Anthony J. Trimboli, PhD

Publications

• Stromal Platelet-Derived Growth Factor Receptor-β Signaling Promotes Breast Cancer Metastasis in the Brain.

  (Thies KA, Hammer AM, Hildreth BE 3rd, Steck SA, Spehar JM, Kladney RD, Geisler JA, Das M, Russell LO, Bey JF 4th, Bolyard CM, Pilarski R, Trimboli AJ, Cuitiño MC, Koivisto CS, Stover DG, Schoenfield L, Otero J, Godbout JP, Chakravarti A, Ringel MD, Ramaswamy B, Li Z, Kaur B, Leone G, Ostrowski MC, Sizemore ST, Sizemore GM.) Cancer Res. 2021 02 01;81(3):606-618 PMID: 32327406 PMCID: PMC7581545 SCOPUS ID: 2-s2.0-85100405678 04/25/2020

• Abrupt involution induces inflammation, estrogenic signaling, and hyperplasia linking lack of breastfeeding with increased risk of breast cancer.

  (Basree MM, Shinde N, Koivisto C, Cuitino M, Kladney R, Zhang J, Stephens J, Palettas M, Zhang A, Kim HK, Acero-Bedoya S, Trimboli A, Stover DG, Ludwig T, Ganju R, Weng D, Shields P, Freudenheim J, Leone GW, Sizemore GM, Majumder S, Ramaswamy B.) Breast Cancer Res. 2019 07 17;21(1):80 PMID: 31315645 PMCID: PMC6637535 SCOPUS ID: 2-s2.0-85070057466 07/19/2019

• Stromal PTEN determines mammary epithelial response to radiotherapy.

  (Sizemore GM, Balakrishnan S, Thies KA, Hammer AM, Sizemore ST, Trimboli AJ, Cuitiño MC, Steck SA, Tozbikian G, Kladney RD, Shinde N, Das M, Park D, Majumder S, Krishnan S, Yu L, Fernandez SA, Chakravarti A, Shields PG, White JR, Yee LD, Rosol TJ, Ludwig T, Park M, Leone G, Ostrowski MC.) Nat Commun. 2018 07 17;9(1):2783 PMID: 30018330 PMCID: PMC6050339 SCOPUS ID: 2-s2.0-85050372792 07/19/2018

• Stromal PTEN inhibits the expansion of mammary epithelial stem cells through Jagged-1.

  (Sizemore GM, Balakrishnan S, Hammer AM, Thies KA, Trimboli AJ, Wallace JA, Sizemore ST, Kladney RD, Woelke SA, Yu L, Fernandez SA, Chakravarti A, Leone G, Ostrowski MC.) Oncogene. 2017 11 23;36(47):6658 PMID: 29035387 10/17/2017

• Selective roles of E2Fs for ErbB2- and Myc-mediated mammary tumorigenesis.

  (Wu L, de Bruin A, Wang H, Simmons T, Cleghorn W, Goldenberg LE, Sites E, Sandy A, Trimboli A, Fernandez SA, Eng C, Shapiro C, Leone G.) Oncogene. 2015 Jan 02;34(1):119-28 PMID: 24276244 PMCID: PMC4032808 SCOPUS ID: 2-s2.0-84964314758 11/28/2013

• Viral oncogene expression in the stem/progenitor cell compartment of the mouse intestine induces adenomatous polyps.

  (Sáenz Robles MT, Chong JL, Koivisto C, Trimboli A, Liu H, Leone G, Pipas JM.) Mol Cancer Res. 2014 Oct;12(10):1355-64 PMID: 24994749 PMCID: PMC4201981 SCOPUS ID: 2-s2.0-84907994320 07/06/2014

• Ets2 in tumor fibroblasts promotes angiogenesis in breast cancer.

  (Wallace JA, Li F, Balakrishnan S, Cantemir-Stone CZ, Pecot T, Martin C, Kladney RD, Sharma SM, Trimboli AJ, Fernandez SA, Yu L, Rosol TJ, Stromberg PC, Lesurf R, Hallett M, Park M, Leone G, Ostrowski MC.) PLoS One. 2013;8(8):e71533 PMID: 23977064 PMCID: PMC3745457 SCOPUS ID: 2-s2.0-84881561093 08/27/2013

• Evidence for a stepwise program of extrathymic T cell development within the human tonsil.

  (McClory S, Hughes T, Freud AG, Briercheck EL, Martin C, Trimboli AJ, Yu J, Zhang X, Leone G, Nuovo G, Caligiuri MA.) J Clin Invest. 2012 Apr;122(4):1403-15 PMID: 22378041 PMCID: PMC3314444 SCOPUS ID: 2-s2.0-84858793590 03/02/2012

• Reprogramming of the tumour microenvironment by stromal PTEN-regulated miR-320.

  (Bronisz A, Godlewski J, Wallace JA, Merchant AS, Nowicki MO, Mathsyaraja H, Srinivasan R, Trimboli AJ, Martin CK, Li F, Yu L, Fernandez SA, Pécot T, Rosol TJ, Cory S, Hallett M, Park M, Piper MG, Marsh CB, Yee LD, Jimenez RE, Nuovo G, Lawler SE, Chiocca EA, Leone G, Ostrowski MC.) Nat Cell Biol. 2011 Dec 18;14(2):159-67 PMID: 22179046 PMCID: PMC3271169 SCOPUS ID: 2-s2.0-84856464305 12/20/2011

• The Ras oncogene signals centrosome amplification in mammary epithelial cells through cyclin D1/Cdk4 and Nek2.

  (Zeng X, Shaikh FY, Harrison MK, Adon AM, Trimboli AJ, Carroll KA, Sharma N, Timmers C, Chodosh LA, Leone G, Saavedra HI.) Oncogene. 2010 Sep 09;29(36):5103-12 PMID: 20581865 PMCID: PMC2972189 SCOPUS ID: 2-s2.0-77956627154 06/29/2010

• Pten in stromal fibroblasts suppresses mammary epithelial tumours.

  (Trimboli AJ, Cantemir-Stone CZ, Li F, Wallace JA, Merchant A, Creasap N, Thompson JC, Caserta E, Wang H, Chong JL, Naidu S, Wei G, Sharma SM, Stephens JA, Fernandez SA, Gurcan MN, Weinstein MB, Barsky SH, Yee L, Rosol TJ, Stromberg PC, Robinson ML, Pepin F, Hallett M, Park M, Ostrowski MC, Leone G.) Nature. 2009 Oct 22;461(7267):1084-91 PMID: 19847259 PMCID: PMC2767301 SCOPUS ID: 2-s2.0-70350510924 10/23/2009