
Joseph T. Barbieri, PhD
Professor, Microbiology & Immunology; Associate Director, Medical Scientist Training Program
Locations
- Microbiology & Immunology
BSB B2830
Contact Information
General Interests
Education
Research Interests
My laboratory studies the molecular basis of microbial pathogenesis in Cellular Microbiology where components of the pathogen and host are analyzed to understand the pathogenic process. My research involves the study of bacterial toxins. Several families of bacterial toxins are under investigation: botulinum and tetanus neurotoxins; Certhrax, an ADP-ribosylating exotoxin from Bacillus cereus; and ExoS, a type III cytotoxin of Pseudomonas aeruginosa.
Publications
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(Gardner AP, Barbieri JT, Pellett S.) Toxins (Basel). 2022 Nov 22;14(12) PMID: 36548711 PMCID: PMC9783275 SCOPUS ID: 2-s2.0-85144580787 12/23/2022
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Genetically detoxified tetanus toxin as a vaccine and conjugate carrier protein.
(Chang MJ, Ollivault-Shiflett M, Schuman R, Ngoc Nguyen S, Kaltashov IA, Bobst C, Rajagopal SP, Przedpelski A, Barbieri JT, Lees A.) Vaccine. 2022 Aug 19;40(35):5103-5113 PMID: 35871872 PMCID: PMC10336728 SCOPUS ID: 2-s2.0-85134728035 07/26/2022
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(Yang C, Barbieri JT, Dahms NM, Chen C.) Biochemistry. 2022 Apr 05;61(7):616-624 PMID: 35285627 PMCID: PMC9817067 SCOPUS ID: 2-s2.0-85127145605 03/15/2022
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(Gardner A, Tepp WH, Bradshaw M, Barbieri JT, Pellett S.) Int J Mol Sci. 2021 Oct 15;22(20) PMID: 34681775 PMCID: PMC8539409 SCOPUS ID: 2-s2.0-85116984877 10/24/2021
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A Novel High-Potency Tetanus Vaccine.
(Przedpelski A, Tepp WH, Pellett S, Johnson EA, Barbieri JT.) mBio. 2020 Aug 11;11(4) PMID: 32788381 PMCID: PMC7439469 SCOPUS ID: 2-s2.0-85089602052 08/14/2020
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Tetanus Toxin cis-Loop Contributes to Light-Chain Translocation.
(Zuverink M, Bluma M, Barbieri JT.) mSphere. 2020 May 06;5(3) PMID: 32376703 PMCID: PMC7203457 SCOPUS ID: 2-s2.0-85084398090 05/08/2020
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Resolving the Molecular Steps in Clostridial Neurotoxin Light Chain Translocation.
(Zuverink M, Barbieri JT.) J Exp Neurol. 2020;1(4):123-134 PMID: 33615314 PMCID: PMC7894615 02/23/2021
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(Chen C, Yang C, Barbieri JT.) Sci Rep. 2019 Mar 12;9(1):4211 PMID: 30862940 PMCID: PMC6414612 SCOPUS ID: 2-s2.0-85062821069 03/14/2019
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(Blum FC, Barbieri JT.) Encyclopedia of Microbiology. 1 January 2019:197-205 SCOPUS ID: 2-s2.0-85079533166 01/01/2019
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Light Chain Diversity among the Botulinum Neurotoxins.
(Gardner AP, Barbieri JT.) Toxins (Basel). 2018 Jul 02;10(7) PMID: 30004421 PMCID: PMC6070880 SCOPUS ID: 2-s2.0-85049650896 07/14/2018
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Detection of ADP-Ribosylating Bacterial Toxins.
(Chen C, Barbieri JT.) Methods Mol Biol. 2018;1813:287-295 PMID: 30097876 SCOPUS ID: 2-s2.0-85051506237 08/12/2018
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Protein Toxins That Utilize Gangliosides as Host Receptors.
(Zuverink M, Barbieri JT.) Prog Mol Biol Transl Sci. 2018;156:325-354 PMID: 29747819 PMCID: PMC6243200 SCOPUS ID: 2-s2.0-85043989897 05/12/2018