Julie Freed, MD, PhD
Assistant Professor
Contact Information
Education
PhD, Physiology, Medical College of Wisconsin, 2008
MD, Medical College of Wisconsin, 2011
Residency, Anesthesiology, Medical College of Wisconsin, 2016
Fellowship, Cardiac Anesthesiology, Medical College of Wisconsin, 2017
Research Interests
- Human coronary microvascular dysfunction
- The role of sphingolipids in vascular function
- Mechanisms and treatments of vasoplegia
- Surgical prehabilitation in frail patients
Dr. Freed’s research primarily focuses on the role that sphingolipids have in the development of endothelial dysfunction in the human microcirculation. Elevated plasma levels of ceramide, a prototypical sphingolipid, is now considered an independent risk factor for major adverse cardiovascular events in otherwise healthy people. The Freed lab is currently investigating how these bioactive lipids are regulated in human endothelial cells.
As a cardiac anesthesiologist, Dr. Freed is also interested in intraoperative blood pressure control including mechanisms and treatments of vasoplegia. Other interests include translating her work in the lab to improve outcomes for surgical patients.
Publications
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(Pagel PS, Freed JK, Lien CA.) J Cardiothorac Vasc Anesth. 2019 Dec;33(12):3229-3234.
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High-Dose Vitamin B12 in Vasodilatory Shock: A Narrative Review.
(Patel JJ, Venegas-Borsellino C, Willoughby R, Freed JK.) Nutr Clin Pract. 2019 Aug;34(4):514-520.
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(Pagel PS, Freed JK, Lien CA.) J Cardiothorac Vasc Anesth. 2019 03;33(3):593-599.
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Healing the Broken Heart With Adrenomedullin.
(Freed JK.) Circ Res. 2019 01 04;124(1):15-17.
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(Pagel PS, Freed JK, Lien CA.) Scientometrics. 2019.
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There is no way to sugar coat it, you are getting older.
(Freed JK, Durand MJ.) Am J Physiol Heart Circ Physiol. 2018 09 01;315(3):H632-H633.
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(Pagel PS, Dye L 3rd, Boettcher BT, Freed JK.) J Cardiothorac Vasc Anesth. 2018 08;32(4):1775-1779.
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A Rare Cause of Intermittent Dyspnea, Occasional Palpitations, and Atypical Chest Discomfort.
(Dye L 3rd, Freed JK, Leschke JR, Pagel PS.) J Cardiothorac Vasc Anesth. 2018 08;32(4):2031-2033.
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An Unusual Cause of an Isolated Transient Ischemic Attack in an Otherwise Healthy Elderly Man.
(Freed JK, Simon JA, Iqbal Z, Almassi GH, Pagel PS.) J Cardiothorac Vasc Anesth. 2018 06;32(3):1529-1532.
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(Zundel MT, Feih JT, Rinka JRG, Boettcher BT, Freed JK, Kaiser M, Ghadiali HY, Tawil JN, Woehlck HJ, Pagel PS.) J Cardiothorac Vasc Anesth. 2018 02;32(1):452-457.
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(Pagel PS, Dye L 3rd, Hill GED, Vega JL, Tawil JN, De Vry DJ, Chandrashekarappa K, Iqbal Z, Boettcher BT, Freed JK.) J Vis Exp. 2018 11 28(141).
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(Pagel PS, Freed JK.) Kaplan's Essentials of Cardiac Anesthesia for Cardiac Surgery. 6 December 2017:62-79.
Lab Members
- Laura Norwood PhD, Research Scientist
- Mary Schulz, Research Technician
- Kelsey Walters, Medical Student