Jennifer Strande, MD, PhD
Division of Cardiovascular Medicine
Phone: (414) 955-7568
The work in Dr. Strande’s laboratory is directed at unraveling the molecular dysfunction involved in the pathogenesis of cardiomyopathies. She studies heart disease at varying levels of biological complexity including patients, animal models and individual heart cells to obtain insights into disease mechanisms. We are currently investigating the cellular and molecular mechanisms that cause cardiomyopathy in patients with muscular dystrophy.
Our group uses induced pluripotent stem cells (iPSCs) which are stem cells engineered from patient skin cells. These iPSCs retain the genetic background, including the specific dystrophin mutation of each patient. Dystrophin mutations containing iPSCs can be directed into cardiomyocytes to allow the investigation of abnormal events that are normally required to maintain cardiomyocyte health. The ultimate goal is to discover therapeutic approaches that can reverse the abnormalities caused by dystrophin-mutations and preserve a healthier cardiomyocyte and healthier heart.
Publications as listed in PubMed