Brian Smith, PhD

Associate Professor

Locations

Biochemistry
BSB 356

Contact Information

Education

PhD, University of Wisconsin - Madison, 2008
BS, University of Illinois at Urbana-Champaign, 2003

Please see the Smith lab website for more information

Biography

Dr. Smith received his Bachelor of Science in Chemistry from the University of Illinois at Urbana-Champaign in 2003. He then received his PhD in Chemistry from the University of Wisconsin-Madison in 2008, where his research focused on the chemical mechanisms of sirtuin protein lysine deacetylases. During his graduate career he spent a brief period at Genentech in the Department of Medicinal Chemistry where he synthesized drugs that target the Inhibitor of Apoptosis family of proteins. From 2009-2014, Dr. Smith performed postdoctoral studies on nitric oxide synthases and cysteine S-nitrosation at the University of California, Berkeley and the Scripps Research Institute in La Jolla. During his postdoctoral studies Dr. Smith was awarded an NIH Ruth L. Kirschstein National Research Service Award. Dr. Smith joined the faculty at the Medical College of Wisconsin in 2014.

                
                    Research Experience
                

                    Alkylating Agents
Amino Acids, Peptides, and Proteins
Binding Sites
Biochemistry
Catalysis
Deuterium Exchange Measurement
Enzyme Activators
Enzyme Inhibitors
Enzymes and Coenzymes
Histone Code
Histone Deacetylases
Mass Spectrometry

            

                
                    Methodologies and Techniques
                

                    Biochemistry
Biological Assay
chemical synthesis
Chromatography, Affinity
Electrophoresis
enzymology
Mass Spectrometry
Models, Chemical
Models, Molecular
Mutagenesis
Nuclear Magnetic Resonance, Biomolecular
Peptide Library

            

                
                    MCW Program / Core Facilities
                

                    Biochemistry
Redox Biology

            

Pharmacological inhibition of the acetyltransferase Tip60 mitigates myocardial infarction injury.

(Wang X, Wan TC, Kulik KR, Lauth A, Smith BC, Lough JW, Auchampach JA.) Dis Model Mech. 2023 May 01;16(5) PMID: 36341679 PMCID: PMC9672930 SCOPUS ID: 2-s2.0-85141362492 11/08/2022
Oral and Inhaled Fosamprenavir Reverses Pepsin-Induced Damage in a Laryngopharyngeal Reflux Mouse Model.

(Johnston N, Samuels TL, Goetz CJ, Arnold LA, Smith BC, Seabloom D, Wuertz B, Ondrey F, Wiedmann TS, Vuksanovic N, Silvaggi NR, MacKinnon AC, Miller J, Bock J, Blumin JH.) Laryngoscope. 2023 Jan;133 Suppl 1(Suppl 1):S1-S11 PMID: 35678265 PMCID: PMC9732152 SCOPUS ID: 2-s2.0-85131512635 06/10/2022
Fluorinated triphenylphosphonium analogs improve cell selectivity and in vivo detection of mito-metformin.

(AbuEid M, Keyes RF, McAllister D, Peterson F, Kadamberi IP, Sprague DJ, Chaluvally-Raghavan P, Smith BC, Dwinell MB.) iScience. 2022 Dec 22;25(12):105670 PMID: 36567718 PMCID: PMC9768319 12/27/2022
Selective and Cell-Active PBRM1 Bromodomain Inhibitors Discovered through NMR Fragment Screening.

(Shishodia S, Nuñez R, Strohmier BP, Bursch KL, Goetz CJ, Olp MD, Jensen DR, Fenske TG, Ordonez-Rubiano SC, Blau ME, Roach MK, Peterson FC, Volkman BF, Dykhuizen EC, Smith BC.) J Med Chem. 2022 Oct 27;65(20):13714-13735 PMID: 36227159 PMCID: PMC9630929 SCOPUS ID: 2-s2.0-85140311972 10/14/2022
Characterization of Dual-Acting A3 Adenosine Receptor Positive Allosteric Modulators That Preferentially Enhance Adenosine-Induced Gαi3 and GαoA Isoprotein Activation.

(Fisher CL, Fallot LB, Wan TC, Keyes RF, Suresh RR, Rothwell AC, Gao ZG, McCorvy JD, Smith BC, Jacobson KA, Auchampach JA.) ACS Pharmacol Transl Sci. 2022 Aug 12;5(8):625-641 PMID: 35983277 PMCID: PMC9380209 08/20/2022
Characterization of Novel A3 Adenosine Receptor Allosteric Modulators.

(Fisher CL, Wan TC, Fallot LB, Keyes RF, Suresh RR, Rothwell AC, Gao ZG, McCorvy JD, Smith BC, Jacobson KA, Auchampach JA.) FASEB J. 2022 May;36 Suppl 1 PMID: 35552611 SCOPUS ID: 2-s2.0-85130052937 05/14/2022
Zinc-Chelating BET Bromodomain Inhibitors Selectively Accumulate and Affect Gene Expression in Pancreatic β-Cells.

(Jones Lipinski RA, Stancill JS, Wynia-Smith SL, Sprague DJ, Nunez R, Bird A, Corbett JA, Smith BC.) FASEB J. 2022 May;36 Suppl 1 PMID: 35552609 05/14/2022
Chemical Regulation of the Protein Quality Control E3 Ubiquitin Ligase C-Terminus of Hsc70 Interacting Protein (CHIP).

(Kanack AJ, Olp MD, Newsom OJ, Scaglione JB, Gooden DM, McMahon K, Smith BC, Scaglione KM.) Chembiochem. 2022 Mar 18;23(6):e202100633 PMID: 35061295 PMCID: PMC9016715 01/22/2022
N-terminal BET bromodomain inhibitors disrupt a BRD4-p65 interaction and reduce inducible nitric oxide synthase transcription in pancreatic β-cells.

(Nord JA, Wynia-Smith SL, Gehant AL, Jones Lipinski RA, Naatz A, Rioja I, Prinjha RK, Corbett JA, Smith BC.) Front Endocrinol (Lausanne). 2022;13:923925 PMID: 36176467 PMCID: PMC9513428 10/01/2022
Structural bioinformatics enhances the interpretation of somatic mutations in KDM6A found in human cancers.

(Chi YI, Stodola TJ, De Assuncao TM, Leverence EN, Smith BC, Volkman BF, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R.) Comput Struct Biotechnol J. 2022;20:2200-2211 PMID: 35615018 PMCID: PMC9111933 SCOPUS ID: 2-s2.0-85130080827 05/27/2022
Trisubstituted 1,3,5-Triazines: The First Ligands of the sY12-Binding Pocket on Chemokine CXCL12.

(Sprague DJ, Getschman AE, Fenske TG, Volkman BF, Smith BC.) ACS Med Chem Lett. 2021 Nov 11;12(11):1773-1782 PMID: 34795867 PMCID: PMC8592115 11/20/2021
Sirtuin Oxidative Post-translational Modifications.

(Kalous KS, Wynia-Smith SL, Smith BC.) Front Physiol. 2021;12:763417 PMID: 34899389 PMCID: PMC8652059 12/14/2021

Brian Smith, PhD

Associate Professor

Locations

Contact Information

Education

Biography

Research Experience

Methodologies and Techniques

MCW Program / Core Facilities

Publications