Resuscitation Research Center at Medical College of Wisconsin
The Resuscitation Research Center (RRC) in the Department of Emergency Medicine department at the Medical College of Wisconsin is supported by federal funding to collaborate with researchers, clinicians and EMS at the local and national level on observational and interventional clinical trials in the areas of emergency resuscitation and neurological emergency research. The RRC has dedicated infrastructure to coordinate clinical trial activities 24/7.
The Resuscitation Research Center is also a regional site for two NIH funded research networks: the Resuscitation Outcomes Consortium and the Neurological Emergencies Treatment Trials Network.
Resuscitation Outcomes Consortium (ROC)
What is ROC?
ROC is a clinical trial network focusing on research in the area of pre-hospital cardiopulmonary arrest and severe traumatic injury.
The mission of the Resuscitation Outcomes Consortium (ROC) is to provide infrastructure and project support for clinical trials and other outcome-oriented research in the areas of cardiopulmonary arrest and sever traumatic injury that will rapidly lead to evidence-based change in clinical practices.
ROC consists of 10 Regional Clinical Centers (RCCs) and a Data and Coordinating Center (DCC) that will provide the necessary infrastructure to conduct multiple collaborative trials to aid rapid translation of promising scientific and clinical advances to improve resuscitation outcomes. Trials may evaluate existing or new therapies (such as pharmacologic immune modulators) as well as clinical management strategies (such as new resuscitative fluids, novel hemorrhage control strategies, the use of cerebral protection and neurologic preservation, metabolically directed therapies, and alternative methods of delivering CPR or defibrillation).
Current ROC Clinical Trials at MCW:
Public Notification and Community Consultation for Amiodarone (PM101), Lidocaine or Neither for Out-Of-Hospital Cardiac Arrest Due to Ventricular Fibrillation or Tachycardia. Department of Emergency Medicine, Medical College of Wisconsin.
Public Notification and Community Consultation for Trial of Continuous Compressions versus Standard CPR in Patients with Out-Of-Hospital Cardiac Arrest.
Data collection about out-of-hospital cardiac arrest including the capacity to differentiate between cases treated by EMS and cases that are not treatable.
To determine if use of Pre-hospital Tranexamic Acid for traumatic brain injury (TBI) will evaluate whether TXA initiated in the pre-hospital setting is beneficial for patients with moderate to severe TBI.
Neurological Emergencies Treatment Trials Network (NETT)
What is NETT?
The NIH has created a Neurological Emergencies Treatment Trials (NETT) Network to conduct large simple trials to reduce the burden of very acute injuries and illnesses affecting the brain, spinal cord, and peripheral nervous system. The network recognizes and seeks to explore the special narrow window of opportunity that seems to exist in treating neurologic damage from a variety of pathologies ranging from stroke to traumatic brain injury to seizures to meningitis. The study of very rapid interventions will have to be implemented by paramedics in the field, or by physicians in the Emergency Department. This network provides the basis for conducting efficient studies in these environments.
The mission of the Neurological Emergencies Treatment Trials (NETT) Network is to improve outcomes of patients with acute neurologic problems through innovative research focused on the emergent phase of patient care.
Current NETT Clinical Trials at MCW:
Stroke Hyperglycemia Insulin Network Effort (SHINE) Trial.
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Resuscitation Research Center Information:
The Resuscitation Research Center can be contacted by phone or email.
If you do not wish to participate in this study, an opt-out bracelet is available for your use. Simply wear the opt-out bracelet. Healthcare providers will not enter you in the study.
The IRB responsible for the review, approval, and continuing review of the clinical investigation may approve that investigation without requiring that informed consent of all research subjects be obtained if the IRB finds that additional requirements and protections for research patients have been met.
Public notices of currently active trials that meet the FDA guidelines for exception from informed consent under emergency circumstances.