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Brian Smith, PhD
Brian Smith, PhD

Brian Smith, PhD

Associate Director, Program in Chemical Biology; Associate Professor, Biochemistry

Locations

  • Biochemistry
    BSB 356

Contact Information

Education

PhD, University of Wisconsin - Madison, 2008
BS, University of Illinois at Urbana-Champaign, 2003
Please see the Smith lab website for more information

Biography

Dr. Smith received his Bachelor of Science in Chemistry from the University of Illinois at Urbana-Champaign in 2003. He then received his PhD in Chemistry from the University of Wisconsin-Madison in 2008, where his research focused on the chemical mechanisms of sirtuin protein lysine deacetylases. During his graduate career he spent a brief period at Genentech in the Department of Medicinal Chemistry where he synthesized drugs that target the Inhibitor of Apoptosis family of proteins. From 2009-2014, Dr. Smith performed postdoctoral studies on nitric oxide synthases and cysteine S-nitrosation at the University of California, Berkeley and the Scripps Research Institute in La Jolla. During his postdoctoral studies Dr. Smith was awarded an NIH Ruth L. Kirschstein National Research Service Award. Dr. Smith joined the faculty at the Medical College of Wisconsin in 2014.

Research Experience

  • Amino Acids, Peptides, and Proteins
  • Binding Sites
  • Biochemistry
  • Catalysis
  • Deuterium Exchange Measurement
  • Enzyme Activators
  • Enzyme Inhibitors
  • Enzymes and Coenzymes
  • Histone Code
  • Histone Deacetylases
  • Mass Spectrometry
  • Molecular Probes

Methodologies and Techniques

  • Biochemistry
  • Biological Assay
  • chemical synthesis
  • Chromatography, Affinity
  • Electrophoresis
  • enzymology
  • Mass Spectrometry
  • Models, Chemical
  • Models, Molecular
  • Mutagenesis
  • Nuclear Magnetic Resonance, Biomolecular
  • Peptide Library

Leadership Positions

  • Associate Director, Program in Chemical Biology
  • Associate Director, Structural Genomics Unit, Mellowes Center for Genomic Sciences and Precision Medicine

MCW Program / Core Facilities

  • Biochemistry
  • Redox Biology

Publications

Publications of Brian C. Smith PhD from the Faculty Collaboration Database

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