Nathan A. Ledeboer, PhD

Professor; Medical Director, Clinical Microbiology; Medical Director, Molecular Diagnostics

Locations

Pathology & Laboratory Medicine

Contact Information

Biography

Dr. Ledeboer’s primary responsibility is for the medical and technical oversight of the Clinical Microbiology and Molecular Diagnostics Laboratories. In this role he oversees development and implementation of new assays, oversees and sign out all testing performed in these laboratories, and consults with physician colleagues regarding test results and selection.

Specialties:

Clinical Microbiology
Molecular Pathology

Research Interests

Development of rapid molecular techniques for detection of infectious diseases

Host Response to Infection

Combining Digital Imaging and Artificial Intelligence

Molecular detection and epidemiology of Respiratory Viruses

Antimicrobial resistance

Cytotoxic CD8-positive T-lymphocyte infiltration in the lungs as a histological pattern of SARS-CoV-2 pneumonitis.

(Puzyrenko A, Felix JC, Ledeboer NA, Sun Y, Rui H, Sheinin Y.) Pathology. 2022 Jun;54(4):404-408 PMID: 34836647 PMCID: PMC8572726 SCOPUS ID: 2-s2.0-85119915379 11/28/2021
Surveillance cultures following a regional outbreak of carbapenem-resistant Acinetobacter baumannii.

(Rivera F, Reeme A, Graham MB, Buchan BW, Ledeboer NA, Valley AM, Munoz-Price LS.) Infect Control Hosp Epidemiol. 2022 Apr;43(4):454-460 PMID: 33985611 SCOPUS ID: 2-s2.0-85105848855 05/15/2021
Rapid identification from rectal swabs of the clinically most relevant carbapenemase genes from gram-negative bacteria using the BD MAX Check-Points CPO Assay.

(García-Fernández S, Simner PJ, Thomson G, Faron M, Bosboom R, van Griethuijsen A, García-Castillo M, Harris R, Ledeboer NA, Cantón R, Thomson KS.) Diagn Microbiol Infect Dis. 2022 Jan;102(1):115554 PMID: 34678712 SCOPUS ID: 2-s2.0-85117421272 10/23/2021
Response to SARS-CoV-2 vaccination in patients after hematopoietic cell transplantation and CAR T-cell therapy.

(Dhakal B, Abedin S, Fenske T, Chhabra S, Ledeboer N, Hari P, Hamadani M.) Blood. 2021 Oct 07;138(14):1278-1281 PMID: 34339501 PMCID: PMC8332674 SCOPUS ID: 2-s2.0-85114112109 08/03/2021
Can a Clean Catch Urine Sample Be Used to Diagnose Chlamydia and Gonorrhea in Adolescent Females?

(Pickett ML, Visotcky A, Brazauskas R, Ledeboer NA, Drendel AL.) J Adolesc Health. 2021 Oct;69(4):574-578 PMID: 33846057 SCOPUS ID: 2-s2.0-85104082927 04/14/2021
A Novel Multiplexed Enzyme-Linked Immunosorbent Assay for the Detection of IgG Seroreactivity to Cytomegalovirus (CMV) UL144.

(Miller H, Simpson P, Forman M, Prigan A, Kehl S, Mesich B, Faron M, Ledeboer N, Arav-Boger R.) J Clin Microbiol. 2021 Jul 19;59(8):e0096421 PMID: 34076473 PMCID: PMC8373222 SCOPUS ID: 2-s2.0-85112127278 06/03/2021
Evaluation of a High-Definition PCR Assay for the Detection of SARS-CoV-2 in Extracted and Nonextracted Respiratory Specimens Collected in Various Transport Media.

(Buchan BW, Gerstbrein D, Cruz A, Hoff J, Sievert E, Ledeboer NA, Faron ML.) Am J Clin Pathol. 2021 Jun 17;156(1):24-33 PMID: 33940605 PMCID: PMC8135719 SCOPUS ID: 2-s2.0-85108387082 05/04/2021
Point-of-care COVID-19 testing in the emergency department: current status and future prospects

(May L, Tran N, Ledeboer NA.) Expert Review of Molecular Diagnostics. 2021;21(12):1333-1340 SCOPUS ID: 2-s2.0-85120077883 01/01/2021
Digital Image Analysis for the Detection of Group B Streptococcus from ChromID Strepto B Medium Using PhenoMatrix Algorithms.

(Baker J, Timm K, Faron M, Ledeboer N, Culbreath K.) J Clin Microbiol. 2020 Dec 17;59(1) PMID: 33087433 PMCID: PMC7771474 SCOPUS ID: 2-s2.0-85098517412 10/23/2020
A Multi-mRNA Host-Response Molecular Blood Test for the Diagnosis and Prognosis of Acute Infections and Sepsis: Proceedings from a Clinical Advisory Panel.

(Ducharme J, Self WH, Osborn TM, Ledeboer NA, Romanowsky J, Sweeney TE, Liesenfeld O, Rothman RE.) J Pers Med. 2020 Dec 07;10(4) PMID: 33297498 PMCID: PMC7762405 12/11/2020
Decrease in Positivity Rate of Influenza Tests Coinciding With Outbreak of SARS-CoV-2: Data From a Southeastern Wisconsin Laboratory.

(Singh S, Ledeboer NA, Laud PW, Hanson R, Truwit JD.) WMJ. 2020 Dec;119(4):275-277 PMID: 33428839 SCOPUS ID: 2-s2.0-85099899804 01/12/2021
Racial Disparities in Incidence and Outcomes Among Patients With COVID-19.

(Muñoz-Price LS, Nattinger AB, Rivera F, Hanson R, Gmehlin CG, Perez A, Singh S, Buchan BW, Ledeboer NA, Pezzin LE.) JAMA Netw Open. 2020 Sep 01;3(9):e2021892 PMID: 32975575 PMCID: PMC7519420 SCOPUS ID: 2-s2.0-85091807867 09/26/2020