Radiation Oncology

John E. Moulder, PhD Professor and Director of Radiation Biology Department of Radiation Oncology 8701 Watertown Plank Road Milwaukee, WI 53226 (414) 456-4670 jmoulder@mcw.edu

Curriculum Vitae

Research Interests

• The biological basis for carcinogenesis and cancer therapy
• Prevention and treatment of radiation-induced normal tissue injury
• The impact of tumor hypoxia on radiotherapy
• Biological aspects of human exposure to non-ionizing radiation
• Radiological terrorism countermeasures
• Radiobiological risks of space travel

Dr Moulder has published extensively in these areas, and his research has been supported by the National Institutes of Health and the American Cancer Society.

Dr Moulder has lectured on ionizing and non-ionizing radiation biology and human health to biologists, physicists, physicians, policy makers and industry groups around the world; and has served as a consultant and expert witness in several cases involving the alleged health effects of exposure to ionizing and non-ionizing radiation.

Dr Moulder is a member of the National Council on Radiation Protection, the Radiation Research Society, the Environmental Mutagen Society, the Bioelectromagnetics Society, and the IEEE. He is Senior Editor of Radiation Research and an Associate Editor of Experimental Biology and Medicine. He has served on a number of national and local advisory groups concerned with environmental health, non-ionizing radiation, uses of radiation in medicine, and radiological terrorism countermeasures.

Education

• PhD, Cell Biology, Yale University, New Haven, CT (1972).
• M Phil, Cell Biology, Yale University, New Haven, CT (1969).
• BA, Biology and Chemistry, Carleton College, Northfield, MN (1967).

Training

• Post-doctoral Fellowship Radiation Oncology, Yale University, New Haven, CT (1973-1975).

Representative Publications (last 5 years)

