Herve Falet, PhD

Publications

• Anti-platelet properties of Pim kinase inhibition is mediated through disruption of thromboxane A2 receptor signalling.

  (Unsworth AJ, Bye AP, Sage T, Gaspar RS, Eaton N, Drew C, Stainer A, Kriek N, Volberding PJ, Hutchinson JL, Riley R, Jones S, Mundell SJ, Cui W, Falet H, Gibbins JM.) Haematologica. 2020 May 28 PMID: 32467143 05/30/2020

• Dynamin 2 is required for GPVI signaling and platelet hemostatic function in mice.

  (Eaton N, Drew C, Wieser J, Munday AD, Falet H.) Haematologica. 2020 May;105(5):1414-1423 PMID: 31296575 PMCID: PMC7193499 07/13/2019

• β4GALT1 controls β1 integrin function to govern thrombopoiesis and hematopoietic stem cell homeostasis.

  (Giannini S, Lee-Sundlov MM, Rivadeneyra L, Di Buduo CA, Burns R, Lau JT, Falet H, Balduini A, Hoffmeister KM.) Nat Commun. 2020 01 17;11(1):356 PMID: 31953383 PMCID: PMC6968998 01/19/2020

• Decreased thromboembolic stroke but not atherosclerosis or vascular remodelling in mice with ROCK2-deficient platelets.

  (Sladojevic N, Oh GT, Kim HH, Beaulieu LM, Falet H, Kaminski K, Freedman JE, Liao JK.) Cardiovasc Res. 2017 Sep 01;113(11):1307-1317 PMID: 28430966 PMCID: PMC5852540 04/22/2017

• Singling out FLI1 in Paris-Trousseau syndrome.

  (Falet H.) Blood. 2017 06 29;129(26):3399-3401 PMID: 28663223 PMCID: PMC5492094 07/01/2017

• Glycans and the platelet life cycle.

  (Li R, Hoffmeister KM, Falet H.) Platelets. 2016 Sep;27(6):505-11 PMID: 27135356 PMCID: PMC5396182 05/03/2016

• Intracellular Trafficking, Localization, and Mobilization of Platelet-Borne Thiol Isomerases.

  (Crescente M, Pluthero FG, Li L, Lo RW, Walsh TG, Schenk MP, Holbrook LM, Louriero S, Ali MS, Vaiyapuri S, Falet H, Jones IM, Poole AW, Kahr WH, Gibbins JM.) Arterioscler Thromb Vasc Biol. 2016 06;36(6):1164-73 PMID: 27079884 PMCID: PMC5407363 04/16/2016

• Platelet clearance by the hepatic Ashwell-Morrell receptor: mechanisms and biological significance.

  (Hoffmeister KM, Falet H.) Thromb Res. 2016 May;141 Suppl 2:S68-72 PMID: 27207430 PMCID: PMC5399515 05/22/2016

• Regulating billions of blood platelets: glycans and beyond.

  (Grozovsky R, Giannini S, Falet H, Hoffmeister KM.) Blood. 2015 Oct 15;126(16):1877-84 PMID: 26330242 PMCID: PMC4608239 09/04/2015

• Novel mechanisms of platelet clearance and thrombopoietin regulation.

  (Grozovsky R, Giannini S, Falet H, Hoffmeister KM.) Curr Opin Hematol. 2015 Sep;22(5):445-51 PMID: 26154508 PMCID: PMC5326579 07/15/2015

• FlnA binding to PACSIN2 F-BAR domain regulates membrane tubulation in megakaryocytes and platelets.

  (Begonja AJ, Pluthero FG, Suphamungmee W, Giannini S, Christensen H, Leung R, Lo RW, Nakamura F, Lehman W, Plomann M, Hoffmeister KM, Kahr WH, Hartwig JH, Falet H.) Blood. 2015 Jul 02;126(1):80-8 PMID: 25838348 PMCID: PMC4492198 04/04/2015

• Corrigendum: Megakaryocyte-specific Profilin1-deficiency alters microtubule stability and causes a Wiskott-Aldrich syndrome-like platelet defect.

  (Bender M, Stritt S, Nurden P, van Eeuwijk JM, Zieger B, Kentouche K, Schulze H, Morbach H, Stegner D, Heinze KG, Dütting S, Gupta S, Witke W, Falet H, Fischer A, Hartwig JH, Nieswandt B.) Nat Commun. 2015 Mar 06;6:6507 PMID: 25744693 PMCID: PMC4400601 03/07/2015