Pharmacology and Toxicology

Welcome to the Department of Pharmacology and Toxicology at the Medical College of Wisconsin is dedicated to quality in research, graduate and postdoctoral training and medical education. The research interests of our faculty are broadly based in cardiovascular pharmacology, neuropharmacology, cancer pharmacology, toxicology and molecular pharmacology. The research programs in the Department of Pharmacology and Toxicology are also multidisciplinary in nature and have strong associations with researchers of other basic science and clinical departments. Read more...

John D. Imig, PhD

John D. Imig, PhD

Professor, Pharmacology and Toxicology

Can a research laboratory make major breakthroughs and develop novel therapeutics for cardiovascular and kidney diseases? The answer is a resounding, YES!

Dr. Imig’s research has focused on a class of fatty acids, arachidonic acid metabolites that have been targeted by drugs for the treatment of pain, fever, blood clotting, and asthma. Utilizing animal models of cardiovascular and kidney diseases his laboratory has demonstrated that arachidonic acid metabolites called epoxyeicosatrienoic acids (EETs) and the enzyme soluble epoxide hydrolase are not properly regulated during disease states. Over the past decade his laboratory was a major driving force in the development of drugs that inhibit the soluble epoxide hydrolase enzyme and one of these drugs is currently being tested in humans for the treatment of chronic obstructive pulmonary disease (COPD). More recently, the laboratory has focused on developing EET-based drugs for the treatment of hypertension, acute renal failure, and chronic kidney disease. These novel small molecule EET analogs are demonstrating great potential and could one day in the near future be used to treat cardiovascular and kidney diseases in humans.

Earn a graduate degree from Pharmacology and Toxicology

Our graduate degree program includes dynamically changing disciplines such as neuropharmacology and molecular pharmacology. This program receives many students from the Interdisciplinary Program of Neuroscience and Biomedical Science.

Contact Pharmacology and Toxicology for more information

Pharmacology & Toxicology Headlines

4/26/15: Chris Olsen, PhD, discussed concussions and substance abuse on Radio 620 WTMJ Weekend Morning News.

11/17/14: Terri deRoon-Cassini, PhD and Cecilia Hillard, PhD, investigate biological factors of post-traumatic stress disorder.

9/24/14: Carol Williams, PhD Ridin' to a Cure.

9/17/14: Cecilia Hillard, PhD, treating post traumatic stress disorder.

6/30/2014: Qing-Song Liu, PhD is exploring new methods to fight drug addiction with a new 5 year, 1.6 million NIH grant.

6/24/2014: Cecilia Hillard's, PhD new grant Drug Addiction: What Causes Relapse?

3/13/2014: Rock River Cancer Research Foundation awards $75,000 to Carol Williams, PhD.

2/25/2014: Founding Director of the Neuroscience Research Center, Cecilia Hillard, PhD, announces gift for neuroscience research from BMO Harris Bank.

2/4/2014: Abdul Hye Khan, was selected as a winner of the 2014 APS Renal Section Research Recognition Award.

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Other Pharmacology and Toxicology News

Dr. Williams Receives $1.75 NCI Grant to Repurpose Medications to Fight Breast Cancer

May 6 - Carol Williams, PhD, (Pharmacology & Toxicology) received a five-year, $1.75 million grant from the National Cancer Institute to study a new approach at limiting the spread of breast cancer. Dr. Williams will repurpose existing medications that target a family of molecules suspected in the spread of breast cancer. The medications are not currently used to treat cancers. Health Canal

A new use for older drugs to target the spread of breast cancer

Apr. 30 - The Medical College of Wisconsin (MCW) has received a five-year, $1.75 million grant from the National Institutes of Health’s National Cancer Institute to study a new approach at limiting the spread of breast cancer.

Researchers Awarded NIH Grant to Study Link between Brain Injury and Substance Abuse

Apr. 28 - Christopher Olsen, PhD, (Pharmacology & Toxicology) and Matthew Budde, PhD, (Neurosurgery) are co-investigators of a two-year, $420,000 grant from the National Institute on Drug Abuse to study the link between traumatic brain injury and substance abuse disorder. Waukesha Now

Investigators to study link between brain injury and addiction

Apr. 16 - The Medical College of Wisconsin (MCW) has received a two-year, $420,000 grant from the National Institutes of Health’s National Institute on Drug Abuse to research the link between traumatic brain injury (TBI) and substance abuse disorder.

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Pharmacology and Toxicology
Medical College of Wisconsin
8701 Watertown Plank Road
Milwaukee, WI 53226-0509

(414) 955-8267 | Fax: (414) 955-6545

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Medical College of Wisconsin
8701 Watertown Plank Road
Milwaukee, WI 53226
(414) 955-8296
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Page Updated 04/29/2015
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