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Guadalupe Valdivia Esparza

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Guadalupe Valdivia Esparza

Guadalupe Valdivia Esparza

G1 Student

Faculty Advisor

Daisy Sahoo, PhD, Biochemistry

Locations

Medical Scientist Training Program

Contact Information

gvaldivia@mcw.edu

Education

BS, Biomedical Sciences, Marquette University, 2020

Research Interests

Biochemistry and structural biology

Research Experience

Medical College of Wisconsin, 2023-Present
Advisor: Daisy Sahoo, PhD
Project: Structural and functional analysis of scavenger receptor class B type 1 (SR-B1)

Medical College of Wisconsin, 2018-2021
Advisor: Brian Smith, PhD
Projects: 1. Identification of selective inhibitors of Hydrogen Sulfide (H2S)-producing bacterial enzymes responsible for the formation of brain abscesses and vasoplegia. 2. Analysis of chemical probes through biophysical assays to study the role of the Survival Motor Neuron (SMN) protein in Spinal Muscular Atrophy (SMA). 3. Biophysical analysis of selective small molecules that bind PBRM1 bromodomains to identify therapeutic targets for clear cell renal cell carcinoma (ccRCC). 4. Optimization of production and purification of recombinant proteins including KRAS mutants to study their roles in cancer and rare genetic conditions.

Meeting Abstracts

Valdivia Esparza GK, Sprague D, Goetz C, Kalous K, Willoughby R, Smith B. Selectivity of inhibitors for Neisseria meningitidis cystathionine gamma-lyase (CSE). Summer Programs Symposium Medical College of Wisconsin. Milwaukee, WI. August 2018.

Valdivia Esparza GK, Sprague D, Goetz C, Kalous K, Willoughby R, Smith B. Inhibition of H2S-producing bacterial cystathionine gamma-lyase (CSE) and cystathionine beta-synthase (CBS). Summer Programs Symposium Medical College of Wisconsin. Milwaukee, WI. August 2019.

General Interests

I love exploring new places, going on nature walks, trying new things, and spending time with my nephews. I enjoy reading, listening to podcasts, and watching youtube videos. I am also big on social activism and creating inclusive and welcoming spaces for everyone.