Pharmacology and Toxicology

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John D. Imig, PhD

 

 

Professor
Department of Pharmacology
and Toxicology

Can a research laboratory make major breakthroughs and develop novel therapeutics for cardiovascular and kidney diseases? The answer is a resounding, YES!

Dr. Imig’s research has focused on a class of fatty acids, arachidonic acid metabolites that have been targeted by drugs for the treatment of pain, fever, blood clotting, and asthma. Utilizing animal models of cardiovascular and kidney diseases his laboratory has demonstrated that arachidonic acid metabolites called epoxyeicosatrienoic acids (EETs) and the enzyme soluble epoxide hydrolase are not properly regulated during disease states. Over the past decade his laboratory was a major driving force in the development of drugs that inhibit the soluble epoxide hydrolase enzyme and one of these drugs is currently being tested in humans for the treatment of chronic obstructive pulmonary disease (COPD). More recently, the laboratory has focused on developing EET-based drugs for the treatment of hypertension, acute renal failure, and chronic kidney disease. These novel small molecule EET analogs are demonstrating great potential and could one day in the near future be used to treat cardiovascular and kidney diseases in humans.

     


 



Pharmacology & Toxicology Headlines

9/24/14 . . .  Dr. Carol Williams Ridin' to a Cure.

9/17/14 . . .  Dr. Cecilia Hillard, treating post traumatic stress disorder.

6/30/2014 . . . Qing-Song Liu, PhD is exploring new methods to fight drug addiction with a new 5 year, 1.6 million NIH grant.

6/24/2014 . . . Cecilia Hillard's, PhD new grant  Drug Addiction: What Causes Relapse?

3/13/2014 . . . Rock River Cancer Research Foundation awards $75,000 to Dr. Carol Williams, PhD.

2/25/2014 . . . Founding Director of the Neuroscience Research Center, Dr. Cecilia Hillard, announces gift for neuroscience research from BMO Harris Bank.

2/4/2014 . . .  Abdul Hye Khan, was selected as a winner of the 2014 APS Renal Section Research Recognition Award.

1/16/2014 . . . 2013 American Heart Walk Association congratulates Pharmacology for being the top fundraising team.

12/2013 . . . Graduate Student Alicia Thomas Barr and her mentor Dr. Alan Bloom are using the fMRI to pursue new discoveries for cancer patients.

10/24/13 . . . Geneva Wahl, Medical Student Summer Research Program in Dr. John Imig's Lab, was one of twelve medical students honored during Research Day Poster Session.

10/10/13 . . . Graduate Student Patrick Gonyo was one of the winners of the 23rd Annual Graduate School of Biomedical Sciences Research Poster Session

10/15/13 . . . Dr. Carol Williams along with others don their leathers to raise money for cancer research

Archive Pharmacology Headlines

 

Earn a graduate degree from the Department of Pharmacology and Toxicology

Our graduate degree program includes dynamically changing disciplines such as neuropharmacology and molecular pharmacology. This program receives many students from the Interdisciplinary Program of Neuroscience and Biomedical Science.

 

 

Contact Information:

Pharmacology and Toxicology

Medical College of Wisconsin
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Page Updated 09/29/2014