
Christopher M. Olsen, PhD
Associate Professor
Locations
- Pharmacology and Toxicology
Contact Information
General Interests
Education
MS, Texas Tech University, 1998
BA, Baylor University, 1994
Research Interests
Olsen Lab
Addiction is a chronically relapsing disorder that is strongly modulated by positive and negative environmental factors. Our lab (olsenlab.org) focuses on how these environmental factors can influence drug intake and drug seeking using rat and mouse models of addiction.
We have two major projects to investigate environmental factors and addiction:
Environmental modulation of drug seeking ensembles. Transgenic approaches are used to identify and manipulate cells that are engaged during drug seeking following intravenous drug self-administration. We are studying the effects of positive and negative environmental factors on drug seeking and the activity of cells within drug seeking ensembles.
The impact of mild traumatic brain injury (mTBI) on addiction and mesocorticolimbic function. This work is done in collaboration with Drs. Brain Stemper and Matthew Budde in the Department of Biomedical Engineering and Neurosurgery, respectively. We are examining the effects of mTBI on drug self-administration, drug seeking, and mesocorticolimbic function using diffusion tensor imaging (DTI) and functional connectivity.
View the full publication list.
Identification of neuronal ensembles involved in persistent drug seeking. TetTag (green) cells are those engaged during an initial drug seeking session, Fos+ (red) cells are those engaged during a second drug seeking session 2 weeks later.
Quantification of monocytes/microglia. Iba1+ (green) cells are surface rendered for complex analysis to examine long-lasting effect of mild traumatic brain injury on immune cells within the brain. Gray=nuclei (DAPI).
Publications
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(Jessen K, Slaker Bennett ML, Liu S, Olsen CM.) J Neurosci Res. 2022 Apr;100(4):1008-1029 PMID: 35137974 PMCID: PMC8940716 02/10/2022
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Does Traumatic Brain Injury Cause Risky Substance Use or Substance Use Disorder?
(Olsen CM, Corrigan JD.) Biol Psychiatry. 2022 Mar 01;91(5):421-437 PMID: 34561027 PMCID: PMC8776913 09/26/2021
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(Raber J, Holden S, Sudhakar R, Hall R, Glaeser B, Lenarczyk M, Rockwell K, Nawarawong N, Sterrett J, Perez R, Leonard SW, Morré J, Choi J, Kronenberg A, Borg A, Kwok A, Stevens JF, Olsen CM, Willey JS, Bobe G, Baker J.) Front Physiol. 2021;12:746509 PMID: 34646164 PMCID: PMC8503608 SCOPUS ID: 2-s2.0-85116920048 10/15/2021
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(Nawarawong NN, Olsen CM.) Behav Brain Res. 2020 Feb 03;379:112275 PMID: 31614186 PMCID: PMC7937550 10/16/2019
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(Nawarawong NN, Slaker M, Muelbl M, Shah AS, Chiariello R, Nelson LD, Budde MD, Stemper BD, Olsen CM.) Eur J Neurosci. 2019 Aug;50(3):2101-2112 PMID: 30456793 PMCID: PMC6814147 SCOPUS ID: 2-s2.0-85058419226 11/21/2018
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Effects of Mild Blast Traumatic Brain Injury on Cognitive- and Addiction-Related Behaviors.
(Muelbl MJ, Slaker ML, Shah AS, Nawarawong NN, Gerndt CH, Budde MD, Stemper BD, Olsen CM.) Sci Rep. 2018 Jul 02;8(1):9941 PMID: 29967344 PMCID: PMC6028456 SCOPUS ID: 2-s2.0-85049369592 07/04/2018
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(Pan J, Lee Y, Cheng G, Zielonka J, Zhang Q, Bajzikova M, Xiong D, Tsaih SW, Hardy M, Flister M, Olsen CM, Wang Y, Vang O, Neuzil J, Myers CR, Kalyanaraman B, You M.) iScience. 2018 May 25;3:192-207 PMID: 30428319 PMCID: PMC6137433 11/15/2018
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(Nelson LD, Furger RE, Ranson J, Tarima S, Hammeke TA, Randolph C, Barr WB, Guskiewicz K, Olsen CM, Lerner EB, McCrea MA.) J Neurotrauma. 2018 Jan 15;35(2):249-259 PMID: 29017409 PMCID: PMC5784791 SCOPUS ID: 2-s2.0-85041086882 10/12/2017
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(Helfand AI, Olsen CM, Hillard CJ.) Int J Mol Sci. 2017 Jul 27;18(8) PMID: 28749428 PMCID: PMC5578025 SCOPUS ID: 2-s2.0-85026663350 07/28/2017
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(Stemper B.D., Shah A.S., Budde M.D., Chiariello R., Wilkins N., Olsen C., Mehta P., Kurpad S.N., McCrea M., Pintar F.A. .) 2015 IRCOBI Conference Proceedings. 198-207 09/06/2017
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(LD Nelson, RE Furger, J Ranson, S Tarima, TA Hammeke, C Randolph, WB Barr, K Guskiewicz, CM Olsen, EB Lerner, and MA McCrea.) Journal of Neurotrauma. (in press) 09/06/2017
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Phosphodiesterase 4 inhibitors and drugs of abuse: current knowledge and therapeutic opportunities.
(Olsen CM, Liu QS.) Front Biol (Beijing). 2016 Oct;11(5):376-386 PMID: 28974957 PMCID: PMC5617368 10/05/2017