Hongwei Yu, MD
Associate Professor
Contact Information
Education
MS, Shandong University Medical School, Jinan, China
Postdoctoral training, Medical University of South Carolina, Charleston, SC
Research Interests
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- Gene and molecular therapy for chronic pain
Publications
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(Shin SM, Cai Y, Itson-Zoske B, Qiu C, Hao X, Xiang H, Hogan QH, Yu H.) Mol Pain. 2020 Jan-Dec;16:1744806920963807 PMID: 33054557 PMCID: PMC7570798 SCOPUS ID: 2-s2.0-85092743914 10/16/2020
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(Shin SM, Itson-Zoske B, Cai Y, Qiu C, Pan B, Stucky CL, Hogan QH, Yu H.) Mol Pain. 2020 Jan-Dec;16:1744806920925425 PMID: 32484015 PMCID: PMC7268132 SCOPUS ID: 2-s2.0-85085909943 06/03/2020
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(La Montanara P, Hervera A, Baltussen LL, Hutson TH, Palmisano I, De Virgiliis F, Kong G, Chadwick J, Gao Y, Bartus K, Majid QA, Gorgoraptis N, Wong K, Downs J, Pizzorusso T, Ultanir SK, Leonard H, Yu H, Millar DS, Istvan N, Mazarakis ND, Di Giovanni S.) Sci Transl Med. 2020 Jul 08;12(551) PMID: 32641489 PMCID: PMC7116442 SCOPUS ID: 2-s2.0-85087720943 07/10/2020
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Sigma-1 receptor activity in primary sensory neurons is a critical driver of neuropathic pain.
(Shin SM, Wang F, Qiu C, Itson-Zoske B, Hogan QH, Yu H.) Gene Ther. 2020 May 18 PMID: 32424233 PMCID: PMC7671947 SCOPUS ID: 2-s2.0-85085190748 05/20/2020
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(Yu H, Shin SM, Xiang H, Chao D, Cai Y, Xu H, Khanna R, Pan B, Hogan QH.) Gene Ther. 2019 08;26(7-8):308-323 PMID: 31118475 PMCID: PMC6707887 SCOPUS ID: 2-s2.0-85066867179 05/24/2019
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(Yu H, Shin SM, Wang F, Xu H, Xiang H, Cai Y, Itson-Zoske B, Hogan QH.) Pain Rep. 2019 Jan-Feb;4(1):e703 PMID: 30801043 PMCID: PMC6370145 SCOPUS ID: 2-s2.0-85061500653 02/26/2019
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(Xiang H, Xu H, Fan F, Shin SM, Hogan QH, Yu H.) J Neurosci Res. 2018 03;96(3):436-448 PMID: 28941260 PMCID: PMC5766685 SCOPUS ID: 2-s2.0-85030181311 09/25/2017
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(Xiang H, Liu Z, Wang F, Xu H, Roberts C, Fischer G, Stucky C, Caron D, Pan B, Hogan Q, Yu H.) Mol Pain. 2017 Jan-Dec;13:1744806917717040 PMID: 28604222 PMCID: PMC5486490 SCOPUS ID: 2-s2.0-85038960017 06/13/2017
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(Fischer G, Wang F, Xiang H, Bai X, Yu H, Hogan QH.) Exp Brain Res. 2017 09;235(9):2627-2638 PMID: 28573310 PMCID: PMC6688185 SCOPUS ID: 2-s2.0-85020124309 06/03/2017
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Dorsal Root Ganglionic Field Stimulation Relieves Spontaneous and Induced Neuropathic Pain in Rats.
(Pan B, Yu H, Fischer GJ, Kramer JM, Hogan QH.) J Pain. 2016 12;17(12):1349-1358 PMID: 27687223 SCOPUS ID: 2-s2.0-84997525072 10/01/2016
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(Wang F, Xiang H, Fischer G, Liu Z, Dupont MJ, Hogan QH, Yu H.) Brain Res. 2016 12 01;1652:62-70 PMID: 27671501 PMCID: PMC5441544 SCOPUS ID: 2-s2.0-84991712739 09/28/2016
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(Liu Z, Wang F, Fischer G, Hogan QH, Yu H.) Mol Pain. 2016;12 PMID: 27145804 PMCID: PMC4956147 SCOPUS ID: 2-s2.0-85007443266 05/06/2016
Satellite glial cells (SGCs) wrapping the primary sensory neurons together compose of unique anatomical and functional sensory units in the DRG. We recently develop a SGC-specific AAV vector (sgcAAV) that is effective in providing SGC-selective transgene expression following intraganglionic sgcAAV delivery in adult rats, and we also developed a microglia-specific AAV vector (mgAAV) by using the promoter of Iba1 gene that is a canonical microglial marker. These glial cell-targeting AAV strategies should prove useful for the development of gene expression systems targeting SGC and microglial signaling for chronic pain. We have also established a dual AAV strategy using two AAV vectors enabling efficient expression of transgenes selectively in neurons versus SGCs.