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The Carroll Lab
Medical College of Wisconsin
Department of Ophthalmology, Eye Institute
925 N 87th St.
Milwaukee, WI 53226-4812
jcarroll@mcw.edu
(414) 456-2052
Dr. Carroll oversees the Comprehensive Color Vision Testing service at the Eye Institute. He is also the organizer of the Vision Science Distinguished Lecture Series. In addition, Dr. Carroll along with Dr. Kimberly Stepien and Dr. Judy Kim direct the Advanced Ocular Imaging Program at the Eye Institute.
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The Carroll Lab takes a multidisciplinary approach to the study of the human visual system. We are interested in developing a better understanding of retinal structure and function – both in the normal and diseased eye. The Carroll Lab also has broad interests in comparative color vision, foveal development, neuroscience, and behavioral aspects of human color vision (normal and aberrant).
One of the main focus areas of the lab is applying high-resolution retinal imaging tools to the study of the human retina. We have developed an adaptive optics fundus camera, and are currently working with Dr. Alfredo Dubra at the University of Rochester to develop an adaptive optics scanning laser ophthalmoscope. Normally, when taking a picture of the living retina the resolution (that is, the level of detail that can be visualized) is primarily limited by the poor optics of the eye. Adaptive optics imaging systems first measure and then compensate for these optical aberrations, and allow the visualization of individual cells in the retina (on the order of 2 microns in diameter). Such imaging could be used to identify individuals with cone dysfunction whose retinas might be more receptive to therapeutic intervention by virtue of having more intact photoreceptor cells or to track treatment response on a cellular level.
While adaptive optics provides high transverse resolution, optical coherence tomography (OCT) provides high axial resolution. The Carroll Lab currently has a number of spectral domain OCT (SD-OCT) systems for imaging the human retina (pediatric and adult) as well as animal models of retinal disease. We have invested significant resources in developing image analysis tools for SD-OCT with the aim of improving the clinical utility of this imaging modality.
We are also interested in assessing visual function, and are exploring intrinsic optical signals that can be uncovered with some of our high-resolution imaging tools. In addition, we are also interested in how variability at the level of the cone mosaic extends to the visual cortex. In collaboration with Dr. Daphne Bavelier at the University of Rochester and Dr. Ted DeYoe at the Medical College of Wisconsin, we are using adaptive optics to image the cone mosaic in individuals who have suffered from abnormal development of the cone mosaic and using fMRI to see how this impacts the retinotopic organization of the visual cortex.
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RECENT NEWS & INFO
The Department of Ophthalmology has established an advanced ocular imaging initiative at the Eye Institute-combining wisdom from multiple diciplines and keeping the mission of advancing vision and saving sight at the forefront of decision making. - More Info
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