David A. A. Baranger, PhD
Assistant Professor
Locations
- MFRC 3040
Contact Information
Education
Postdoctoral Fellowship, University of Pittsburgh, 2021
PhD, Washington University in St. Louis, 2018
BA, Wesleyan University, 2010
Biography
Dr. David Baranger is a neuroscientist studying the causes and consequences of substance use. He received his PhD in Neuroscience from Washington University in St. Louis, under the mentorship of Drs. Ryan Bogdan and Deanna Barch. His work was supported in part by an NSF GRFP, and his dissertation was on the use of neural biomarkers to disentangle the causes and downstream consequences of alcohol use. He first completed a postdoc at the University of Pittsburgh, with Drs. Erika Forbes and Anna Manelis, where he studied neural correlates of depression using longitudinal and machine learning analyses. He then completed a second postdoc with Drs. Arpana Agrawal and Ryan Bogdan at Washington University in St. Louis, supported by a NIAAA K99/R00, where he studied the causes and consequences of substance and alcohol use across development, using neuroimaging and statistical genetics. In 2025, Dr. Baranger moved to Milwaukee and launched his independent lab at the Medical College of Wisconsin in the Department of Cell Pharmacology and Toxicology. Undergraduate, graduate, and postdoctoral trainees who are enthusiastic about addiction neuroscience and interested in joining the Baranger Lab are encouraged to reach out to Dr. Baranger at dbaranger@mcw.edu.
Research Areas of Interest
- Adolescent
- Alcoholic Intoxication
- Alcoholism
- Brain
- Cannabis
- Child
- Cognition
- Genetic Predisposition to Disease
- Genome-Wide Association Study
- Humans
- Longitudinal Studies
- Machine Learning
Methodologies and Techniques
- Adolescent
- Adult
- Alcohol Abstinence
- Alcohol Drinking
- Alcoholic Beverages
- Alcoholic Intoxication
- Alcoholics
- Brain
- Cannabis
- Child
- Genome-Wide Association Study
- Humans
Research Interests
Substance use is a global health problem that is most likely to onset during adolescence/young adulthood. High rates of substance use and abuse during this developmental period are theorized to arise from normative patterns of age-related neural maturation impacting impulsivity, negative affect, and cognition. Substance use may then subsequently induce neural and behavioral changes within these circuits to further drive continued and escalating use. The Baranger Lab seeks to disentangle the developmental and predispositional origin of substance use disorders from their causal effects on the brain, with a focus on alcohol and cannabis use. We use a multi-method approach, including self-report, behavior, human neuroimaging, and genomic analyses, in adolescents and young adults, in both clinical and healthy populations. In addition to collecting data to target specific hypotheses, we use large-scale datasets that allow for rigorous data-driven approaches.
Publications
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(Johnson EC, Lai D, Balbona JV, Miller AP, Hatoum AS, Deak JD, Jennings M, Baranger DAA, Galimberti M, Sanichwankul K, Thorgeirsson T, Colbert SMC, Adhikari K, Docherty AR, Degenhardt L, Edwards T, Fox L, Giannelis A, Jeffries PW, Korhonen T, Morrison CL, Nunez YZ, Palviainen T, Su MH, Romero Villela PN, Wetherill L, Willoughby EA, Zellers SM, Bierut LJ, Buchwald J, Copeland WE, Corley RP, Friedman NP, Foroud TM, Gillespie NA, Gizer IR, Heath AC, Hickie IB, Kaprio J, Keller MC, Lee JJ, Lind P, Madden PA, Maes HHM, Martin NG, McGue M, Medland SE, Nelson EC, Pearson J, Porjesz B, Stallings MC, Vrieze S, Wilhelmson KC, Kranzler HR, Walters RK, Polimanti R, Malison R, Zhou H, Stefansson K, Sanchez-Roige S, Potenza M, Mutirangura A, Shotelersuk V, Kalayasiri R, Edenberg HJ, Gelernter J, Agrawal A.) Psychol Med. 2025 Aug 20;55:e234 PMID: 40831304 PMCID: PMC12360691 SCOPUS ID: 2-s2.0-105013552891 08/20/2025
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(Norton SA, Gorelik AJ, Paul SE, Johnson EC, Baranger DA, Siudzinski JL, Li ZA, Bondy E, Modi H, Karcher NR, Hershey T, Hatoum AS, Agrawal A, Bogdan R.) Brain Behav Immun. 2025 Aug;128:487-496 PMID: 40228565 PMCID: PMC12264583 SCOPUS ID: 2-s2.0-105003868963 04/15/2025
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(Hatoum AS, Gorelik AJ, Blaydon L, Huggett SB, Chi T, Baranger DAA, Miller AP, Johnson EC, Agrawal A, Bogdan R.) Commun Med (Lond). 2025 May 16;5(1):176 PMID: 40379965 PMCID: PMC12084526 05/17/2025
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Enhancing task fMRI individual difference research with neural signatures.
