Dr. Volkman obtained his Bachelor of Science degree in Chemistry and Physics from Butler University in 1989 and his Doctorate degree from The University of California at Berkeley. The latter was awarded in 1994 for structural studies on proteins involved in bacterial gene regulation using NMR spectroscopy. Dr. Volkman's postdoctoral training was in the Department of Biochemistry at the University of Wisconsin-Madison. In 2000, Dr. Volkman started at the Medical College of Wisconsin where he is Professor in the Biochemistry Department. Dr. Volkman's work focuses on the structural biology of immunological signaling molecules and the use of NMR spectroscopy in structural proteomics.
- Amino Acid Sequence
- Binding Sites
- Chemokine CCL21
- Chemokine CXCL12
- Chemokines, C
- Chemokines, CXC
- Computational Biology
- Crystallography, X-Ray
- Drug Design
Our goal is to invent new ways to treat cancer and other ailments by examining the three-dimensional architecture of proteins involved in disease and synthesizing new drug candidate molecules. This research links the expertise of chemists, structural biologists, and clinician-scientists who collaborate in the design and testing of potential therapies. Graduate students in my group have invented and patented new compounds that show promise as treatments for cancer and psoriasis. Your donation helps us accelerate the drug development process by paying for preclinical studies that most research grants simply won’t support - bridging the gap between our basic science discoveries and clinical trials.
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We use NMR spectroscopy and many other techniques to (1) understand the transmission of biological signals in terms of molecular structure, recognition and dynamics and (2) exploit this knowledge for the design and discovery of new molecules with practical utility as research tools, bioactive nanomaterials, or new drugs.
Dynamics and folding. Protein function is exquisitely dependent on compactly folded structures that combine energetic stability with intrinsic flexibility. Our work has revealed surprising new examples of conformational variability and altered the established paradigm for protein folding to include the new category of ‘metamorphic’ proteins. We are now trying to define the thermodynamic and evolutionary origins of metamorphic folding using the divergence of human lymphotactin from the rest of the chemokine family as a prototypical example. Other projects analyze novel modes of conformational switching that control cell polarity and enzyme activity.
Molecular recognition. Biological signals are often controlled by promoting or disrupting the interaction between two proteins. Many chemokines have been directly implicated in human diseases. Compounds that block chemokine signaling might function as inhibitors of inflammation, cancer progression, viral infection or autoimmune disease. We recently used NMR to solve the structure of the first chemokine-receptor complex, and subsequently used the details of this interface to search for small molecule ligands that bind the chemokine and block its activity. A hybrid in silico/NMR approach to inhibitor screening is now being used to target multiple chemokines with the ultimate goal of drug discovery to treat metastatic cancer and psoriasis.
Back Row L. to R.: Chris Veldkamp, Francis Peterson, Rob Tyler, Anthony Getschman (hands), Austin Jiang,
Alex Chadwick, Davin Jensen, Dustin Whitney and Josh Weiner
Middle Row L. to R.: Chad Koplinski, Amanda Nevins
First Row L. to R.: Dr. Brian Volkman, Echo the dog, Jamie Wieting, Becky Holme
(Gao X, Enten GA, DeSantis AJ, Volkman BF, Gaponenko V, Majetschak M.) Biochem Biophys Res Commun. 2020 Jul 23;528(2):368-375 PMID: 32085899 SCOPUS ID: 2-s2.0-85079757912 02/23/2020
(Wedemeyer MJ, Mueller BK, Bender BJ, Meiler J, Volkman BF.) Biochem Biophys Res Commun. 2020 Jul 23;528(2):389-397 PMID: 31924303 PMCID: PMC7295663 SCOPUS ID: 2-s2.0-85077616577 01/12/2020
(Dishman AF, Lee MW, de Anda J, Lee EY, He J, Huppler AR, Wong GCL, Volkman BF.) ACS Infect Dis. 2020 May 08;6(5):1204-1213 PMID: 32243126 PMCID: PMC7258946 SCOPUS ID: 2-s2.0-85084720920 04/04/2020
(Moussouras NA, Hjortø GM, Peterson FC, Szpakowska M, Chevigné A, Rosenkilde MM, Volkman BF, Dwinell MB.) Biochemistry. 2020 Apr 07;59(13):1338-1350 PMID: 32182428 PMCID: PMC7307649 SCOPUS ID: 2-s2.0-85083041593 03/18/2020
(Lau S, Feitzinger A, Venkiteswaran G, Wang J, Lewellis SW, Koplinski CA, Peterson FC, Volkman BF, Meier-Schellersheim M, Knaut H.) Nat Cell Biol. 2020 03;22(3):266-273 PMID: 32042179 SCOPUS ID: 2-s2.0-85079456516 02/12/2020
(Elmansi AM, Hussein KA, Herrero SM, Periyasamy-Thandavan S, Aguilar-Pérez A, Kondrikova G, Kondrikov D, Eisa NH, Pierce JL, Kaiser H, Ding KH, Walker AL, Jiang X, Bollag WB, Elsalanty M, Zhong Q, Shi Xm, Su Y, Johnson M, Hunter M, Reitman C, Volkman BF, Hamrick MW, Isales CM, Fulzele S, McGee-Lawrence ME, Hill WD.) Bone Reports. June 2020;12 SCOPUS ID: 2-s2.0-85084158144 06/01/2020
(Wedemeyer MJ, Mueller BK, Bender BJ, Meiler J, Volkman BF.) Biochemical and Biophysical Research Communications. 2020 SCOPUS ID: 2-s2.0-85077616577 01/01/2020
(Vaidya AS, Helander JDM, Peterson FC, Elzinga D, Dejonghe W, Kaundal A, Park SY, Xing Z, Mega R, Takeuchi J, Khanderahoo B, Bishay S, Volkman BF, Todoroki Y, Okamoto M, Cutler SR.) Science. 2019 10 25;366(6464) PMID: 31649167 SCOPUS ID: 2-s2.0-85074062657 10/28/2019
(Fox JC, Thomas MA, Dishman AF, Larsen O, Nakayama T, Yoshie O, Rosenkilde MM, Volkman BF.) Sci Signal. 2019 09 03;12(597) PMID: 31481523 PMCID: PMC6733756 SCOPUS ID: 2-s2.0-85071750983 09/05/2019
What doesn't kill you makes you stranger: Dipeptidyl peptidase-4 (CD26) proteolysis differentially modulates the activity of many peptide hormones and cytokines generating novel cryptic bioactive ligands.
(Elmansi AM, Awad ME, Eisa NH, Kondrikov D, Hussein KA, Aguilar-Pérez A, Herberg S, Periyasamy-Thandavan S, Fulzele S, Hamrick MW, McGee-Lawrence ME, Isales CM, Volkman BF, Hill WD.) Pharmacol Ther. 2019 06;198:90-108 PMID: 30759373 SCOPUS ID: 2-s2.0-85062148942 02/14/2019
(Kleist AB, Peterson F, Tyler RC, Gustavsson M, Handel TM, Volkman BF.) Methods Cell Biol. 2019;149:259-288 PMID: 30616824 PMCID: PMC6941889 SCOPUS ID: 2-s2.0-85056642454 01/09/2019
(Wedemeyer MJ, Mueller BK, Bender BJ, Meiler J, Volkman BF.) Methods Cell Biol. 2019;149:289-314 PMID: 30616825 PMCID: PMC6790067 SCOPUS ID: 2-s2.0-85055739819 01/09/2019