Center for AIDS Intervention Research
Dr. Andrew Petroll is a clinical Infectious Disease Specialist and a faculty researcher at the Center for AIDS Intervention Research (CAIR). CAIR is a multidisciplinary HIV prevention research center that is supported by an AIDS research grant from the National Institute of Mental Health. CAIR also receives grant support from other sources, including the Centers for Disease Control and Prevention, the Wisconsin AIDS/HIV Program, and the Medical College of Wisconsin. The research center is based in the Department of Psychiatry and Behavioral Medicine of the Medical College of Wisconsin. The research mission of the CAIR is to develop, conduct, and evaluate new interventions to prevent HIV among persons most vulnerable to the disease.
Dr. Petroll's research interests include how patients' risk behaviors for HIV transmission are addressed in clinical settings, how patient-physician interactions affect the disclosure and discussion of HIV risk behaviors, and how patient and physician characteristics influence such discussions. He is interested in studying the effectiveness of interventions aimed at improving HIV risk behavior discussions between health care providers and both HIV-negative and HIV-positive patients, assessing HIV testing behaviors within high-risk populations, and intervening to increase HIV testing. He is currently conducting a study that is evaluating medical providers' attitudes and experience with prescribing HIV pre-exposure prophylaxis (PrEP) to patients at risk for acquiring HIV. Recent Publications
The Coburn Lab is interested in how the pathogenic spirochetes Borrelia burgdorferi and Leptospira interrogans interact with mammalian cell surface receptors to facilitate establishment of disseminated infection. We use approaches from Biochemistry, Molecular Biology, Cell Biology, and classical Microbiology to identify specific host cell receptors, the bacterial proteins that bind those receptors, and to understand the consequences of those interactions. Work in the Coburn Lab is funded by 4 grants from the NIH. For more information and published lists, go to Coburn Lab.
Ixodes scapularis nymph, photograph taken by Dorothee Grimm, PhD
Borrelia burgdorferi attached to a human platelet, photograph from Coburn et al, (1993) PNAS 90: 7059-7063
Leptospira interrogans attached to human epithelial cell, photograph taken by Denise Martinez
Dr. Kron presently serves as the principal investigator on an NIH-NIAID funded collaborative study to identify actinomycete-derived natural compounds that might be useful in treating human filiarial diseases, which infect millions of persons in tropical regions of the world. This research includes cooperation among an international network of laboratories, including MCW, Michigan State University Department of Biochemistry and Molecular Biology, European Molecular Biology Laboratory-Grenoble in France, Goeteborg University and Umea University in Sweden, and the University of the Philippines. The researchers are working to identify novel chemical scaffolds that inhibit recombinant parasite aminoacyl-tRNA synthetase (AARS). Dr. Kron had led a group focused on the natural products and biodiversity issues of terrestrial and marine organisms in the Philippines, which, with 7,100 islands, is considered one of five biodiversity hotpots worldwide. Dr. Kron has a broad array of international health work in his career, including as a consultant to the NIH-MSU-Sudan Medical Parasitology Program in Khartoum, fellow in the Division of Infectious Diseases and Geographic Medicine at Case Western Reserve University, a member of the core faculty for the MSU Genetics Program Center for Latin American and Caribbean Studies, and as a visiting scientist for the NIH-Philippines Tropical Medicine Research Center in Manila. Dr. Kron has served as an advisor to the World Health Organization Special Program in Tropical Diseases, and has been a member of three National Institute of Allergy and Infectious Diseases study sections on infectious diseases. He holds five MSU-U.S. patents related to assay development and anti-parasite drug discovery. In 2013-2014 Dr. Kron was appointed as a Senior Science Advisor to the US Department of State, Bureau of East Asian and Pacific Affairs, and supported USG activities related to the 2014 International AIDS Conference in Melbourne, Australia. For more information please visit the Kron Lab page. Recent Publications
As an academic institution, the Froedtert Hospital Infectious Disease clinic is able to offer opportunities to participate in a variety of clinical trials. MCW faculty are engaged in a variety of clinical research trials conducted in collaboration with research networks and industry sponsored-trials. Faculty also practice at the AIDS Resource Center of Wisconsin and are able to offer most of the clinical trials through that location as well.
INSIGHT | PI: Michael Frank, MD
The Medical College of Wisconsin's Division of Infectious Diseases has been an affiliate site for the International Network for Strategic Initiatives in Global HIV Trials (INSIGHT) as an enrolling site for the SMART trial (Strategies for the Management of Anti-Retroviral Therapy) which investigated whether it was better to treat patients with HIV continuously with antiretrovirals or to treat them episodically based on immune function.
In 2010, the START trial (Strategic Timing of Anti-Retroviral Treatment) began in order to determine the optimal timing of initiation of antiretroviral therapy (ART) with regard to morbidity and mortality among HIV-1 infected patients who are naïve to ART and have CD4 + cell counts greater than 500 cells/mm3. The START study has enrolled over 4,600 participants worldwide. This study randomizes participants into two study arms:
- Immediate initiation of ART
- Deferred ART until the participant’s CD4+ cell count decreases to less than 350 cells/mm3
Enrollment began in April 2009 and ended on December 23rd, 2013 with 4,688 participants. In May 2015, enough data was collected to determine the optimal time to initiate antiretroviral therapy. Previous guidelines recommended earlier initiation of ART, but no randomized-control trials had been done to address this important question prior to the START study.
INSIGHT is one of six HIV/AIDS clinical trial networks funded in 2006 by the National Institute of Allergy and Infectious Diseases, a component of the National Institutes of Health. INSIGHT's mission is to define optimal strategies for the management of HIV and other infectious diseases through a global clinical research network. INSIGHT conducts studies worldwide.
REPRIEVE Study | PI: Michael Frank, MD
In 2015, enrollment in a random trial to prevent cardiovascular disease (CVD) in people with HIV began at MCW’s division of Infectious Diseases. People living with HIV are 50-100% more likely to develop CVD than people who do not have HIV.
MCW is working with the AIDS Clinical Trials Group (ACTG) and National Institute of Allergy and Infectious Diseases (NIAID) on this trial. Pitavastatin is FDA approved to lower cholesterol along with diet and exercise. The REPRIEVE trial tests whether Pitavastatin can prevent heart disease in people living with HIV.
Up to 6,500 people between the ages of 40 and 75, who have been on ART for at least six months, and who have no history of heart disease will enroll in this study. Participants are expected to make three visits per year for four years. The study is expected to run for 72 months (6 years).
Please visit the REPRIEVE Trial website for more information.
Industry Sponsored Trials
A number of faculty serve as Principal Investigators for industry-sponsored trials. These trials are often done to determine if drugs are safe and effective. Ongoing trials involve the following investigational agents:
- Stribild for HIV | PI: Andrew Petroll, MD
- STR Containing Tenofovir Alafenamide | PI: Andrew Petroll, MD
For more information about any of our HIV clinical trials, please contact Sonija Parker, Research Coordinator, at (414) 805-0708 or at firstname.lastname@example.org or Nancy Grey, Research Assistant, at (414) 805-0747 or at email@example.com.