Widlansky Lab

Michael E. Widlansky, MD, MPH Michael E. Widlansky, MD, MPH

Associate Professor, Department of Medicine

Dr. Michael E. Widlansky's human vascular research laboratory has been formed to foster collaboration with investigators from other disciplines interested in the impact of vascular function on disease states relevant to their fields of interest.

Amberly Branum, MCW CVC Widlansky Lab Amberly Branum

Clinical Research Coordinator

My role in the Widlansky lab is to coordinate several research projects that explore endothelial dysfunction in individuals with Type 2 Diabetes and Coronary Artery Disease. This includes recruiting and consenting subjects, conducting study visits, and carrying out vascular tests. I preform a brachial artery ultrasound test known as Flow Mediated Dilation (FMD). The FMD provides the lab with valuable information into the pathology of endothelial dysfunction.

Jingli Wang, MD, PhD, MCW CVC Widlansky Lab Jingli Wang, MD, PhD

Research Scientist I

The interest of my study is related to vascular biology. The goal of my project is to reveal the pathophysiological relationship between derangements of endothelium-originated mitochondria and endothelial dysfunction in type 2 diabetes mellitus (T2DM) and insulin-induced hypoglycemia. Using basic laboratory techniques such as cell culture, video microscopy, fluorescence microscopy, confocal microscopy and tissue culture myograph, the biopsy specimens including arterioles and (mono-) lymphocytes from T2DM patients and non-T2DM patients are able to be extensively studied for understanding the pathogenesis of T2DM and hypoglycemia at the level of endothelium and mitochondria.

Rong Ying, MD, Research Technologist I Rong Ying, MD

Research Technologist I

My work in Dr. Widlansky's lab is to study endothelial function in human arterioles and in cultured human endothelial cells. Through performing these studies, the mechanisms of vascular endothelial dysfunction caused by T2DM and insulin-induced hypoglycemia are being explored at the cellular and molecular levels. As a research technologist, I also help to maintain a human endothelial cell line for all investigators in the lab and to train students who are interested in vessel dissection and in vitro vessel study.

Mike Tanner, MCW CVC Widlansky Lab Mike Tanner

Graduate Student

My research focuses on endothelial dysfunction induced via hypoglycemia experienced by people with Type II Diabetes. I utilize a variety of techniques and approaches in an effort to understand the mechanism through which hypoglycemia effects the endothelium. Currently, I am investigating the role mitochondrial morphology and function have during hypoglycemic conditions and am working to identify proteins and regulatory events responsible for mitochondrial fragmentation. Our lab routinely uses human microvessels to study vasoactivity ex vivo as well as human endothelial cells for in vitro work, while applying an array of pharmacologic and molecular perturbations to elucidate the causes of endothelial dysfunction in our disease model.

Mobin Malik, MD, MCW CVC Widlansky Lab Mobin Malik, MD

Research Fellow

My research is focused on understanding the biological processes that contribute to the endothelial dysregulation and concentrates on the interface between experimental basic science and clinical medicine. In the Widlansky lab, by using diabetic mouse model, we hope to elucidate the role of novel Mir29 in the development of endothelial dysfunction. In addition, I am currently involved in a randomized clinical trial to determine whether dipeptidyl peptidase-4 (DPP-4) inhibitors improve endothelial function in type 2 diabetics. Improvement of endothelial function is a desirable therapeutical goal with potential of significant clinical impact in improving cardiovascular outcomes in various disease states; hopefully, our research will bring us a step closer to achieving it.

Tisa Suboc, MD, MCW CVC Widlansky Lab Tisha Suboc, MD

Research Fellow

The vascular endothelium is our laboratory’s main focus. Dysfunction within the endothelium has been linked to the development of atherosclerosis and increased risk of cardiovascular events. Projects that I am involved in studies the mechanism of endothelial dysfunction related to the development of hypoglycemia. In addition, we are also evaluating the role of derangements in the mitochondrial homeostasis leading to development of endothelial dysfunction in humans with longstanding type 2 diabetes. We study microvascular functions in humans by obtaining microvessels in subcutaneous fat via biopsies of subcutaneous adipose. Another project that I am also involved in focuses on sedentary older adults and the effects of physical activity on the vascular endothelium. We study the vascular endothelium in these subjects using brachial artery flow mediated dilation (FMD). One of our newer studies is collaboration with Dr. Baker’s lab, which evaluates the effects of probiotic supplementation on the vascular endothelial in human males with history of coronary artery disease.

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