Quinn H. Hogan, MD
Professor of Anesthesiology
Director of Pain Research
Medical College of Wisconsin
8701 Watertown Plank Road
Milwaukee, WI 53226-0509
(414) 955-5727 | (414) 955-6507 (fax) | email@example.com
Dr. Hogan received his MD from Harvard Medical School in Boston, Massachusetts. He completed a Fellowship in Pain Management at the Medical College of Wisconsin and is Board Certified in Pain Management.
My laboratory focuses on identifying disrupted function of sensory neurons following injury and exploring novel therapies for pain. We employ combined physiological approaches of patch-clamp electrophysiology for identification of membrane biophysics, single unit recordings by sharp electrode in intact ganglia to evaluate neuronal function in the absence of dissociation, teased fiber recording, and microfluorometry to characterize the cytoplasmic Ca2+ signal that follows membrane activation. These approaches are ideally suited to explore the basic mechanisms of pain. My research has also emphasized the importance of valid behavioral testing as a necessary criterion for relevant pain study, as I am well aware from my clinical work of the potential for divergence between animal models and human disease. I as well as other scientists investigating pain mechanisms have come to recognize that there is a major shortfall in translation of these discoveries into therapies. Therefore, my research also explores and develops novel approaches for taking advantage of the extensive backlog of mechanistic discoveries, including targeting the sensory neuron for molecular manipulations, stem cell therapy, and electrical stimulation as treatment modalities.
My currently funded projects include the following. 1) “DRG engraftment of transduced mesenchymal stem cells to treat neuropathic pain” (NIH). This research examines and develops the use of genetically engineered mesenchymal stem cells as the source of analgesic peptide secretion after implantation in the DRG or subarachnoid space of rats in neuropathic pain models. 2) “AAV-encoded analgesic peptide aptamers for chronic pain” (VA Merit) This research examines the treatment of pain by small interfering peptides delivered to sensory neurons by AAV vectors. 3) “Cannabinoid Signaling in the dPAG: Specific Analgesic and Autonomic Functions” (VA Merit) This project explores the dorsal periaqueductal gray (dPAG) in the midbrain as a potential locus for pain control, and test the overall hypothesis that activation of the endocannabinoid system in the dPAG drives descending analgesic signaling that suppresses neuropathic pain. 4) “Persisting functional CNS changes following peripheral nerve repair” (VA SPiRE grant) This project will examine CNS changes in rats after peripheral nerve injury using fMRI, and will test the ability of peripheral nerve stimulation to prevent cortical reorganization after nerve injury and repair.