Research Collaborate Lab Bench
Brian Smith

Brian Smith, PhD

Associate Director, Program in Chemical Biology; Associate Professor, Biochemistry


  • Biochemistry
    BSB 356

Contact Information


PhD, University of Wisconsin - Madison, 2008
BS, University of Illinois at Urbana-Champaign, 2003


Dr. Smith received his Bachelor of Science in Chemistry from the University of Illinois at Urbana-Champaign in 2003. He then received his PhD in Chemistry from the University of Wisconsin-Madison in 2008, where his research focused on the chemical mechanisms of sirtuin protein lysine deacetylases. During his graduate career he spent a brief period at Genentech in the Department of Medicinal Chemistry where he synthesized drugs that target the Inhibitor of Apoptosis family of proteins. From 2009-2014, Dr. Smith performed postdoctoral studies on nitric oxide synthases and cysteine S-nitrosation at the University of California, Berkeley and the Scripps Research Institute in La Jolla. During his postdoctoral studies Dr. Smith was awarded an NIH Ruth L. Kirschstein National Research Service Award. Dr. Smith joined the faculty at the Medical College of Wisconsin in 2014.

Research Experience

  • Alkylating Agents
  • Amino Acids, Peptides, and Proteins
  • Binding Sites
  • Biochemistry
  • Catalysis
  • Deuterium Exchange Measurement
  • Enzyme Activators
  • Enzyme Inhibitors
  • Enzymes and Coenzymes
  • Histone Code
  • Histone Deacetylases
  • Mass Spectrometry

Methodologies and Techniques

  • Biochemistry
  • Biological Assay
  • chemical synthesis
  • Chromatography, Affinity
  • Electrophoresis
  • enzymology
  • Mass Spectrometry
  • Models, Chemical
  • Models, Molecular
  • Mutagenesis
  • Nuclear Magnetic Resonance, Biomolecular
  • Peptide Library

MCW Program / Core Facilities

  • Biochemistry
  • Redox Biology