Xiaowen Bai, MD, PhD
- Cell Biology, Neurobiology & Anatomy
PhD, Stem Cell Center, Beijing University, Beijing, China, 2004
MD, Shanxi Medical University, Taiyuan, Shanxi, China, 1993
Research Area 1: Non-coding RNAs, mitochondria, and cell stress-related genes in neurodegeneration:
Neurological disorders have emerged as a predominant healthcare concern in recent years due to their severe consequences on quality of life and prevalence throughout the world. Understanding the underlying mechanisms of these diseases and the interactions between different brain cell types is essential for the development of new therapeutics. Many drugs (e.g., anesthetics), environmental factors (e.g., alcohol), diseases, and genetic risks are related to neurodegeneration. We examine the novel molecular mechanisms underlying the roles of microRNAs, long non-coding RNAs, mitochondria, immediate early and other cell stress-related genes in neurodegeneration using both mouse, and human stem cell-derived brain cell and three-dimensional mini brain models
Human induced pluripotent stem cell-derived mini brain (left) and the neurons in mini brain (middle). Alcohol-induced neuroapoptosis (red) in neonatal mouse brain (right).
Research Area 2: Stem cell-mediated myocardial regeneration
Myocardial infarction is one of the major causes of death throughout the world. Currently, there is not a highly effective approach for treatment. Stem cells hold promise in repairing injured cardiac tissue. Our lab is involved in studying the effect of the transplantation of adipose tissue-derived stem cells and induced pluripotent stem cell-derived cardiomyocytes on myocardial regeneration following ischemia injury. A molecular imaging method has been developed to investigate the molecular mechanisms controlling homing, engraftment, and survival of injected cells in vivo.
Research Area 3: The mechanisms of impaired cardioprotection under diabetic conditions
Hyperglycemia has been shown to be particularly detrimental to the cardioprotective effects, with the underlying mechanisms remaining largely unknown. We have developed and validated a clinically relevant model of functional human cardiomyocytes derived from both normal induced pluripotent stem cells (iPSCs) and diabetes mellitus iPSCs. This in vitro model of human disease will enable developmental and comparative studies of normal and diabetic cardiomyocytes to address genetic and environmental mechanisms responsible for attenuation of cardioprotection signaling in diabetics.
Functional contracting human cardiomyocytes generated from induced pluripotent stem cells
Mitochondrial dynamics (movement, fusion and fission) in human neurons generated from embryonic stem cells. Green signals represent mitochondria. Red and yellow colors highlight mitochondria in process of fusion.
(Arzua T, Yan Y, Jiang C, Logan S, Allison RL, Wells C, Kumar SN, Schäfer R, Bai X.) Transl Psychiatry. 2020 Oct 13;10(1):347 PMID: 33051447 PMCID: PMC7553959 SCOPUS ID: 2-s2.0-85092448660 10/15/2020
(Emelyanova L, Bai X, Yan Y, Bosnjak ZJ, Kress D, Warner C, Kroboth S, Rudic T, Kaushik S, Stoeckl E, Ross GR, Rizvi F, Tajik AJ, Jahangir A.) Transl Res. 2020 Oct 10 PMID: 33045408 SCOPUS ID: 2-s2.0-85095776755 10/13/2020
(Yan Y, Arzua T, Logan S, Bai X.) Methods Mol Biol. 2020 Oct 08 PMID: 33029748 10/09/2020
(Bai X.) Cells. 2020 09 29;9(10) PMID: 33003295 PMCID: PMC7599677 SCOPUS ID: 2-s2.0-85092490838 10/03/2020
Dynamic Characterization of Structural, Molecular, and Electrophysiological Phenotypes of Human-Induced Pluripotent Stem Cell-Derived Cerebral Organoids, and Comparison with Fetal and Adult Gene Profiles.
(Logan S, Arzua T, Yan Y, Jiang C, Liu X, Yu LK, Liu QS, Bai X.) Cells. 2020 05 23;9(5) PMID: 32456176 PMCID: PMC7291286 SCOPUS ID: 2-s2.0-85085461803 05/28/2020
(Niu X, Zhao Y, Yang N, Zhao X, Zhang W, Bai X, Li A, Yang W, Lu L.) Stem Cells. 2020 02;38(2):246-260 PMID: 31648402 SCOPUS ID: 2-s2.0-85075204508 10/28/2019
(Alt EU, Schmitz C, Bai X.) Bioethics and Research on Adult Stem Cells. 2020; 01 01/01/2020
(Pant T, Dhanasekaran A, Bai X, Zhao M, Thorp EB, Forbess JM, Bosnjak ZJ, Ge ZD.) Sci Rep. 2019 10 25;9(1):15345 PMID: 31653946 PMCID: PMC6814824 SCOPUS ID: 2-s2.0-85074150710 10/28/2019
(Horikoshi Y, Yan Y, Terashvili M, Wells C, Horikoshi H, Fujita S, Bosnjak ZJ, Bai X.) Cells. 2019 09 17;8(9) PMID: 31533262 PMCID: PMC6769886 SCOPUS ID: 2-s2.0-85080144549 09/20/2019
(Logan S, Arzua T, Canfield SG, Seminary ER, Sison SL, Ebert AD, Bai X.) Compr Physiol. 2019 03 14;9(2):565-611 PMID: 30873582 PMCID: PMC6705133 SCOPUS ID: 2-s2.0-85062970410 03/16/2019
(Pant T, Mishra MK, Bai X, Ge ZD, Bosnjak ZJ, Dhanasekaran A.) Diab Vasc Dis Res. 2019 01;16(1):57-68 PMID: 30482051 SCOPUS ID: 2-s2.0-85058938678 11/30/2018
(Pant T, Dhanasekaran A, Fang J, Bai X, Bosnjak ZJ, Liang M, Ge ZD.) BMC Cardiovasc Disord. 2018 10 20;18(1):197 PMID: 30342478 PMCID: PMC6196023 SCOPUS ID: 2-s2.0-85055075405 10/22/2018