Dr. Volkman obtained his Bachelor of Science degree in Chemistry and Physics from Butler University in 1989 and his Doctorate degree from The University of California at Berkeley. The latter was awarded in 1994 for structural studies on proteins involved in bacterial gene regulation using NMR spectroscopy. Dr. Volkman's postdoctoral training was in the Department of Biochemistry at the University of Wisconsin-Madison. In 2000, Dr. Volkman started at the Medical College of Wisconsin where he is Professor in the Biochemistry Department. Dr. Volkman's work focuses on the structural biology of immunological signaling molecules and the use of NMR spectroscopy in structural proteomics.
- Amino Acid Sequence
- Binding Sites
- Chemokine CCL21
- Chemokine CXCL12
- Chemokines, C
- Chemokines, CXC
- Computational Biology
- Crystallography, X-Ray
- Drug Design
Our goal is to invent new ways to treat cancer and other ailments by examining the three-dimensional architecture of proteins involved in disease and synthesizing new drug candidate molecules. This research links the expertise of chemists, structural biologists, and clinician-scientists who collaborate in the design and testing of potential therapies. Graduate students in my group have invented and patented new compounds that show promise as treatments for cancer and psoriasis. Your donation helps us accelerate the drug development process by paying for preclinical studies that most research grants simply won’t support - bridging the gap between our basic science discoveries and clinical trials.
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We use NMR spectroscopy and many other techniques to (1) understand the transmission of biological signals in terms of molecular structure, recognition and dynamics and (2) exploit this knowledge for the design and discovery of new molecules with practical utility as research tools, bioactive nanomaterials, or new drugs.
Dynamics and folding. Protein function is exquisitely dependent on compactly folded structures that combine energetic stability with intrinsic flexibility. Our work has revealed surprising new examples of conformational variability and altered the established paradigm for protein folding to include the new category of ‘metamorphic’ proteins. We are now trying to define the thermodynamic and evolutionary origins of metamorphic folding using the divergence of human lymphotactin from the rest of the chemokine family as a prototypical example. Other projects analyze novel modes of conformational switching that control cell polarity and enzyme activity.
Molecular recognition. Biological signals are often controlled by promoting or disrupting the interaction between two proteins. Many chemokines have been directly implicated in human diseases. Compounds that block chemokine signaling might function as inhibitors of inflammation, cancer progression, viral infection or autoimmune disease. We recently used NMR to solve the structure of the first chemokine-receptor complex, and subsequently used the details of this interface to search for small molecule ligands that bind the chemokine and block its activity. A hybrid in silico/NMR approach to inhibitor screening is now being used to target multiple chemokines with the ultimate goal of drug discovery to treat metastatic cancer and psoriasis.
Back Row L. to R.: Chris Veldkamp, Francis Peterson, Rob Tyler, Anthony Getschman (hands), Austin Jiang,
Alex Chadwick, Davin Jensen, Dustin Whitney and Josh Weiner
Middle Row L. to R.: Chad Koplinski, Amanda Nevins
First Row L. to R.: Dr. Brian Volkman, Echo the dog, Jamie Wieting, Becky Holme
What doesn't kill you makes you stranger: Dipeptidyl peptidase-4 (CD26) proteolysis differentially modulates the activity of many peptide hormones and cytokines generating novel cryptic bioactive ligands.
(Elmansi AM, Awad ME, Eisa NH, Kondrikov D, Hussein KA, Aguilar-Pérez A, Herberg S, Periyasamy-Thandavan S, Fulzele S, Hamrick MW, McGee-Lawrence ME, Isales CM, Volkman BF, Hill WD.) Pharmacol Ther. 2019 06;198:90-108 PMID: 30759373 SCOPUS ID: 2-s2.0-85062148942 02/14/2019
(Kleist AB, Peterson F, Tyler RC, Gustavsson M, Handel TM, Volkman BF.) Methods Cell Biol. 2019;149:259-288 PMID: 30616824 PMCID: PMC6941889 SCOPUS ID: 2-s2.0-85056642454 01/09/2019
(Wedemeyer MJ, Mueller BK, Bender BJ, Meiler J, Volkman BF.) Methods Cell Biol. 2019;149:289-314 PMID: 30616825 PMCID: PMC6790067 SCOPUS ID: 2-s2.0-85055739819 01/09/2019
(Hitchinson B, Eby JM, Gao X, Guite-Vinet F, Ziarek JJ, Abdelkarim H, Lee Y, Okamoto Y, Shikano S, Majetschak M, Heveker N, Volkman BF, Tarasova NI, Gaponenko V.) Sci Signal. 2018 10 16;11(552) PMID: 30327409 PMCID: PMC6422681 SCOPUS ID: 2-s2.0-85055022783 10/18/2018
(Thomas MA, He J, Peterson FC, Huppler AR, Volkman BF.) J Mol Biol. 2018 09 14;430(18 Pt B):3266-3282 PMID: 29913161 PMCID: PMC6103841 SCOPUS ID: 2-s2.0-85049041059 06/19/2018
(Riutta SJ, Larsen O, Getschman AE, Rosenkilde MM, Hwang ST, Volkman BF.) J Leukoc Biol. 2018 08;104(2):423-434 PMID: 30114340 SCOPUS ID: 2-s2.0-85050596102 08/17/2018
(Thomas MA, Kleist AB, Volkman BF.) J Leukoc Biol. 2018 08;104(2):359-374 PMID: 29873835 PMCID: PMC6099250 SCOPUS ID: 2-s2.0-85050644511 06/07/2018
(Dishman AF, Volkman BF.) ACS Chem Biol. 2018 06 15;13(6):1438-1446 PMID: 29787234 PMCID: PMC6007232 SCOPUS ID: 2-s2.0-85047568358 05/23/2018
(Szpakowska M, Nevins AM, Meyrath M, Rhainds D, D'huys T, Guité-Vinet F, Dupuis N, Gauthier PA, Counson M, Kleist A, St-Onge G, Hanson J, Schols D, Volkman BF, Heveker N, Chevigné A.) Br J Pharmacol. 2018 05;175(9):1419-1438 PMID: 29272550 PMCID: PMC5900987 SCOPUS ID: 2-s2.0-85044208341 12/23/2017
(Gao X, Albee LJ, Volkman BF, Gaponenko V, Majetschak M.) Sci Rep. 2018 02 09;8(1):2730 PMID: 29426850 PMCID: PMC5807542 SCOPUS ID: 2-s2.0-85053764631 02/11/2018
(Gao X, Abdelkarim H, Albee LJ, Volkman BF, Gaponenko V, Majetschak M.) PLoS One. 2018;13(9):e0204041 PMID: 30248140 PMCID: PMC6152952 SCOPUS ID: 2-s2.0-85053768829 09/25/2018
(Albee LJ, LaPorte HM, Gao X, Eby JM, Cheng YH, Nevins AM, Volkman BF, Gaponenko V, Majetschak M.) Open Biol. 2018 01;8(1) PMID: 29386406 PMCID: PMC5795052 SCOPUS ID: 2-s2.0-85053785091 02/02/2018