Cancer Biology and Cancer Research
MD, Bengbu Medical College, 1982
Dr. Qi's Faculty Collaboration Database
Cancer is a leading cause of human death and development of better therapeutics is a major task for cancer research. Nuclear receptors are a group of proteins that act as transcription factors to regulate gene expression in response to ligand treatment. Our major research interest is to explore novel functions of nuclear receptors in regulating therapeutic stress response by dissecting their signaling cross-talk with stress MAPKs.
Our studies have established that vitamin D receptor (VDR) is a stress responsive protein and its expression is induced by stress signaling through c-Jun/AP-1 pathways, which in turn inhibits stress-induced cell death. In human colon cancer cells, K-Ras mutation was shown to inactivate the VDR stress-regulatory pathway leading to an increased cell-death in response to stress p38 MAPK activation. In human breast cancer cells, on the other hand, our studies showed that estrogen receptor (ER) may inhibit stress-induced c-Jun-dependent cell death through a direct protein-protein interaction. These results together suggest that nuclear receptor VDR and ER may have dual biological roles: in response to ligand, they act as a receptor to mediate ligand-induced specific response through transcriptional regulations; in response to stress they function as a cell-death inhibitor through interacting and/or cross-talking with c-Jun-dependent pathways. Regulation of VDR/ER activity may consequently correspond to a novel strategy to increase cancer therapeutic response.
(Hou SW, Zhi HY, Pohl N, Loesch M, Qi XM, Li RS, Basir Z, Chen G.) Cancer Res. 2010 Apr 01;70(7):2901-10.
(Loesch M, Zhi HY, Hou SW, Qi XM, Li RS, Basir Z, Iftner T, Cuenda A, Chen G.) J Biol Chem. 2010 May 14;285(20):15149-58.
(Qi X, Pohl NM, Loesch M, Hou S, Li R, Qin JZ, Cuenda A, Chen G.) J Biol Chem. 2007 Oct 26;282(43):31398-408.
(Li QP, Qi X, Pramanik R, Pohl NM, Loesch M, Chen G.) J Biol Chem. 2007 Jan 19;282(3):1544-51.
(Qi X, Tang J, Loesch M, Pohl N, Alkan S, Chen G.) Cancer Res. 2006 Aug 01;66(15):7540-7.
(Tang J, Qi X, Mercola D, Han J, Chen G.) J Biol Chem. 2005 Jun 24;280(25):23910-7.
(Qi X, Tang J, Pramanik R, Schultz RM, Shirasawa S, Sasazuki T, Han J, Chen G.) J Biol Chem. 2004 May 21;279(21):22138-44.
(Qi X, Borowicz S, Pramanik R, Schultz RM, Han J, Chen G.) J Biol Chem. 2004 Feb 20;279(8):6769-77.
(Pramanik R, Qi X, Borowicz S, Choubey D, Schultz RM, Han J, Chen G.) J Biol Chem. 2003 Feb 14;278(7):4831-9.
(Qi X, Pramanik R, Wang J, Schultz RM, Maitra RK, Han J, DeLuca HF, Chen G.) J Biol Chem. 2002 Jul 19;277(29):25884-92.