Research Group Lab Hall
David Gutterman, MD

David D. Gutterman, MD

Distinguished Professor of Cardiovascular Medicine; Senior Associate Director Emeritus, Cardiovascular Center; Program Director, CVC T32 Training Program

Contact Information

General Interests

Cardiovascular Pharmacology

Education

MD, University of North Carolina at Chapel Hill School of Medicine, 1980

Research Experience

  • Angina Pectoris
  • Coronary Artery Disease
  • Coronary Circulation
  • Endothelium
  • Endothelium, Vascular
  • Endothelium-Dependent Relaxing Factors
  • Nitric Oxide
  • Reactive Oxygen Species
  • Vasodilation

MCW Program / Core Facilities

  • Cardiovascular Center
  • Clinical and Translational Science Institute

Research Interests

Dr. Gutterman is actively involved in clinical practice, teaching, and microcirculatory research.

Dr. Gutterman's investigative interests focus on regulation of human vascular reactivity both at the fundamental and translational research levels. His work has defined a novel mechanism whereby a switch occurs in the mediator of flow-induced dilation from nitric oxide to shear-released mitochondria-derived hydrogen peroxide in the microcirculation of patients with coronary artery disease. The cellular mechanism of this switch is under active investigation with emerging roles for extranuclear telomerase, short chain ceramides, and autophagy as key modulators of mitochondrial ROS.

His research efforts span basic and clinical science related to vascular health and disease. His laboratory is one of only two worldwide that regularly examine vascular function in human resistance arteries.

Dr. Gutterman has also undertaken studies to examine the earliest changes that occur in the development of atherosclerosis (clinical endothelium dysfunction in the brachial artery and in adipose resistance arteries) and has used these techniques to examine the beneficial and detrimental roles of various exercise regimens and of dieting on cardiovascular health.

Publications

  • Reply to Boedtkjer and Aalkjaer.

    (Wenceslau CF, McCarthy CG, Earley S, England SK, Filosa JA, Goulopoulou S, Gutterman DD, Isakson BE, Kanagy NL, Martinez-Lemus LA, Sonkusare SK, Thakore P, Trask AJ, Watts SW, Webb RC.) Am J Physiol Heart Circ Physiol. 2022 04 01;322(4):H687-H688 PMID: 35324334 PMCID: PMC8957339 SCOPUS ID: 2-s2.0-85127056383 03/25/2022

  • Reply to De Mey et al.

    (Wenceslau CF, McCarthy CG, Earley S, England SK, Filosa JA, Goulopoulou S, Gutterman DD, Isakson BE, Kanagy NL, Martinez-Lemus LA, Sonkusare SK, Thakore P, Trask AJ, Watts SW, Webb RC.) Am J Physiol Heart Circ Physiol. 2022 04 01;322(4):H683-H684 PMID: 35324332 PMCID: PMC8957323 SCOPUS ID: 2-s2.0-85127034410 03/25/2022

  • Pulling back the curtain on anthracycline cardiotoxicity: the hidden role of the microcirculation.

    (Brandt L, Terwoord JD, Beyer AM, Gutterman DD.) Cardiovasc Res. 2022 01 29;118(2):347-349 PMID: 34196687 SCOPUS ID: 2-s2.0-85123969900 07/02/2021

  • Endothelial dysfunction as a complication of anti-cancer therapy.

    (Terwoord JD, Beyer AM, Gutterman DD.) Pharmacol Ther. 2022 Jan 19;237:108116 PMID: 35063569 01/23/2022

  • Prolonged endothelial-dysfunction in human arterioles following infection with SARS-CoV-2.

    (Nishijima Y, Hader SN, Hanson AJ, Zhang DX, Sparapani R, Gutterman DD, Beyer AM.) Cardiovasc Res. 2022 01 07;118(1):18-19 PMID: 34755839 PMCID: PMC8689948 SCOPUS ID: 2-s2.0-85123651313 11/11/2021

  • Change in out-of-hospital 12-lead ECG diagnostic classification following resuscitation from cardiac arrest.

    (Aufderheide TP, Engel TW 2nd, Saleh HO, Gutterman DD, Weston BW, Pepe PE, Baker JE, Labinski J, Debaty G, Tang L, Szabo A, Kalra R, Yannopoulos D, Colella MR.) Resuscitation. 2021 12;169:45-52 PMID: 34666124 SCOPUS ID: 2-s2.0-85118490179 10/20/2021

  • Vascular Dysfunction in Preeclampsia.

