Brian Smith, PhD
Assistant Professor
Locations
- Biochemistry
BSB 356
Contact Information
Education
BS, University of Illinois at Urbana-Champaign, 2003
Biography
Dr. Smith received his Bachelor of Science in Chemistry from the University of Illinois at Urbana-Champaign in 2003. He then received his PhD in Chemistry from the University of Wisconsin-Madison in 2008, where his research focused on the chemical mechanisms of sirtuin protein lysine deacetylases. During his graduate career he spent a brief period at Genentech in the Department of Medicinal Chemistry where he synthesized drugs that target the Inhibitor of Apoptosis family of proteins. From 2009-2014, Dr. Smith performed postdoctoral studies on nitric oxide synthases and cysteine S-nitrosation at the University of California, Berkeley and the Scripps Research Institute in La Jolla. During his postdoctoral studies Dr. Smith was awarded an NIH Ruth L. Kirschstein National Research Service Award. Dr. Smith joined the faculty at the Medical College of Wisconsin in 2014.
Please see the Smith lab website for more information.
Research Experience
- Alkylating Agents
- Amino Acids, Peptides, and Proteins
- Binding Sites
- Biochemistry
- Catalysis
- Deuterium Exchange Measurement
- Enzyme Activators
- Enzyme Inhibitors
- Enzymes and Coenzymes
- Histone Code
- Histone Deacetylases
- Mass Spectrometry
Methodologies and Techniques
- Biochemistry
- Biological Assay
- chemical synthesis
- Chromatography, Affinity
- Electrophoresis
- enzymology
- Mass Spectrometry
- Models, Chemical
- Models, Molecular
- Mutagenesis
- Nuclear Magnetic Resonance, Biomolecular
- Peptide Library
MCW Program / Core Facilities
- Biochemistry
- Redox Biology
Publications
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Mitochondrial Metabolic Reprogramming by CD36 Signaling Drives Macrophage Inflammatory Responses.
(Chen Y, Yang M, Huang W, Chen W, Zhao Y, Schulte ML, Volberding P, Gerbec Z, Zimmermann MT, Zeighami A, Demos W, Zhang J, Knaack DA, Smith BC, Cui W, Malarkannan S, Sodhi K, Shapiro JI, Xie Z, Sahoo D, Silverstein RL.) Circ Res. 2019 Dec 06;125(12):1087-1102.
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(McCusker P, Mian MY, Li G, Olp MD, Tiruveedhula VVNPB, Rashid F, Golani LK, Verma RS, Smith BC, Cook JM, Chan JD.) PLoS Negl Trop Dis. 2019 Nov;13(11):e0007826.
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(Bruegger JJ, Smith BC, Wynia-Smith SL, Marletta MA.) J Biol Chem. 2018 04 27;293(17):6282-6296.
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(Fahey JM, Stancill JS, Smith BC, Girotti AW.) J Biol Chem. 2018 04 06;293(14):5345-5359.
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(Hanson QM, Carley JR, Gilbreath TJ, Smith BC, Underbakke ES.) J Mol Biol. 2018 03 30;430(7):935-947.
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(Egner JM, Jensen DR, Olp MD, Kennedy NW, Volkman BF, Peterson FC, Smith BC, Hill RB.) Chembiochem. 2018 03 02;19(5):448-458.
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(Olp MD, Zhu N, Smith BC.) Biochemistry. 2017 10 17;56(41):5485-5495.
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Nitrosothiol formation and S-nitrosation signaling through nitric oxide synthases.
(Wynia-Smith SL, Smith BC.) Nitric Oxide. 2017 Feb 28;63:52-60.
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Mechanism of Sirt1 NAD+-dependent Protein Deacetylase Inhibition by Cysteine S-Nitrosation.
(Kalous KS, Wynia-Smith SL, Olp MD, Smith BC.) J Biol Chem. 2016 Dec 02;291(49):25398-25410.
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(Zhou Y, Wynia-Smith SL, Couvertier SM, Kalous KS, Marletta MA, Smith BC, Weerapana E.) Cell Chem Biol. 2016 06 23;23(6):727-37.
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(Shteyer E, Smith B.) Gastroenterology. 2015 Jul;149(1):261-2.
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Nitric Oxide Mediates Biofilm Formation and Symbiosis in Silicibacter sp. Strain TrichCH4B.
(Rao M, Smith BC, Marletta MA.) MBio. 2015 May 05;6(3):e00206-15.