- Medical Director of the Froedtert Surgery center
Recently, a new direction of interest that we are pursuing is to follow up on previously observed strain differences in analgesic/awareness responses to anesthetics that correlates with above-described cardiovascular differences. Using the same animal model, we are interested in identifying genetic differences affecting the regulation of anesthetic-induced alterations of normal physiologic mechanisms that control consciousness. The challenge is to ultimately understand what is different about individuals that are likely to demonstrate anesthetic resistance and to be able to identify those at risk for incomplete loss of consciousness during general anesthesia.
Collectively, our intent is for all of the information that we generate to result in improved anesthetic techniques, particularly in individuals with enhanced sensitivity to these agents.