Brian Smith, PhD

Associate Director, Program in Chemical Biology; Associate Professor, Biochemistry

Locations

Biochemistry
BSB 356

Contact Information

Education

PhD, University of Wisconsin - Madison, 2008
BS, University of Illinois at Urbana-Champaign, 2003

Please see the Smith lab website for more information

Biography

Dr. Smith received his Bachelor of Science in Chemistry from the University of Illinois at Urbana-Champaign in 2003. He then received his PhD in Chemistry from the University of Wisconsin-Madison in 2008, where his research focused on the chemical mechanisms of sirtuin protein lysine deacetylases. During his graduate career he spent a brief period at Genentech in the Department of Medicinal Chemistry where he synthesized drugs that target the Inhibitor of Apoptosis family of proteins. From 2009-2014, Dr. Smith performed postdoctoral studies on nitric oxide synthases and cysteine S-nitrosation at the University of California, Berkeley and the Scripps Research Institute in La Jolla. During his postdoctoral studies Dr. Smith was awarded an NIH Ruth L. Kirschstein National Research Service Award. Dr. Smith joined the faculty at the Medical College of Wisconsin in 2014.

Cysteine and methionine oxidation in thrombotic disorders.

(Yang M, Smith BC.) Curr Opin Chem Biol. 2023 Oct;76:102350 PMID: 37331217 PMCID: PMC10527720 06/19/2023
Sulfenylation links oxidative stress to protein disulfide isomerase oxidase activity and thrombus formation.

(Yang M, Chiu J, Scartelli C, Ponzar N, Patel S, Patel A, Ferreira RB, Keyes RF, Carroll KS, Pozzi N, Hogg PJ, Smith BC, Flaumenhaft R.) J Thromb Haemost. 2023 Aug;21(8):2137-2150 PMID: 37037379 04/11/2023
Fragment-based drug discovery of small molecule ligands for the human chemokine CCL28.

(Zhou AL, Jensen DR, Peterson FC, Thomas MA, Schlimgen RR, Dwinell MB, Smith BC, Volkman BF.) SLAS Discov. 2023 Jun;28(4):163-169 PMID: 36841432 PMCID: PMC10339762 SCOPUS ID: 2-s2.0-85149845436 02/26/2023
Pharmacological inhibition of the acetyltransferase Tip60 mitigates myocardial infarction injury.

(Wang X, Wan TC, Kulik KR, Lauth A, Smith BC, Lough JW, Auchampach JA.) Dis Model Mech. 2023 May 01;16(5) PMID: 36341679 PMCID: PMC9672930 SCOPUS ID: 2-s2.0-85141362492 11/08/2022
Beyond Structural Bioinformatics for Genomics with Dynamics Characterization of an Expanded KRAS Mutational Landscape.

(Ratnasinghe BD, Haque N, Wagenknecht JB, Jensen DR, Esparza GV, Leverence EN, De Assuncao TM, Mathison AJ, Lomberk G, Smith BC, Volkman BF, Urrutia R, Zimmermann MT.) bioRxiv. 2023 Apr 28 PMID: 37207265 PMCID: PMC10189839 05/19/2023
Harnessing the Noncanonical Keap1-Nrf2 Pathway for Human Cytomegalovirus Control.

(Ghosh AK, Su YP, Forman M, Keyes RF, Smith BC, Hu X, Ferrer M, Arav-Boger R.) J Virol. 2023 Apr 27;97(4):e0016023 PMID: 36939350 PMCID: PMC10134830 SCOPUS ID: 2-s2.0-85159161803 03/21/2023
Oral and Inhaled Fosamprenavir Reverses Pepsin-Induced Damage in a Laryngopharyngeal Reflux Mouse Model.

(Johnston N, Samuels TL, Goetz CJ, Arnold LA, Smith BC, Seabloom D, Wuertz B, Ondrey F, Wiedmann TS, Vuksanovic N, Silvaggi NR, MacKinnon AC, Miller J, Bock J, Blumin JH.) Laryngoscope. 2023 Jan;133 Suppl 1(Suppl 1):S1-S11 PMID: 35678265 PMCID: PMC9732152 SCOPUS ID: 2-s2.0-85131512635 06/10/2022
Fluorinated triphenylphosphonium analogs improve cell selectivity and in vivo detection of mito-metformin.

(AbuEid M, Keyes RF, McAllister D, Peterson F, Kadamberi IP, Sprague DJ, Chaluvally-Raghavan P, Smith BC, Dwinell MB.) iScience. 2022 Dec 22;25(12):105670 PMID: 36567718 PMCID: PMC9768319 12/27/2022
Selective and Cell-Active PBRM1 Bromodomain Inhibitors Discovered through NMR Fragment Screening.

(Shishodia S, Nuñez R, Strohmier BP, Bursch KL, Goetz CJ, Olp MD, Jensen DR, Fenske TG, Ordonez-Rubiano SC, Blau ME, Roach MK, Peterson FC, Volkman BF, Dykhuizen EC, Smith BC.) J Med Chem. 2022 Oct 27;65(20):13714-13735 PMID: 36227159 PMCID: PMC9630929 SCOPUS ID: 2-s2.0-85140311972 10/14/2022
Characterization of Dual-Acting A3 Adenosine Receptor Positive Allosteric Modulators That Preferentially Enhance Adenosine-Induced Gαi3 and GαoA Isoprotein Activation.

(Fisher CL, Fallot LB, Wan TC, Keyes RF, Suresh RR, Rothwell AC, Gao ZG, McCorvy JD, Smith BC, Jacobson KA, Auchampach JA.) ACS Pharmacol Transl Sci. 2022 Aug 12;5(8):625-641 PMID: 35983277 PMCID: PMC9380209 08/20/2022
N-terminal BET bromodomain inhibitors disrupt a BRD4-p65 interaction and reduce inducible nitric oxide synthase transcription in pancreatic β-cells.

(Nord JA, Wynia-Smith SL, Gehant AL, Jones Lipinski RA, Naatz A, Rioja I, Prinjha RK, Corbett JA, Smith BC.) Front Endocrinol (Lausanne). 2022;13:923925 PMID: 36176467 PMCID: PMC9513428 10/01/2022
Structural bioinformatics enhances the interpretation of somatic mutations in KDM6A found in human cancers.

(Chi YI, Stodola TJ, De Assuncao TM, Leverence EN, Smith BC, Volkman BF, Mathison AJ, Lomberk G, Zimmermann MT, Urrutia R.) Comput Struct Biotechnol J. 2022;20:2200-2211 PMID: 35615018 PMCID: PMC9111933 SCOPUS ID: 2-s2.0-85130080827 05/27/2022