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Nick Semenkovich, MD, PhD

Nick Semenkovich, MD, PhD

Assistant Professor

Locations

  • Hub for Collaborative Medicine, 6th Floor
    Clement J. Zablocki VA Medical Center, Endocrinology

Contact Information

General Interests

Rare Metabolic Disease

Education

Undergraduate, MIT, Computer Science & Biology
MD, Washington University
PhD, Genetics, Washington University
Internship & Residency, Brigham & Women’s Hospital
Fellowship, PSTP Scientist Track, Washington University

Biography

Dr. Nick Semenkovich is a physician-scientist with a joint appointment in the MCW Data Science Institute. He sees patients for the full range of endocrine and metabolic diseases. Outside of clinical practice, he researches liquid biopsies (including cell-free DNA) and their applications as biomarkers in a range of rare and understudied diseases.

Leadership Positions

MCW Internal

  • Founding Member, MCW Data Science Institute

Research Interests

Liquid biopsies, cell-free DNA, deep learning

Publications

  • Sensitive MRD Detection from Lymphatic Fluid after Surgery in HPV-Associated Oropharyngeal Cancer.

    (Earland N, Semenkovich NP, Ramirez RJ, Gerndt SP, Harris PK, Gu Z, Hearn AI, Inkman M, Szymanski JJ, Whitfield D, Wahle BM, Xu Z, Chen K, Alahi I, Ni G, Chen A, Winckler W, Zhang J, Chaudhuri AA, Zevallos JP.) Clin Cancer Res. 2024 Apr 01;30(7):1409-1421 PMID: 37939112 PMCID: PMC10982646 SCOPUS ID: 2-s2.0-85189772434 11/08/2023

  • DNA hypomethylation ameliorates erosive inflammatory arthritis by modulating interferon regulatory factor-8.

    (Swarnkar G, Semenkovich NP, Arra M, Mims DK, Naqvi SK, Peterson T, Mbalaviele G, Wu CL, Abu-Amer Y.) Proc Natl Acad Sci U S A. 2024 Feb 13;121(7):e2310264121 PMID: 38319963 PMCID: PMC10873594 SCOPUS ID: 2-s2.0-85184532962 02/06/2024

  • Pre-radiotherapy ctDNA liquid biopsy for risk stratification of oligometastatic non-small cell lung cancer.

    (Semenkovich NP, Badiyan SN, Samson PP, Stowe HB, Wang YE, Star R, Devarakonda S, Govindan R, Waqar SN, Robinson CG, Vlacich G, Pellini B, Chaudhuri AA.) NPJ Precis Oncol. 2023 Oct 02;7(1):100 PMID: 37783809 PMCID: PMC10545784 10/03/2023

  • Emerging Roles of Circulating Tumor DNA for Increased Precision and Personalization in Radiation Oncology.

    (Earland N, Chen K, Semenkovich NP, Chauhan PS, Zevallos JP, Chaudhuri AA.) Semin Radiat Oncol. 2023 Jul;33(3):262-278 PMID: 37331781 SCOPUS ID: 2-s2.0-85161992365 06/19/2023

  • Genomic approaches to cancer and minimal residual disease detection using circulating tumor DNA.

    (Semenkovich NP, Szymanski JJ, Earland N, Chauhan PS, Pellini B, Chaudhuri AA.) J Immunother Cancer. 2023 Jun;11(6) PMID: 37349125 PMCID: PMC10314661 SCOPUS ID: 2-s2.0-85162842966 06/23/2023

  • Identification of Racial Inequities in Access to Specialized Inpatient Heart Failure Care at an Academic Medical Center.

