
Julie Freed, MD, PhD
Associate Professor; Executive Vice Chair; Director of Clinical Research
Contact Information
Education
PhD, Physiology, Medical College of Wisconsin, 2008
MD, Medical College of Wisconsin, 2011
Residency, Anesthesiology, Medical College of Wisconsin, 2016
Fellowship, Cardiac Anesthesiology, Medical College of Wisconsin, 2017
Research Interests
- Human coronary microvascular dysfunction
- The role of sphingolipids in vascular function
- Mechanisms and treatments of vasoplegia
- Surgical prehabilitation in frail patients
Dr. Freed’s research primarily focuses on the role that sphingolipids have in the development of endothelial dysfunction in the human microcirculation. Elevated plasma levels of ceramide, a prototypical sphingolipid, is now considered an independent risk factor for major adverse cardiovascular events in otherwise healthy people. The Freed lab is currently investigating how these bioactive lipids are regulated in human endothelial cells.
As a cardiac anesthesiologist, Dr. Freed is also interested in intraoperative blood pressure control including mechanisms and treatments of vasoplegia. Other interests include translating her work in the lab to improve outcomes for surgical patients.
For more information, visit Dr. Freed's Lab's informational website.
Publications
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17β-Estradiol promotes sex-specific dysfunction in isolated human arterioles.
(SenthilKumar G, Katunaric B, Bordas-Murphy H, Young M, Doren EL, Schulz ME, Widlansky ME, Freed JK.) Am J Physiol Heart Circ Physiol. 2023 Mar 01;324(3):H330-H337 PMID: 36607795 PMCID: PMC9925162 SCOPUS ID: 2-s2.0-85147536237 01/07/2023
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(Patel JJ, Willoughby R, Peterson J, Carver T, Zelten J, Markiewicz A, Spiegelhoff K, Hipp LA, Canales B, Szabo A, Heyland DK, Stoppe C, Zielonka J, Freed JK.) Chest. 2023 Feb;163(2):303-312 PMID: 36174744 SCOPUS ID: 2-s2.0-85146132356 09/30/2022
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New developments in translational microcirculatory research.
(SenthilKumar G, Gutierrez-Huerta CA, Freed JK, Beyer AM, Fancher IS, LeBlanc AJ.) Am J Physiol Heart Circ Physiol. 2022 Dec 01;323(6):H1167-H1175 PMID: 36306213 PMCID: PMC9678417 SCOPUS ID: 2-s2.0-85142403599 10/29/2022
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(Katunaric B, SenthilKumar G, Schulz ME, De Oliveira N, Freed JK.) Hypertension. 2022 Oct;79(10):2250-2261 PMID: 36070401 PMCID: PMC9473289 SCOPUS ID: 2-s2.0-85137486054 09/08/2022
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(Boettcher BT, Woehlck HJ, Makker H, Pagel PS, Freed JK.) Int J Surg Case Rep. 2022 Sep;98:107488 PMID: 35981485 PMCID: PMC9399471 SCOPUS ID: 2-s2.0-85135893802 08/19/2022
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Catheter-based system for the treatment of left ventricular assist device thrombosis.
(Joyce DL, Lynch BE, Freed J, Kreuziger LB, Salinger MH, Joyce LD.) Artif Organs. 2022 Apr;46(4):705-709 PMID: 35080023 SCOPUS ID: 2-s2.0-85124909222 01/27/2022
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(Cohen KE, Katunaric B, Schulz ME, SenthilKumar G, Young MS, Mace JE, Freed JK.) Front Pharmacol. 2022;13:875900 PMID: 35444544 PMCID: PMC9014203 SCOPUS ID: 2-s2.0-85128486794 04/22/2022
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Vascular endothelial adiponectin signaling across the life span.
(Cohen KE, Katunaric B, SenthilKumar G, McIntosh JJ, Freed JK.) Am J Physiol Heart Circ Physiol. 2022 Jan 01;322(1):H57-H65 PMID: 34797171 PMCID: PMC8698498 SCOPUS ID: 2-s2.0-85122249089 11/20/2021
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(Pagel PS, Tawil JN, Boettcher BT, Izquierdo DA, Lazicki TJ, Crystal GJ, Freed JK.) J Cardiothorac Vasc Anesth. 2021 Jun;35(6):1839-1859 PMID: 32747202 SCOPUS ID: 2-s2.0-85089012456 08/05/2020
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(Gaulton TG, Neuman MD, US intubateCOVID Investigators.) Br J Anaesth. 2021 May;126(5):e184-e186 PMID: 33612248 PMCID: PMC8052559 SCOPUS ID: 2-s2.0-85104297993 02/23/2021
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Sweat the small stuff: The human microvasculature and heart disease.
(Katunaric B, Cohen KE, Beyer AM, Gutterman DD, Freed JK.) Microcirculation. 2021 Apr;28(3):e12658 PMID: 32939881 PMCID: PMC7960576 SCOPUS ID: 2-s2.0-85091684344 09/18/2020
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Crossing signals: bioactive lipids in the microvasculature.
(Chabowski DS, Cohen KE, Abu-Hatoum O, Gutterman DD, Freed JK.) Am J Physiol Heart Circ Physiol. 2020 May 01;318(5):H1185-H1197 PMID: 32243770 PMCID: PMC7541955 SCOPUS ID: 2-s2.0-85084166989 04/04/2020
Lab Members
- Laura Norwood PhD, Research Scientist
- Mary Schulz, Research Technician
- Kelsey Walters, Medical Student