    (Opichka MA, Rappelt MW, Gutterman DD, Grobe JL, McIntosh JJ.) Cells. 2021 11 06;10(11) PMID: 34831277 PMCID: PMC8616535 11/28/2021

  • Guidelines for the measurement of vascular function and structure in isolated arteries and veins.

    (Wenceslau CF, McCarthy CG, Earley S, England SK, Filosa JA, Goulopoulou S, Gutterman DD, Isakson BE, Kanagy NL, Martinez-Lemus LA, Sonkusare SK, Thakore P, Trask AJ, Watts SW, Webb RC.) Am J Physiol Heart Circ Physiol. 2021 07 01;321(1):H77-H111 PMID: 33989082 PMCID: PMC8321813 SCOPUS ID: 2-s2.0-85109117850 05/15/2021

  • Hypertension preserves the magnitude of microvascular flow-mediated dilation following transient elevation in intraluminal pressure.

    (Hughes WE, Zinkevich N, Gutterman DD, Beyer AM.) Physiol Rep. 2021 02;9(3):e14507 PMID: 33587335 PMCID: PMC7883808 SCOPUS ID: 2-s2.0-85100849665 02/16/2021

  • Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.

    (Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, Abdellatif M, Abdoli A, Abel S, Abeliovich H, Abildgaard MH, Abudu YP, Acevedo-Arozena A, Adamopoulos IE, Adeli K, Adolph TE, Adornetto A, Aflaki E, Agam G, Agarwal A, Aggarwal BB, Agnello M, Agostinis P, Agrewala JN, Agrotis A, Aguilar PV, Ahmad ST, Ahmed ZM, Ahumada-Castro U, Aits S, Aizawa S, Akkoc Y, Akoumianaki T, Akpinar HA, Al-Abd AM, Al-Akra L, Al-Gharaibeh A, Alaoui-Jamali MA, Alberti S, Alcocer-Gómez E, Alessandri C, Ali M, Alim Al-Bari MA, Aliwaini S, Alizadeh J, Almacellas E, Almasan A, Alonso A, Alonso GD, Altan-Bonnet N, Altieri DC, Álvarez ÉMC, Alves S, Alves da Costa C, Alzaharna MM, Amadio M, Amantini C, Amaral C, Ambrosio S, Amer AO, Ammanathan V, An Z, Andersen SU, Andrabi SA, Andrade-Silva M, Andres AM, Angelini S, Ann D, Anozie UC, Ansari MY, Antas P, Antebi A, Antón Z, Anwar T, Apetoh L, Apostolova N, Araki T, Araki Y, Arasaki K, Araújo WL, Araya J, Arden C, Arévalo MA, Arguelles S, Arias E, Arikkath J, Arimoto H, Ariosa AR, Armstrong-James D, Arnauné-Pelloquin L, Aroca A, Arroyo DS, Arsov I, Artero R, Asaro DML, Aschner M, Ashrafizadeh M, Ashur-Fabian O, Atanasov AG, Au AK, Auberger P, Auner HW, Aurelian L, Autelli R, Avagliano L, Ávalos Y, Aveic S, Aveleira CA, Avin-Wittenberg T, Aydin Y, Ayton S, Ayyadevara S, Azzopardi M, Baba M, Backer JM, Backues SK, Bae DH, Bae ON, Bae SH, Baehrecke EH, Baek A, Baek SH, Baek SH, Bagetta G, Bagniewska-Zadworna A, Bai H, Bai J, Bai X, Bai Y, Bairagi N, Baksi S, Balbi T, Baldari CT, Balduini W, Ballabio A, Ballester M, Balazadeh S, Balzan R, Bandopadhyay R, Banerjee S, Banerjee S, Bánréti Á, Bao Y, Baptista MS, Baracca A, Barbati C, Bargiela A, Barilà D, Barlow PG, Barmada SJ, Barreiro E, Barreto GE, Bartek J, Bartel B, Bartolome A, Barve GR, Basagoudanavar SH, Bassham DC, Bast RC Jr, Basu A, Batoko H, Batten I, Baulieu EE, Baumgarner BL, Bayry J, Beale R, Beau I, Beaumatin