Evgenii Chulkov, PhD
MS, Applied Math and Physics, St. Petersburg State Polytechnic University, St. Petersburg, Russia, 2012
BS, Technical Physics, St. Petersburg State Polytechnic University, St. Petersburg, Russia, 2010
Ion channels regulation, membrane active drugs, anthelminthic drug development
Ion channels are important drug targets because of their crucial role in controlling a variety of physiological processes. Clarification of the basic molecular mechanisms underlying physiological process associated with ion channel activity in cells will aid drug development.
The Marchant Lab recently identified a target of the anthelmintic drug praziquantel used for treatment of schistosomiasis, a major parasitic disease caused by Schistosoma sp., The target protein is an ion channel of the TRP family expressed in Schistosoma sp. Currently, I am working on the molecular mechanism of channel–drug interaction via electrophysiology and imaging. In the future, I intent to create a comprehensive model of the channel to aid antiparasitic drug development.