
Joseph T. Barbieri, PhD
Professor; Director, Medical Scientist Training Program
Locations
- Microbiology & Immunology
BSB B2830
Contact Information
General Interests
Education
Research Interests
My laboratory studies the molecular basis of microbial pathogenesis in Cellular Microbiology where components of the pathogen and host are analyzed to understand the pathogenic process. My research involves the study of bacterial toxins. Several families of bacterial toxins are under investigation: botulinum and tetanus neurotoxins; Certhrax, an ADP-ribosylating exotoxin from Bacillus cereus; and ExoS, a type III cytotoxin of Pseudomonas aeruginosa.
Publications
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A Novel High-Potency Tetanus Vaccine.
(Przedpelski A, Tepp WH, Pellett S, Johnson EA, Barbieri JT.) mBio. 2020 08 11;11(4) PMID: 32788381 PMCID: PMC7439469 SCOPUS ID: 2-s2.0-85089602052 08/14/2020
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Tetanus Toxin cis-Loop Contributes to Light-Chain Translocation.
(Zuverink M, Bluma M, Barbieri JT.) mSphere. 2020 05 06;5(3) PMID: 32376703 PMCID: PMC7203457 SCOPUS ID: 2-s2.0-85084398090 05/08/2020
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(Chen C, Yang C, Barbieri JT.) Sci Rep. 2019 03 12;9(1):4211 PMID: 30862940 PMCID: PMC6414612 SCOPUS ID: 2-s2.0-85062821069 03/14/2019
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(Blum FC, Barbieri JT.) Encyclopedia of Microbiology. 1 January 2019:197-205 SCOPUS ID: 2-s2.0-85079533166 01/01/2019
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Light Chain Diversity among the Botulinum Neurotoxins.
(Gardner AP, Barbieri JT.) Toxins (Basel). 2018 07 02;10(7) PMID: 30004421 PMCID: PMC6070880 SCOPUS ID: 2-s2.0-85049650896 07/14/2018
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The Light Chain Defines the Duration of Action of Botulinum Toxin Serotype A Subtypes.
(Pellett S, Bradshaw M, Tepp WH, Pier CL, Whitemarsh RCM, Chen C, Barbieri JT, Johnson EA.) mBio. 2018 03 27;9(2) PMID: 29588398 PMCID: PMC5874905 SCOPUS ID: 2-s2.0-85046411664 03/29/2018
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Enhancing toxin-based vaccines against botulism.
(Przedpelski A, Tepp WH, Zuverink M, Johnson EA, Pellet S, Barbieri JT.) Vaccine. 2018 02 01;36(6):827-832 PMID: 29307477 PMCID: PMC5820173 SCOPUS ID: 2-s2.0-85039912971 01/09/2018
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Detection of ADP-Ribosylating Bacterial Toxins.
(Chen C, Barbieri JT.) Methods Mol Biol. 2018;1813:287-295 PMID: 30097876 SCOPUS ID: 2-s2.0-85051506237 08/12/2018
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Protein Toxins That Utilize Gangliosides as Host Receptors.
(Zuverink M, Barbieri JT.) Prog Mol Biol Transl Sci. 2018;156:325-354 PMID: 29747819 PMCID: PMC6243200 SCOPUS ID: 2-s2.0-85043989897 05/12/2018
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Protein Structure Facilitates High-Resolution Immunological Mapping.
(Zuverink M, Barbieri JT.) Clin Vaccine Immunol. 2017 Dec;24(12) PMID: 29046310 PMCID: PMC5717179 10/20/2017
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When Escherichia coli doesn't fit the mold: A pertussis-like toxin with altered specificity.
(Chen C, Barbieri JT.) J Biol Chem. 2017 09 08;292(36):15159-15160 PMID: 28887436 PMCID: PMC5592690 SCOPUS ID: 2-s2.0-85029216082 09/10/2017
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(Sundeen G, Barbieri JT.) Toxins (Basel). 2017 09 02;9(9) PMID: 28869493 PMCID: PMC5618201 SCOPUS ID: 2-s2.0-85028746538 09/05/2017