F, Bechara LRG, Beck GR Jr, Beers MF, Begun J, Behrends C, Behrens GMN, Bei R, Bejarano E, Bel S, Behl C, Belaid A, Belgareh-Touzé N, Bellarosa C, Belleudi F, Belló Pérez M, Bello-Morales R, Beltran JSO, Beltran S, Benbrook DM, Bendorius M, Benitez BA, Benito-Cuesta I, Bensalem J, Berchtold MW, Berezowska S, Bergamaschi D, Bergami M, Bergmann A, Berliocchi L, Berlioz-Torrent C, Bernard A, Berthoux L, Besirli CG, Besteiro S, Betin VM, Beyaert R, Bezbradica JS, Bhaskar K, Bhatia-Kissova I, Bhattacharya R, Bhattacharya S, Bhattacharyya S, Bhuiyan MS, Bhutia SK, Bi L, Bi X, Biden TJ, Bijian K, Billes VA, Binart N, Bincoletto C, Birgisdottir AB, Bjorkoy G, Blanco G, Blas-Garcia A, Blasiak J, Blomgran R, Blomgren K, Blum JS, Boada-Romero E, Boban M, Boesze-Battaglia K, Boeuf P, Boland B, Bomont P, Bonaldo P, Bonam SR, Bonfili L, Bonifacino JS, Boone BA, Bootman MD, Bordi M, Borner C, Bornhauser BC, Borthakur G, Bosch J, Bose S, Botana LM, Botas J, Boulanger CM, Boulton ME, Bourdenx M, Bourgeois B, Bourke NM, Bousquet G, Boya P, Bozhkov PV, Bozi LHM, Bozkurt TO, Brackney DE, Brandts CH, Braun RJ, Braus GH, Bravo-Sagua R, Bravo-San Pedro JM, Brest P, Bringer MA, Briones-Herrera A, Broaddus VC, Brodersen P, Brodsky JL, Brody SL, Bronson PG, Bronstein JM, Brown CN, Brown RE, Brum PC, Brumell JH, Brunetti-Pierri N, Bruno D, Bryson-Richardson RJ, Bucci C, Buchrieser C, Bueno M, Buitrago-Molina LE, Buraschi S, Buch S, Buchan JR, Buckingham EM, Budak H, Budini M, Bultynck G, Burada F, Burgoyne JR, Burón MI, Bustos V, Büttner S, Butturini E, Byrd A, Cabas I, Cabrera-Benitez S, Cadwell K, Cai J, Cai L, Cai Q, Cairó M, Calbet JA, Caldwell GA, Caldwell KA, Call JA, Calvani R, Calvo AC, Calvo-Rubio Barrera M, Camara NO, Camonis JH, Camougrand N, Campanella M, Campbell EM, Campbell-Valois FX, Campello S, Campesi I, Campos JC, Camuzard O, Cancino J, Candido de Almeida D, Canesi L, Caniggia I, Canonico B, Cantí C, Cao B, Caraglia M, Caramés B, Carchman EH, Cardenal-Muñoz E, Cardenas C, Cardenas L, Cardoso SM, Carew JS, Carle GF, Carleton G, Carloni S, Carmo.) Autophagy. 2021 Jan;17(1):1-382 PMID: 33634751 PMCID: PMC7996087 SCOPUS ID: 2-s2.0-85102619204 02/27/2021

  • Critical Interaction Between Telomerase and Autophagy in Mediating Flow-Induced Human Arteriolar Vasodilation.

    (Hughes WE, Chabowski DS, Ait-Aissa K, Fetterman JL, Hockenberry J, Beyer AM, Gutterman DD.) Arterioscler Thromb Vasc Biol. 2021 01;41(1):446-457 PMID: 33232201 PMCID: PMC7770118 SCOPUS ID: 2-s2.0-85098224505 11/25/2020

  • Two weeks of remote ischemic conditioning improves brachial artery flow mediated dilation in chronic stroke survivors.

    (Hyngstrom AS, Nguyen JN, Wright MT, Tarima SS, Schmit BD, Gutterman DD, Durand MJ.) J Appl Physiol (1985). 2020 12 01;129(6):1348-1354 PMID: 33090908 PMCID: PMC7792845 SCOPUS ID: 2-s2.0-85097570561 10/23/2020