Pharmacology and Toxicology

Welcome to the Department of Pharmacology and Toxicology at the Medical College of Wisconsin is dedicated to quality in research, graduate and postdoctoral training and medical education. The research interests of our faculty are broadly based in cardiovascular pharmacology, neuropharmacology, cancer pharmacology, toxicology and molecular pharmacology. The research programs in the Department of Pharmacology and Toxicology are also multidisciplinary in nature and have strong associations with researchers of other basic science and clinical departments. Read more...

John D. Imig, PhD

John D. Imig, PhD

Professor, Pharmacology and Toxicology

Can a research laboratory make major breakthroughs and develop novel therapeutics for cardiovascular and kidney diseases? The answer is a resounding, YES!

Dr. Imig’s research has focused on a class of fatty acids, arachidonic acid metabolites that have been targeted by drugs for the treatment of pain, fever, blood clotting, and asthma. Utilizing animal models of cardiovascular and kidney diseases his laboratory has demonstrated that arachidonic acid metabolites called epoxyeicosatrienoic acids (EETs) and the enzyme soluble epoxide hydrolase are not properly regulated during disease states. Over the past decade his laboratory was a major driving force in the development of drugs that inhibit the soluble epoxide hydrolase enzyme and one of these drugs is currently being tested in humans for the treatment of chronic obstructive pulmonary disease (COPD). More recently, the laboratory has focused on developing EET-based drugs for the treatment of hypertension, acute renal failure, and chronic kidney disease. These novel small molecule EET analogs are demonstrating great potential and could one day in the near future be used to treat cardiovascular and kidney diseases in humans.

Earn a graduate degree from Pharmacology and Toxicology

Our graduate degree program includes dynamically changing disciplines such as neuropharmacology and molecular pharmacology. This program receives many students from the Interdisciplinary Program of Neuroscience and Biomedical Science.

Contact Pharmacology and Toxicology for more information

Pharmacology & Toxicology Headlines

9/25/15: CB2 transgenic mouse model developed by the Cecilia Hillard, PhD Lab.

7/9/15: Chris Olsen, PhD and Scott Levick, PhD named recipients of inaugural Presidential Faculty Scholar Awards.

4/26/15: Chris Olsen, PhD, discussed concussions and substance abuse on Radio 620 WTMJ Weekend Morning News.

11/17/14: Terri deRoon-Cassini, PhD and Cecilia Hillard, PhD, investigate biological factors of post-traumatic stress disorder.

9/24/14: Carol Williams, PhD Ridin' to a Cure.

9/17/14: Cecilia Hillard, PhD, treating post traumatic stress disorder.

Archived Pharmacology Headlines

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Other Pharmacology and Toxicology News

Dr. Kathryn Gauthier, faculty member in pharmacology and toxicology, dies at age 60

July 16 - Kathryn M. “Kathy” Gauthier, PhD, associate professor of pharmacology and toxicology, died Monday, July 13. She was 60 years old.

Dr. Imig Comments on Identification of Key Mechanism in Neuropathic Pain

July 14 - John Imig, PhD provides expert comment on the identification of a key mechanism in neuropathic pain by scientists at the University of California, Davis. The discovery could eventually benefit millions of patients with chronic pain from trauma, diabetes, shingles, multiple sclerosis or other conditions that cause nerve damage. UC-Davis

Dr. Imig Expects Companies to Invest in Drugs Targeted to Gene Mutations

July 13 - John Imig, PhD, (Pharmacology & Toxicology) tells International Business Times that he expects the debut of the PCSK-9 inhibitors (which targets a mutation in the PCSK-9 gene, which causes high cholesterol) will spur companies to invest in this area as scientists continue their search for genetic factors underlying major diseases. International Business Times

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Pharmacology and Toxicology
Medical College of Wisconsin
8701 Watertown Plank Road
Milwaukee, WI 53226-0509

(414) 955-8267 | Fax: (414) 955-6545

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8701 Watertown Plank Road
Milwaukee, WI 53226
(414) 955-8296
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Page Updated 09/25/2015