Staff Collaborate Conference Room

Peter J. Newman, PhD

Peter-Newman-PhD

Peter J. Newman, PhD

Professor; Vice President for Research, BloodCenter of Wisconsin; Associate Director, Blood Research Institute

Locations

  • Pharmacology and Toxicology

Research Interests

Central to the ability of vascular cells to adhere to the extracellular matrix and to each other is an abundant supply of cell surface adhesion molecules that, in addition to influencing the adhesive phenotype of the cell, are also capable of transmitting signals into, and responding to signals from, the cell interior (often referred to an outside/in and inside/out signal transduction, respectively). Such post-ligand events occur by virtue of the ability of these transmembrane proteins to interact with intracellular kinases and phosphatases, G-proteins, adapter proteins, and cytoskeletal components. Our laboratory divides its attention between exploring the role of stimulatory and inhibitory receptors in regulating adhesion and aggregation of human and murine platelets (funded through a Program Project grant), and the structure and function of PECAM-1 in the blood and vascular cells in which it is expressed (funded through a long-standing R01). Techniques range from biochemistry to molecular biology to whole animal models of thrombosis and hemostasis.

Current Grant Support

  • NIH Grant R01 HL40926, years 22-26 - Molecular Biology and Function of PECAM-1
  • NIH Program Project Grant P01-HL44612, years 21-25 (Program Director, Leader, Project 1, and Director of Administrative Core A) - Molecular Mechanisms of Platelet Activation and Adhesion
  • NIH Postdoctoral Training Grant HL-07209 (Co-PI with GC White)

     

  • Ongoing NIH-funded research projects

  • Molecular mechanisms of integrin signaling
  • Integrin/ITAM coupling in platelets and vascular cells
  • Role of PECAM-1 adhesion and signaling in endothelial cell barrier function and vascular permeability
  • Construction of transgenic and knock-in mice expressing variant forms of PECAM-1
  • In vitro microfluidic models of thrombus formation

     

  • Publications