Freed, Julie, MD, PhD | Medical College of Wisconsin

Julie Freed, MD, PhD

Assistant Professor

Contact Information

jfreed@mcw.edu

Education

BA, Physiology, University of Minnesota, 2002
PhD, Physiology, Medical College of Wisconsin, 2008
MD, Medical College of Wisconsin, 2011
Residency, Anesthesiology, Medical College of Wisconsin, 2016
Fellowship, Cardiac Anesthesiology, Medical College of Wisconsin, 2017

Research Interests

Human coronary microvascular dysfunction
The role of sphingolipids in vascular function
Mechanisms and treatments of vasoplegia
Surgical prehabilitation in frail patients

Dr. Freed’s research primarily focuses on the role that sphingolipids have in the development of endothelial dysfunction in the human microcirculation. Elevated plasma levels of ceramide, a prototypical sphingolipid, is now considered an independent risk factor for major adverse cardiovascular events in otherwise healthy people. The Freed lab is currently investigating how these bioactive lipids are regulated in human endothelial cells.

As a cardiac anesthesiologist, Dr. Freed is also interested in intraoperative blood pressure control including mechanisms and treatments of vasoplegia. Other interests include translating her work in the lab to improve outcomes for surgical patients.

High-Dose Vitamin B12 in Vasodilatory Shock: A Narrative Review.

(Patel JJ, Venegas-Borsellino C, Willoughby R, Freed JK.) Nutr Clin Pract. 2019 Aug;34(4):514-520.
Gender Composition and Trends of Journal of Cardiothoracic and Vascular Anesthesia Editorial Board Membership: A 33-Year Analysis, 1987-2019.

(Pagel PS, Freed JK, Lien CA.) J Cardiothorac Vasc Anesth. 2019 Jul 25.
Gender Differences in Authorship in the Journal of Cardiothoracic and Vascular Anesthesia: A 28-Year Analysis of Publications Originating From the United States, 1990-2017.

(Pagel PS, Freed JK, Lien CA.) J Cardiothorac Vasc Anesth. 2019 03;33(3):593-599.
Healing the Broken Heart With Adrenomedullin.

(Freed JK.) Circ Res. 2019 01 04;124(1):15-17.
A 50-year analysis of gender differences in United States authorship of original research articles in two major anesthesiology journals

(Pagel PS, Freed JK, Lien CA.) Scientometrics. 2019.
There is no way to sugar coat it, you are getting older.

(Freed JK, Durand MJ.) Am J Physiol Heart Circ Physiol. 2018 09 01;315(3):H632-H633.
Advanced Age Attenuates Left Ventricular Filling Efficiency Quantified Using Vortex Formation Time: A Study of Octogenarians With Normal Left Ventricular Systolic Function Undergoing Coronary Artery Surgery.

(Pagel PS, Dye L 3rd, Boettcher BT, Freed JK.) J Cardiothorac Vasc Anesth. 2018 08;32(4):1775-1779.
A Rare Cause of Intermittent Dyspnea, Occasional Palpitations, and Atypical Chest Discomfort.

(Dye L 3rd, Freed JK, Leschke JR, Pagel PS.) J Cardiothorac Vasc Anesth. 2018 08;32(4):2031-2033.
An Unusual Cause of an Isolated Transient Ischemic Attack in an Otherwise Healthy Elderly Man.

(Freed JK, Simon JA, Iqbal Z, Almassi GH, Pagel PS.) J Cardiothorac Vasc Anesth. 2018 06;32(3):1529-1532.
Hydroxocobalamin With or Without Methylene Blue May Improve Fluid Balance in Critically Ill Patients With Vasoplegic Syndrome After Cardiac Surgery: A Report of Two Cases.

(Zundel MT, Feih JT, Rinka JRG, Boettcher BT, Freed JK, Kaiser M, Ghadiali HY, Tawil JN, Woehlck HJ, Pagel PS.) J Cardiothorac Vasc Anesth. 2018 02;32(1):452-457.
Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery.

(Pagel PS, Dye L 3rd, Hill GED, Vega JL, Tawil JN, De Vry DJ, Chandrashekarappa K, Iqbal Z, Boettcher BT, Freed JK.) J Vis Exp. 2018 11 28(141).
Cardiac Physiology

(Pagel PS, Freed JK.) Kaplan's Essentials of Cardiac Anesthesia for Cardiac Surgery. 6 December 2017:62-79.

Lab Members

Laura Norwood PhD, Research Scientist
Mary Schulz, Research Technician
Kelsey Walters, Medical Student

Julie Freed