Kathleen M. Schmainda, PhD
Associate Professor
Department of Radiology
Department of Biophysics
Faculty of the MCW Functional Imaging Research Center
Department of Biophysics
Medical College of Wisconsin
8701 Watertown Plank Road
Milwaukee, WI 53226-0509
Phone: 414-456-4051
Fax: 414-456-6512
Email: kathleen@mcw.edu
Publications
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A primary focus of our laboratory is the development of MRI (magnetic resonance imaging) methods to assess brain tumor angiogenesis and invasion. Angiogenesis is the process of new vessel formation that enables tumors to grow and spread. Invasion describes the process whereby tumor cells enter and spread to other parts of the brain, making brain tumors very difficult to treat.
The methods developed in our laboratory can provide information about the normal brain and tumor's vascular structure, the amount of blood volume in the brain and tumor (cerebral blood volume (CBV)) and the perfusion or delivery of blood to the tumor (cerebral blood flow (CBF)). In addition by using MRI methods capable of measuring the micromolecular movement of tissue water (ie diffusion) we have demonstrated the potential to track tumor progression and possibly invasion.
These vascular and diffusion parameters provide information about the tumor biology, which is not currently available with standard MRI used in clinical practice. Measurement of these parameters holds promise for providing a more complete assessment of the primary tumor, tumor spread and for evaluating novel (eg anti-angiogenic) therapies. Studies performed in our laboratory address issues ranging from characterizing the basic biophysical relationships between the MRI signal and tumor biology to translating these methods into the clinic.
Group Members:
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Rebecca Lund
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Sr. Research Engineer
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414-456-7411
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Eric Paulson
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Graduate Student
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414-456-4593
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Doug Prah
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Graduate Student
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414-456-4593
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Training:
Marquette University, Milwaukee, WI, BSE Biomedical Engineering 1986
MIT, Cambridge, MA, MSEE Electrical Engineering 1989
Harvard-MIT, Cambridge, MA, PhD Medical Engineering 1993
Massachusetts General Hospital, Charlestown, MA Post-doctoral fellowship in MRI 1993-1995
Honors and Awards: (*Indicates student of Dr. Schmainda)
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1989-1990
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Gillette Fellow, Medical Engineering and Medical Physics, Harvard-MIT, Cambridge, MA
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1993-1994
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Sterling Winthrop Fellow, Health Sciences and Technology, Harvard-MIT, Cambridge, MA
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1998
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Featured in Milwaukee Business Journal's 40 under 40
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1999
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American Society of Neuroradiology Meeting, Magna Cum Laude, awarded to "Diffusion Magnetic Resonance Imaging in Stroke: A comparison of spin-echo and FLAIR spin echo diffusion sensitive techniques." JL Ulmer, AT Olson, LL Latour, OB Nordling, KM Donahue.
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2001
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101st Annual Scientific Meeting of American Roentgen Ray Society, Seattle, Washington Scientific Exhibit Gold Medal awarded to: "Physiologic magnetic resonance imaging of the brain: a conceptual approach to contrast mechanisms and measureable physiologic parameters." JL Ulmer, JM Strottmann, RW Prost, KM Schmainda, BB Biswal, LP Mark, DL Daniels.
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2004
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International Society of Magnetic Resonance in Medicine Meeting, Young Investigator Moore Award, awarded to "Intravoxel Distributionof DWI Decay Rates Reveals C6 Glioma Invasion in Rat Brain." *KM Bennett, JS Hyde, SD Rand, R Bennett, HGJ Krouwer, KJ Rebro, KM Schmainda.
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2004
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International Society of Magnetic Resonance in Medicine Meeting, First Place Poster Award, Cancer Imaging and Spectroscopy, awarded to "The Anti-angiogenic Drug, SU11657 Decreases Brain Tumor Size and Normalizes Perfusion as Indicated by DSC-MRI Perfusion Parameters" *CC Quarles, FC Wu, M Darpolor, SD Rand, HGJ Krouwer, KM Schmainda.
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2004
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American Society of Neuroradiology Meeting, Summa Cum Laude, awarded to "Lesion-induced neurovascular uncoupling can mimic cortical reorganization by BOLD fMRI" JL Ulmer, L Hacein-Bey, VP Mathews, EA DeYoe, RW Prost, KM Schmainda, WM Mueller, HGJ Krouwer.
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Grants:
MRI Contrast Agent Methods to Assess Tumor Angiogenesis [3 RO1 CA082500; Schmainda (PI)] is a 5 year award from the National Cancer Institute. The objective of this work is to develop and validate contrast agent MRI methods for the evaluation of tumor angiogenesis and anti-angiogenic therapies. 04/01/07 – 03/30/12
Effects of Chemotherapy on Cognition and Brain Function in Breast Cancer Patients [Bloom (PI)] is a 1 year award from the MCW Cancer Center's State of Wisconsin Tax Check-Off Program and the New Initiative in Breast Cancer Research. The primary goal of this grant is to evaluate with functional maging the cognitive effects of chemotherapy in breast cancer patients. 07/01/07 – 06/30/08
Diffusion MRI to Detect Glioma Invasion [R21 CA109280; Schmainda (PI)] is a 2 year award from the National Cancer Institute. The objective of this work is to develop and validate diffusion-based MRI methods to detect invading glioma cells. 09/01/07 - 08/31/09
Research Support Completed in the last 3 years:
Development of a MRI Method to Measure Breast Tumor Blood Volume: A Sensitive and Specific Indicator of Breast Cancer [Schmainda (PI)] is a 2 year award from the Wisconsin Breast Cancer Showhouse. The primary goal of this grant is to evaluate the feasibility and utility of dynamic susceptibility contrast agent methods to measure breast tumor blood volume. 03/01/06 – 02/28/08
Mito-Q Attentuates DOX-Induced Cardiotoxicity and Potentiates Antitumor Effects: MR imaging and Echoardiography Studies [Kalyanaraman (PI)] is a 2 year award from the Wisconsin Breast Cancer Showhouse. The primary goal of this grant is to evaluate with imaging the effects of Mito-Q. 03/01/06 – 02/28/08
MRI Contrast Agent Methods to Assess Tumor Angiogenesis [RO1 CA082500; Schmainda (PI)] is a 4 year award from the National Cancer Institute. The objective of this work is to develop and validate contrast agent MRI methods for the evaluation of tumor angiogenesis and anti-angiogenic therapies. 4/1/03 – 3/30/07
Facilitating Discovery with Multi-parameter Physiologic Imaging of Brain Tumors is a 2 year award from the Medical College of Wisconsin "Advancing a Healthier Wisconsin" Program. The primary goal of this grant is to facilitate the translation of advanced, multi-functional brain tumor magnetic resonance imaging (MRI) tools into the clinic through the development of a brain-tumor imaging platform. 10/1/04 – 9/30/06
Analysis of rCBV Data Berlex Laboratories This funding supports the analysis and collection of rCBV data for purposes of designing a phase III clinical trial of a new contrast agent. 7/1/05 – 12/31/06