• Sieber F, Muir SA, Cohen EP, Fish BL, Mader M, Schock AM, Althouse BJ, Moulder JE. Dietary selenium for the mitigaction of radiation injury: Effects of selenium dose escalation and timing of supplementation. Radiat Res Jul 8 [Epub ahead of print], 2011.
• Baker JE, Moulder JE, Hopewell JW. Radiation as a risk factor for cardiovascular disease. Antioxid Redox Signal Mar 23 [Epub ahead of print], 2011.
• Mosvas B, Vikram B, Hauer-Jensen M, Moulder JE, Basch E, Brown SL,Kachnic LA, Dicker AP, Coleman CN, Okunieff P. Decreasing the adverse effects of cancer therapy: National Cancer Institute guidance for the clinical development of radiation injury mitigators. Clin Cancer Res 17(2):222-8, 2011.
• Martz MD, Moulder JE, Knight-Wiegert K. Hospital response during the Red Dragon drill.  Health Phys May:100 Suppl2:S56-9, 2011.
• Moulder JE, Cohen EP, Fish BL. Captopril and losartan for mitigation of renal injury caused by single dose total body irradiation. Radiat Res 175(1):29-36, 2011.
• William JP, Brown SL, Georges GE, Hauer-Jensen M, Hill RP, Huser AK, Kirsch DG, Macvittie TJ, Mason KA, Medhora MM, Moulder JE, Okunieff P, Otterson MF, Robbins ME, Smathers JB McBride WH. Animal models for medical countermeasures to radiation exposure. Radiat Res 173(4):557-78, 2011.
• Szabo S, Ghosh SN, Fish BL, Bodgia S, Tomic R, Kumar G, Morrow NV, Moulder JE, Jacobs ER, Medora M. Cellular inflammatory infiltrate in pneumonitis induced by a single moderate dose of thoracid x radiation in rats. Radiat Res 173(4): 545-56, 2010.
• Sharma M, Halligan BD, Wakim BT, Savin VJ, Cohen EP, Moulder JE. The urine proteome for radiation biodosimetry: Effect of total body vs. local kidney irradiation. Health Phys 98(2):186-95, 2010.
• Baker JE, Fish BL, Su J, Haworth ST, Strande JL, Komorowski RA, Migrino RQ, Doppalapudi A, Harmann L, Li XA, Hopewell JW, Moulder JE. 10 Gy total body irradiation increases risk of coronary scleroisi, degeneration of heart structure and function in a rat model. Int J Radiat Biol 85(12):1089-100, 2010.
• Ghosh SN, Zhang R, Fish BL, Semenenko VA, Li XA, Moulder JE, Jacobs ER, Medhora M. Renin-angiotensin system suppression mitigates experimental radiation pneumonitis. Int J Radiat Oncol Biol Phys 75(5):1528-36, 2009.
• Cohen EP, Pais P, Moulder JE. Chronic kidney disease after hematopoietic stem cell transplantation. Semin Nephrol 30(6):627-34, 2010.
• Cohen EP, Fish BL, Irving AA, Rajapurkar MM, Shah SV, Moulder JE.  Radiation Nephropathy is not mitigated by antagonists of oxidative stress.  Radiat Res 172:260-264, 2009. 
• Ghosh N, Wu Q, Mader M, Fish BL, Moulder JE, Jacobs ER, Medhora M, Molthen RC.  Vascular injury following whole thoracic X-ray irradiation in the rat.  Int J Rad Oncol Biol Phys, 74(1):192-199, 2009. 
• Sieber F, Muir SA, Cohen EP, North PE, Fish BL, Irving AA, Mader M, Moulder JE.  High-dose selenium for the mitigation of radiation injury: A pilot study of a rat model.  Radiat Res 171:368-373, 2009. 
• Lenarczyk M, Cohen EP, Fish BL, Irving AA, Sharma M, Driscoll CD, Moulder JE. Chronic oxidative stress as a mechanism for radiation nephropathy.  Radiat Res 171:164-172, 2009.   
• Sharma M. Halligan BD, Wakin BT, Savin VJ, Cohen EP, Moulder JE.  The urine proteome as a biomarker of radiation injury.  Proteomics Clin Applic 2:1065-1086, 2008. 
• Zhang R, Ghosh SN, Zhu D, North PE, Fish BL, Morrow NV, Lowry T, Nanchal R, Jacobs ER, Moulder JE, Medhora M. Structural and functional alteration in the rat lung following whole thoracic irradiation with moderate doses: Injury and recovery. Int J Rad Oncol Biol Phys, 84:487-497, 2008. 
• Cohen EP, Joines MM, Moulder JE.  Prevention and treatment of radiation injuries – The role of the renin-angiotensin system. In Late Effects on Normal Tissues of Cancer Treatment (P Rubin, LS Constine, LB Mark, P Okunieff, eds.), Springer-Verlag, Heidelberg, pp69-76, 2008.  
• Cohen EP, Irving AA, Drobyski WR, Kline JP, Passweg J, Talano JM, Juckett MB, Moulder JE.  Captopril to mitigate chronic renal failure after hematopoietic stem cell transplantation: a randomized controlled trial. Int J Rad Oncol Biol Phys, 70:1546-1551, 2008. 
• Moulder JE, Cohen EP.  Future strategies for mitigation and treatment of chronic radiation-induced normal tissue injury. Semin Rad Oncol 17(2):141-148, 2007.
• Moulder JE, Fish BL, Cohen EP.  Treatment of radiation nephropathy with ACE inhibitors and AII type-1 and type-2 receptor antagonists. Current Pharm Design 13:1317-1325, 2007.
• Molteni A, Wolfe LF , Ward WF, Ts’ao CH, Molteni LB, Veno P, Fish BL, Taylor JM, Quintalilla N, Moulder JE.  Effect of an angiotensin II receptor blocker and two angiotensin converting enzyme inhibitors on transforming growth factor-b (TGF‑b) and alpha smooth muscle actin (a-SMA). Current Pharm Design 13:1295-1298, 2007.
• Cohen EP, Fish BL, Sharma M, Li XA, Moulder JE.   The role of the angiotensin II type-2 (AT2) receptor in radiation nephropathy. Trans Res 150:106-115, 2007.
• Moulder JE, Cohen EP.  Renal dysfunction after total body irradiation: dose-effect relationship: In regard Kal and Van Kempen-Harteveld (Int J Radiat Oncol Biol Phys 2006;65:1228-1232). Int J Radiat Oncol Biol Phys 67:319, 2007.
• Cohen EP, Drobyski WR, Moulder JE.  Significant increase in end-stage renal disease after hematopoietic cell transplantation. Bone Marrow Transplant 39:571-572, 2007.