    (Eberly LA, Richterman A, Beckett AG, Wispelwey B, Marsh RH, Cleveland Manchanda EC, Chang CY, Glynn RJ, Brooks KC, Boxer R, Kakoza R, Goldsmith J, Loscalzo J, Morse M, Lewis EF, Abel S, Adams A, Anaya J, Andrews EH, Atkinson B, Avutu V, Bachorik A, Badri O, Bailey M, Baird K, Bakshi S, Balaban D, Barshop K, Baumrin E, Bayomy O, Beamesderfer J, Becker N, Berg DD, Berman AN, Blum SM, Boardman AP, Boden K, Bonacci RA, Brown S, Campbell K, Case S, Cetrone E, Charrow A, Chiang D, Clark D, Cohen AJ, Cooper A, Cordova T, Cuneo CN, de Feria AA, Deffenbacher K, DeFilippis EM, DeGregorio G, Deutsch AJ, Diephuis B, Divakaran S, Dorschner P, Downing N, Drescher C, D'Silva KM, Dunbar P, Duong D, Earp S, Eckhardt C, Elman SA, England R, Everett K, Fedotova N, Feingold-Link T, Ferreira M, Fisher H, Foo P, Foote M, Franco I, Gilliland T, Greb J, Greco K, Grewal S, Grin B, Growdon ME, Guercio B, Hahn CK, Hasselfeld B, Haydu EJ, Hermes Z, Hildick-Smith G, Holcomb Z, Holroyd K, Horton L, Huang G, Jablonski S, Jacobs D, Jain N, Japa S, Joseph R, Kalashnikova M, Kalwani N, Kang D, Karan A, Katz JT, Kellner D, Kidia K, Kim JH, Knowles SM, Kolbe L, Kore I, Koullias Y, Kuye I, Lang J, Lawlor M, Lechner MG, Lee K, Lee S, Lee Z, Limaye N, Lin-Beckford S, Lipsyc M, Little J, Loewenthal J, Logaraj R, Lopez DM, Loriaux D, Lu Y, Ma K, Marukian N, Matias W, Mayers JR, McConnell I, McLaughlin M, Meade C, Meador C, Mehta A, Messenger E, Michaelidis C, Mirsky J, Mitten E, Mueller A, Mullur J, Munir A, Murphy E, Nagami E, Natarajan A, Nsahlai M, Nze C, Okwara N, Olds P, Paez R, Pardo M, Patel S, Petersen A, Phelan L, Pimenta E, Pipilas D, Plovanich M, Pong D, Powers BW, Rao A, Ramirez Batlle H, Ramsis M, Reichardt A, Reiger S, Rengarajan M, Rico S, Rome BN, Rosales R, Rotenstein L, Roy A, Royston S, Rozansky H, Rudder M, Ryan CE, Salgado S, Sanchez P, Schulte J, Sekar A, Semenkovich N, Shannon E, Shaw N, Shorten AB, Shrauner W, Sinnenberg L, Smithy JW, Snyder G, Sreekrishnan A, Stabenau H, Stavrou E, Stergachis A, Stern R, Stone A, Tabrizi S, Tanyos S, Thomas C, Thun H, Torres-Lockhart K, Tran A, Treasure C, Tsai FD, Tsaur S, Tschirhart E, Tuwatananurak J, Venkateswaran RV, Vishnevetsky A, Wahl L, Wall A, Wallace F, Walsh E, Wang P, Ward HB, Warner LN, Weeks LD, Weiskopf K, Wengrod J, Williams JN, Winkler M, Wong JL, Worster D, Wright A, Wunsch C, Wynter JS, Yarbrough C, Yau WY, Yazdi D, Yeh J, Yialamas MA, Yozamp N, Zambrotta M, Zon R.) Circ Heart Fail. 2019 Nov;12(11):e006214 PMID: 31658831 PMCID: PMC7183732 10/30/2019

  • Impact of the gut microbiota on enhancer accessibility in gut intraepithelial lymphocytes.

    (Semenkovich NP, Planer JD, Ahern PP, Griffin NW, Lin CY, Gordon JI.) Proc Natl Acad Sci U S A. 2016 Dec 20;113(51):14805-14810 PMID: 27911843 PMCID: PMC5187723 SCOPUS ID: 2-s2.0-85006930186 12/03/2016

  • Effects of a gut pathobiont in a gnotobiotic mouse model of childhood undernutrition.

    (Wagner VE, Dey N, Guruge J, Hsiao A, Ahern PP, Semenkovich NP, Blanton LV, Cheng J, Griffin N, Stappenbeck TS, Ilkayeva O, Newgard CB, Petri W, Haque R, Ahmed T, Gordon JI.) Sci Transl Med. 2016 Nov 23;8(366):366ra164 PMID: 27881825 PMCID: PMC5152673 SCOPUS ID: 2-s2.0-84997787497 11/25/2016

  • Technical difficulties and evaluating e-health interventions.

    (Semenkovich NP.) JAMA Intern Med. 2014 Feb 01;174(2):304 PMID: 24493612 SCOPUS ID: 2-s2.0-84893622747 02/05/2014

  • Going viral: next-generation sequencing applied to phage populations in the human gut.

    (Reyes A, Semenkovich NP, Whiteson K, Rohwer F, Gordon JI.) Nat Rev Microbiol. 2012 Sep;10(9):607-17 PMID: 22864264 PMCID: PMC3596094 SCOPUS ID: 2-s2.0-84865169911 08/07/2012