
David D. Gutterman, MD
Distinguished Professor of Cardiovascular Medicine; Senior Associate Director Emeritus, Cardiovascular Center; Program Director, CVC T32 Training Program
Contact Information
General Interests
Education
Research Experience
- Angina Pectoris
- Coronary Artery Disease
- Coronary Circulation
- Endothelium
- Endothelium, Vascular
- Endothelium-Dependent Relaxing Factors
- Nitric Oxide
- Reactive Oxygen Species
- Vasodilation
MCW Program / Core Facilities
- Cardiovascular Center
- Clinical and Translational Science Institute
Research Interests
Dr. Gutterman's investigative interests focus on regulation of human vascular reactivity both at the fundamental and translational research levels. His work has defined a novel mechanism whereby a switch occurs in the mediator of flow-induced dilation from nitric oxide to shear-released mitochondria-derived hydrogen peroxide in the microcirculation of patients with coronary artery disease. The cellular mechanism of this switch is under active investigation with emerging roles for extranuclear telomerase, short chain ceramides, and autophagy as key modulators of mitochondrial ROS.
His research efforts span basic and clinical science related to vascular health and disease. His laboratory is one of only two worldwide that regularly examine vascular function in human resistance arteries.
Dr. Gutterman has also undertaken studies to examine the earliest changes that occur in the development of atherosclerosis (clinical endothelium dysfunction in the brachial artery and in adipose resistance arteries) and has used these techniques to examine the beneficial and detrimental roles of various exercise regimens and of dieting on cardiovascular health.
Publications
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(Grosman-Rimon L, Wright E, Freedman D, Kachel E, Hui S, Epstein I, Gutterman D, Eilat-Adar S.) Am J Physiol Heart Circ Physiol. 2019 09 01;317(3):H487-H495 PMID: 31322425 07/20/2019
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(Anker SD, Borggrefe M, Neuser H, Ohlow MA, Röger S, Goette A, Remppis BA, Kuck KH, Najarian KB, Gutterman DD, Rousso B, Burkhoff D, Hasenfuss G.) Eur J Heart Fail. 2019 09;21(9):1103-1113 PMID: 30652394 01/18/2019
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Visualization and quantification of mitochondrial structure in the endothelium of intact arteries.
(Durand MJ, Ait-Aissa K, Levchenko V, Staruschenko A, Gutterman DD, Beyer AM.) Cardiovasc Res. 2019 08 01;115(10):1546-1556 PMID: 30476208 PMCID: PMC6648341 SCOPUS ID: 2-s2.0-85072658081 11/27/2018
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(Mahmoud AM, Hwang CL, Szczurek MR, Bian JT, Ranieri C, Gutterman DD, Phillips SA.) Nutrients. 2019 Jun 14;11(6) PMID: 31207908 PMCID: PMC6627594 06/19/2019
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(Ait-Aissa K, Blaszak SC, Beutner G, Tsaih SW, Morgan G, Santos JH, Flister MJ, Joyce DL, Camara AKS, Gutterman DD, Donato AJ, Porter GA Jr, Beyer AM.) Sci Rep. 2019 05 20;9(1):7623 PMID: 31110224 PMCID: PMC6527853 SCOPUS ID: 2-s2.0-85066048228 05/22/2019
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(Durand MJ, Boerger TF, Nguyen JN, Alqahtani SZ, Wright MT, Schmit BD, Gutterman DD, Hyngstrom AS.) J Appl Physiol (1985). 2019 03 01;126(3):755-763 PMID: 30653420 PMCID: PMC6459385 01/18/2019
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(Chabowski DS, Kadlec AO, Ait-Aissa K, Hockenberry JC, Pearson PJ, Beyer AM, Gutterman DD.) Br J Pharmacol. 2018 11;175(22):4266-4280 PMID: 30153326 PMCID: PMC6193883 SCOPUS ID: 2-s2.0-85054757437 08/29/2018
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(Abraham WT, Kuck KH, Goldsmith RL, Lindenfeld J, Reddy VY, Carson PE, Mann DL, Saville B, Parise H, Chan R, Wiegn P, Hastings JL, Kaplan AJ, Edelmann F, Luthje L, Kahwash R, Tomassoni GF, Gutterman DD, Stagg A, Burkhoff D, Hasenfuß G.) JACC Heart Fail. 2018 10;6(10):874-883 PMID: 29754812 05/15/2018
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(Allaqaband H, Gutterman DD, Kadlec AO.) Physiology (Bethesda). 2018 09 01;33(5):338-347 PMID: 30109826 PMCID: PMC6230549 08/16/2018
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(Hyngstrom AS, Murphy SA, Nguyen J, Schmit BD, Negro F, Gutterman DD, Durand MJ.) J Appl Physiol (1985). 2018 05 01;124(5):1140-1147 PMID: 29420152 PMCID: PMC6050199 02/09/2018
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(Ait-Aissa K, Kadlec AO, Hockenberry J, Gutterman DD, Beyer AM.) Am J Physiol Heart Circ Physiol. 2018 05 01;314(5):H1053-H1060 PMID: 29351466 PMCID: PMC6008150 SCOPUS ID: 2-s2.0-85046904084 01/20/2018
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(Das EK, Lai PY, Robinson AT, Pleuss J, Ali MM, Haus JM, Gutterman DD, Phillips SA.) Front Physiol. 2018;9:183 PMID: 29568273 PMCID: PMC5853082 03/24/2018