Julie Freed, MD, PhD
Assistant Professor
Contact Information
Education
PhD, Physiology, Medical College of Wisconsin, 2008
MD, Medical College of Wisconsin, 2011
Residency, Anesthesiology, Medical College of Wisconsin, 2016
Fellowship, Cardiac Anesthesiology, Medical College of Wisconsin, 2017
Research Experience
- Adult
- Arterioles
- Coronary Vessels
- Endothelial Cells
- Endothelium, Vascular
- Humans
- Microcirculation
- Nitric Oxide
Clinical Expertise
- Anesthesia, Cardiac Procedures
- Echocardiography, Transesophageal
Leadership Positions
- Director of Clinical Research, Department of Anesthesiology
Research Interests
- Human coronary microvascular dysfunction
- The role of sphingolipids in vascular function
- Mechanisms and treatments of vasoplegia
- Surgical prehabilitation in frail patients
Dr. Freed’s research primarily focuses on the role that sphingolipids have in the development of endothelial dysfunction in the human microcirculation. Elevated plasma levels of ceramide, a prototypical sphingolipid, is now considered an independent risk factor for major adverse cardiovascular events in otherwise healthy people. The Freed lab is currently investigating how these bioactive lipids are regulated in human endothelial cells.
As a cardiac anesthesiologist, Dr. Freed is also interested in intraoperative blood pressure control including mechanisms and treatments of vasoplegia. Other interests include translating her work in the lab to improve outcomes for surgical patients.
For more information, visit Dr. Freed's Lab's informational website.
Publications
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(Pagel PS, Lazicki TJ, Izquierdo DA, Boettcher BT, Tawil JN, Freed JK.) J Cardiothorac Vasc Anesth. 2020 Apr;34(4):857-864 PMID: 31836407 SCOPUS ID: 2-s2.0-85076560651 12/15/2019
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(Pagel PS, Tawil JN, Freed JK.) J Cardiothorac Vasc Anesth. 2019 12;33(12):3406-3408 PMID: 31537403 SCOPUS ID: 2-s2.0-85072186209 09/21/2019
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(Pagel PS, Freed JK, Lien CA.) J Cardiothorac Vasc Anesth. 2019 Dec;33(12):3229-3234 PMID: 31412981 SCOPUS ID: 2-s2.0-85070355320 08/16/2019
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Detrimental effects of chemotherapy on human coronary microvascular function.
(Hader SN, Zinkevich N, Norwood Toro LE, Kriegel AJ, Kong A, Freed JK, Gutterman DD, Beyer AM.) Am J Physiol Heart Circ Physiol. 2019 10 01;317(4):H705-H710 PMID: 31397169 PMCID: PMC6843017 SCOPUS ID: 2-s2.0-85072508643 08/10/2019
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(Schulz ME, Katunaric B, Hockenberry JC, Gutterman DD, Freed JK.) J Am Heart Assoc. 2019 09 03;8(17):e013153 PMID: 31462128 PMCID: PMC6755855 SCOPUS ID: 2-s2.0-85071627825 08/30/2019
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High-Dose Vitamin B12 in Vasodilatory Shock: A Narrative Review.
(Patel JJ, Venegas-Borsellino C, Willoughby R, Freed JK.) Nutr Clin Pract. 2019 Aug;34(4):514-520 PMID: 31187494 SCOPUS ID: 2-s2.0-85067343132 06/13/2019
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(Pagel PS, Freed JK, Lien CA.) J Cardiothorac Vasc Anesth. 2019 03;33(3):593-599 PMID: 30638921 SCOPUS ID: 2-s2.0-85059613187 01/15/2019
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Healing the Broken Heart With Adrenomedullin.
(Freed JK.) Circ Res. 2019 01 04;124(1):15-17 PMID: 30605409 SCOPUS ID: 2-s2.0-85059495332 01/04/2019
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You Are Only as Frail as Your Arteries: Prehabilitation of Elderly Surgical Patients
(Durand MJ, Beckert AK, Peterson CY, Ludwig KA, Ridolfi TJ, Lauer KK, Freed JK.) Current Anesthesiology Reports. 1 December 2019;9(4):380-386 SCOPUS ID: 2-s2.0-85079022988 12/01/2019
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(Pagel PS, Freed JK, Lien CA.) Scientometrics. 2019 SCOPUS ID: 2-s2.0-85069887802 01/01/2019
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(Pagel PS, Dye L 3rd, Hill GED, Vega JL, Tawil JN, De Vry DJ, Chandrashekarappa K, Iqbal Z, Boettcher BT, Freed JK.) J Vis Exp. 2018 11 28(141) PMID: 30582607 SCOPUS ID: 2-s2.0-85058138415 12/26/2018
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There is no way to sugar coat it, you are getting older.
(Freed JK, Durand MJ.) Am J Physiol Heart Circ Physiol. 2018 09 01;315(3):H632-H633 PMID: 29906230 SCOPUS ID: 2-s2.0-85052948336 06/16/2018
Lab Members
- Laura Norwood PhD, Research Scientist
- Mary Schulz, Research Technician
- Kelsey Walters, Medical Student