistant Professor. One of the major projects in the lab is focused on small Ras-like GTPases and their involvement in signaling and cancer development.
Secondary Faculty. Professor of Medicine (Gastroenterology). Vitamin B12 (Cobalamin, Cbl) is an essential micronutrient required for red cell formation and a healthy nervous system
Assistant Professor. Our primary research interest is to develop novel technologies for the comprehensive characterization of cellular proteomes in order to better understand protein functions and interactions under normal and disease states.
Secondary Faculty. Director of the Blood Research Institute. The overall goal of the White lab is to understand the signaling pathways that mediate the hemostatic responses of blood platelets.