Brian Smith, PhD
Assistant Professor
Locations
- Biochemistry
BSB 356
Contact Information
Education
BS, University of Illinois at Urbana-Champaign, 2003
Biography
Dr. Smith received his Bachelor of Science in Chemistry from the University of Illinois at Urbana-Champaign in 2003. He then received his PhD in Chemistry from the University of Wisconsin-Madison in 2008, where his research focused on the chemical mechanisms of sirtuin protein lysine deacetylases. During his graduate career he spent a brief period at Genentech in the Department of Medicinal Chemistry where he synthesized drugs that target the Inhibitor of Apoptosis family of proteins. From 2009-2014, Dr. Smith performed postdoctoral studies on nitric oxide synthases and cysteine S-nitrosation at the University of California, Berkeley and the Scripps Research Institute in La Jolla. During his postdoctoral studies Dr. Smith was awarded an NIH Ruth L. Kirschstein National Research Service Award. Dr. Smith joined the faculty at the Medical College of Wisconsin in 2014.
Research Experience
- Alkylating Agents
- Amino Acids, Peptides, and Proteins
- Binding Sites
- Biochemistry
- Catalysis
- Deuterium Exchange Measurement
- Enzyme Activators
- Enzyme Inhibitors
- Enzymes and Coenzymes
- Histone Code
- Histone Deacetylases
- Mass Spectrometry
Methodologies and Techniques
- Biochemistry
- Biological Assay
- chemical synthesis
- Chromatography, Affinity
- Electrophoresis
- enzymology
- Mass Spectrometry
- Models, Chemical
- Models, Molecular
- Mutagenesis
- Nuclear Magnetic Resonance, Biomolecular
- Peptide Library
MCW Program / Core Facilities
- Biochemistry
- Redox Biology
Publications
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(Kalous KS, Wynia-Smith SL, Summers SB, Smith BC.) J Biol Chem. 2020 Jun 19;295(25):8524-8536 PMID: 32371394 PMCID: PMC7307208 05/07/2020
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(Olp MD, Kalous KS, Smith BC.) BMC Bioinformatics. 2020 May 14;21(1):186 PMID: 32410570 PMCID: PMC7222511 05/16/2020
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Validation and Characterization of Five Distinct Novel Inhibitors of Human Cytomegalovirus.
(Kapoor A, Ghosh AK, Forman M, Hu X, Ye W, Southall N, Marugan J, Keyes RF, Smith BC, Meyers DJ, Ferrer M, Arav-Boger R.) J Med Chem. 2020 04 23;63(8):3896-3907 PMID: 32191456 PMCID: PMC7386824 SCOPUS ID: 2-s2.0-85084027851 03/20/2020
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(Olp MD, Sprague DJ, Goetz CJ, Kathman SG, Wynia-Smith SL, Shishodia S, Summers SB, Xu Z, Statsyuk AV, Smith BC.) ACS Chem Biol. 2020 04 17;15(4):1036-1049 PMID: 32149490 PMCID: PMC7271629 03/10/2020
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Mitochondrial Metabolic Reprogramming by CD36 Signaling Drives Macrophage Inflammatory Responses.
(Chen Y, Yang M, Huang W, Chen W, Zhao Y, Schulte ML, Volberding P, Gerbec Z, Zimmermann MT, Zeighami A, Demos W, Zhang J, Knaack DA, Smith BC, Cui W, Malarkannan S, Sodhi K, Shapiro JI, Xie Z, Sahoo D, Silverstein RL.) Circ Res. 2019 12 06;125(12):1087-1102 PMID: 31625810 PMCID: PMC6921463 SCOPUS ID: 2-s2.0-85076330129 10/19/2019
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(McCusker P, Mian MY, Li G, Olp MD, Tiruveedhula VVNPB, Rashid F, Golani LK, Verma RS, Smith BC, Cook JM, Chan JD.) PLoS Negl Trop Dis. 2019 11;13(11):e0007826 PMID: 31730614 PMCID: PMC6881066 11/16/2019
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(Bruegger JJ, Smith BC, Wynia-Smith SL, Marletta MA.) J Biol Chem. 2018 04 27;293(17):6282-6296 PMID: 29483187 PMCID: PMC5925818 02/28/2018
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(Fahey JM, Stancill JS, Smith BC, Girotti AW.) J Biol Chem. 2018 04 06;293(14):5345-5359 PMID: 29440272 PMCID: PMC5892570 SCOPUS ID: 2-s2.0-85045064956 02/15/2018
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(Hanson QM, Carley JR, Gilbreath TJ, Smith BC, Underbakke ES.) J Mol Biol. 2018 03 30;430(7):935-947 PMID: 29458127 02/20/2018
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(Egner JM, Jensen DR, Olp MD, Kennedy NW, Volkman BF, Peterson FC, Smith BC, Hill RB.) Chembiochem. 2018 03 02;19(5):448-458 PMID: 29239081 PMCID: PMC5844354 SCOPUS ID: 2-s2.0-85041064927 12/15/2017
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(Olp MD, Zhu N, Smith BC.) Biochemistry. 2017 10 17;56(41):5485-5495 PMID: 28945351 PMCID: PMC5970795 09/26/2017
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Mechanism of Sirt1 NAD+-dependent Protein Deacetylase Inhibition by Cysteine S-Nitrosation.
(Kalous KS, Wynia-Smith SL, Olp MD, Smith BC.) J Biol Chem. 2016 Dec 02;291(49):25398-25410 PMID: 27756843 PMCID: PMC5207242 10/21/2016