Freed, Julie, MD, PhD | Medical College of Wisconsin

Julie Freed, MD, PhD

Assistant Professor

Contact Information

jfreed@mcw.edu

Biography

Education

BA, Physiology, University of Minnesota, 2002
PhD, Physiology, Medical College of Wisconsin, 2008
MD, Medical College of Wisconsin, 2011
Residency, Anesthesiology, Medical College of Wisconsin, 2016
Fellowship, Cardiac Anesthesiology, Medical College of Wisconsin, 2017

Research Interests

Human coronary microvascular dysfunction
The role of sphingolipids in vascular function
Mechanisms and treatments of vasoplegia
Surgical prehabilitation in frail patients

Dr. Freed’s research primarily focuses on the role that sphingolipids have in the development of endothelial dysfunction in the human microcirculation. Elevated plasma levels of ceramide, a prototypical sphingolipid, is now considered an independent risk factor for major adverse cardiovascular events in otherwise healthy people. The Freed lab is currently investigating how these bioactive lipids are regulated in human endothelial cells.

As a cardiac anesthesiologist, Dr. Freed is also interested in intraoperative blood pressure control including mechanisms and treatments of vasoplegia. Other interests include translating her work in the lab to improve outcomes for surgical patients.

Healing the Broken Heart With Adrenomedullin.

(Freed JK.) Circ Res. 2019 Jan 04;124(1):15-17.
There is no way to sugar coat it, you are getting older.

(Freed JK, Durand MJ.) Am J Physiol Heart Circ Physiol. 2018 Sep 01;315(3):H632-H633.
Advanced Age Attenuates Left Ventricular Filling Efficiency Quantified Using Vortex Formation Time: A Study of Octogenarians With Normal Left Ventricular Systolic Function Undergoing Coronary Artery Surgery.

(Pagel PS, Dye L 3rd, Boettcher BT, Freed JK.) J Cardiothorac Vasc Anesth. 2018 08;32(4):1775-1779.
A Rare Cause of Intermittent Dyspnea, Occasional Palpitations, and Atypical Chest Discomfort.

(Dye L 3rd, Freed JK, Leschke JR, Pagel PS.) J Cardiothorac Vasc Anesth. 2018 08;32(4):2031-2033.
An Unusual Cause of an Isolated Transient Ischemic Attack in an Otherwise Healthy Elderly Man.

(Freed JK, Simon JA, Iqbal Z, Almassi GH, Pagel PS.) J Cardiothorac Vasc Anesth. 2018 06;32(3):1529-1532.
An Unusual Finding in a Woman Undergoing Resection of a Large Anterior Mediastinal Mass.

(Freed JK, Dyer AJ, Olund TJ, Veldheer DJ, Boettcher BT, Pagel PS.) J Cardiothorac Vasc Anesth. 2018 04;32(2):1090-1092.
Hydroxocobalamin With or Without Methylene Blue May Improve Fluid Balance in Critically Ill Patients With Vasoplegic Syndrome After Cardiac Surgery: A Report of Two Cases.

(Zundel MT, Feih JT, Rinka JRG, Boettcher BT, Freed JK, Kaiser M, Ghadiali HY, Tawil JN, Woehlck HJ, Pagel PS.) J Cardiothorac Vasc Anesth. 2018 02;32(1):452-457.
An Unexpected Finding During Repair of An Ascending Aortic Aneurysm.

(Boettcher BT, Mungara C, Manupipatpong KK, Freed JK, Kaiser M, Pagel PS.) J Cardiothorac Vasc Anesth. 2018 02;32(1):600-602.
Moderate, Short-Term, Local Hyperglycemia Attenuates Forearm Endothelium-Dependent Vasodilation After Transient Ischemia-Reperfusion in Human Volunteers.

(Ebert TJ, Novalija J, Barney JA, Uhrich TD, Arain SR, Freed JK, Pagel PS.) J Cardiothorac Vasc Anesth. 2017 Oct;31(5):1649-1655.
PGC-1α (Peroxisome Proliferator-Activated Receptor γ Coactivator 1-α) Overexpression in Coronary Artery Disease Recruits NO and Hydrogen Peroxide During Flow-Mediated Dilation and Protects Against Increased Intraluminal Pressure.

(Kadlec AO, Chabowski DS, Ait-Aissa K, Hockenberry JC, Otterson MF, Durand MJ, Freed JK, Beyer AM, Gutterman DD.) Hypertension. 2017 07;70(1):166-173.
Communication Is Key: Mechanisms of Intercellular Signaling in Vasodilation.

(Freed JK, Gutterman DD.) J Cardiovasc Pharmacol. 2017 May;69(5):264-272.
Noninvasive Determination of Vortex Formation Time Using Transesophageal Echocardiography During Cardiac Surgery.

(Pagel PS, Dye L 3rd, Hill GED, Vega JL, Tawil JN, De Vry DJ, Chandrashekarappa K, Iqbal Z, Boettcher BT, Freed JK.) J Vis Exp. 2018 11 28(141).

Lab Members

Laura Norwood PhD, Research Scientist
Mary Schulz, Research Technician
Kelsey Walters, Medical Student

Julie Freed