(Baranger DA, Gorelik AJ, Paul SE, Hatoum AS, Dosenbach N, Bogdan R.) medRxiv. 2025 Jan 31 PMID: 39974058 PMCID: PMC11838658 02/20/2025
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(Modi H, Baranger DAA, Paul SE, Gorelik AJ, Hornstein A, Balbona JV, Agrawal A, Bijsterbosch JD, Bogdan R.) Neurotoxicol Teratol. 2025;107:107404 PMID: 39592017 PMCID: PMC12226004 SCOPUS ID: 2-s2.0-85212536960 11/27/2024
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Neuroanatomical Variability and Substance Use Initiation in Late Childhood and Early Adolescence.
(Miller AP, Baranger DAA, Paul SE, Garavan H, Mackey S, Tapert SF, LeBlanc KH, Agrawal A, Bogdan R.) JAMA Netw Open. 2024 Dec 02;7(12):e2452027 PMID: 39786408 PMCID: PMC11686416 SCOPUS ID: 2-s2.0-85214355662 01/09/2025
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(Gorelik AJ, Paul SE, Miller AP, Baranger DAA, Lin S, Zhang W, Elsayed NM, Modi H, Addala P, Bijsterbosch J, Barch DM, Karcher NR, Hatoum AS, Agrawal A, Bogdan R, Johnson EC.) Psychol Med. 2024 Oct 23;54(13):1-15 PMID: 39440454 PMCID: PMC11536102 10/23/2024
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Cross-ancestry genetic investigation of schizophrenia, cannabis use disorder, and tobacco smoking.
(Johnson EC, Austin-Zimmerman I, Thorpe HHA, Levey DF, Baranger DAA, Colbert SMC, Demontis D, Khokhar JY, Davis LK, Edenberg HJ, Di Forti M, Sanchez-Roige S, Gelernter J, Agrawal A.) Neuropsychopharmacology. 2024 Oct;49(11):1655-1665 PMID: 38906991 PMCID: PMC11399264 SCOPUS ID: 2-s2.0-85195662883 06/22/2024
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Kappa opioids inhibit spinal output neurons to suppress itch.
(Sheahan TD, Warwick CA, Cui AY, Baranger DAA, Perry VJ, Smith KM, Manalo AP, Nguyen EK, Koerber HR, Ross SE.) Sci Adv. 2024 Sep 27;10(39):eadp6038 PMID: 39321286 PMCID: PMC11423883 SCOPUS ID: 2-s2.0-85204941573 09/25/2024
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Prenatal cannabis exposure, the brain, and psychopathology during early adolescence.
(Baranger DA, Miller AP, Gorelik AJ, Paul SE, Hatoum AS, Johnson EC, Colbert SM, Smyser CD, Rogers CE, Bijsterbosch JD, Agrawal A, Bogdan R.) Nat Ment Health. 2024 Aug;2(8):975-986 PMID: 40836962 PMCID: PMC12363474 08/21/2025
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(Paul SE, Baranger DAA, Johnson EC, Jackson JJ, Gorelik AJ, Miller AP, Hatoum AS, Thompson WK, Strube M, Dick DM, Kamarajan C, Kramer JR, Plawecki MH, Chan G, Anokhin AP, Chorlian DB, Kinreich S, Meyers JL, Porjesz B, Edenberg HJ, Agrawal A, Bucholz KK, Bogdan R.) Psychol Med. 2024 Jul;54(10):2644-2657 PMID: 38721768 PMCID: PMC11464200 SCOPUS ID: 2-s2.0-85193597446 05/09/2024
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(Paul SE, Colbert SMC, Gorelik AJ, Johnson EC, Hatoum AS, Baranger DAA, Hansen IS, Nagella I, Blaydon L, Hornstein A, Elsayed NM, Barch DM, Bogdan R, Karcher NR.) Nature Mental Health. November 2024;2(11):1327-1341 SCOPUS ID: 2-s2.0-105011638715 11/01/2024