
Julian H. Lombard, PhD
Professor; Physiology Course Director
Locations
- Physiology
Contact Information
Education
MS, Zoology, Arizona State University, 1971
BA, Biological Sciences, University of Texas, El Paso, 1969
Research Interests
Current research in this laboratory utilizes television microscopy, optical Doppler velocity measurements, oxygen microelectrodes, electrophysiological techniques and molecular biology to investigate the mechanisms by which changes in oxygen availability regulate active tone in microvessels and small resistance arteries and how elevated dietary salt intake affects vascular control in salt-sensitive hypertension and in normotensive animals that are not salt-sensitive. We previously demonstrated that resistance vessels of hypertensive animals exhibit an enhanced constriction in response to elevated PO2, and a reduced dilation in response to decreased PO2. We have also found that consumption of a high salt diet leads to a dramatic reduction in the ability of blood vessels to relax and increase blood flow to critical organs, and that this occurs without an increase in blood pressure.
A major goal of our work is to determine the mechanisms of the altered response of arterioles and small resistance arteries to changes in oxygen availability in hypertension. Another major goal of our laboratory is to identify the mechanisms by which high salt diet leads to impaired vascular function, even in the absence of an elevation in blood pressure. We are also investigating the role of circulating angiotensin II (ANG II) in maintaining normal vascular relaxation mechanisms using novel genetic rat strains [salt sensitive (SS) rats and consomic SS.13 BN rats) that differ in their ability to regulate their renin-angiotensin system and maintain normal circulating ANG II levels. In those studies, restoration of normal regulation of ANG II by substitution of the Brown Norway chromosome 13 (in SS.13 BN consomic rats) restores normal vascular relaxation mechanisms that are lost in SS rats, even when they are fed a low salt diet.
Publications
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High salt diet impairs cerebral blood flow regulation via salt-induced angiotensin II suppression.
(Allen LA, Schmidt JR, Thompson CT, Carlson BE, Beard DA, Lombard JH.) Microcirculation. 2019 04;26(3):e12518 PMID: 30481399 PMCID: PMC6465152 SCOPUS ID: 2-s2.0-85060177536 11/28/2018
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Do computers dream of electric glomeruli?
(Bukowy JD, Dayton A, Cloutier D, Lombard JH, Solberg Woods LC, Beard DA, Cowley AW Jr.) Kidney Int. 2018 09;94(3):635 PMID: 30143073 PMCID: PMC6110099 SCOPUS ID: 2-s2.0-85051364346 08/26/2018
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(Matic A, Jukic I, Stupin A, Baric L, Mihaljevic Z, Unfirer S, Tartaro Bujak I, Mihaljevic B, Lombard JH, Drenjancevic I.) Am J Physiol Heart Circ Physiol. 2018 09 01;315(3):H718-H730 PMID: 29906224 SCOPUS ID: 2-s2.0-85058153813 06/16/2018
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(Bukowy JD, Dayton A, Cloutier D, Manis AD, Staruschenko A, Lombard JH, Solberg Woods LC, Beard DA, Cowley AW Jr.) J Am Soc Nephrol. 2018 08;29(8):2081-2088 PMID: 29921718 PMCID: PMC6065078 SCOPUS ID: 2-s2.0-85050939134 06/21/2018
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(Lombard JH.) Acta Physiol (Oxf). 2018 01;222(1) PMID: 28834278 SCOPUS ID: 2-s2.0-85030028492 08/24/2017
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(Lukaszewicz KM, Durand MJ, Priestley JRC, Schmidt JR, Allen LA, Geurts AM, Lombard JH.) J Vis Exp. 2017 12 05(130) PMID: 29286398 PMCID: PMC5755532 SCOPUS ID: 2-s2.0-85037691517 12/30/2017
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Mechanisms of Mas1 Receptor-Mediated Signaling in the Vascular Endothelium.
(Hoffmann BR, Stodola TJ, Wagner JR, Didier DN, Exner EC, Lombard JH, Greene AS.) Arterioscler Thromb Vasc Biol. 2017 Mar;37(3):433-445 PMID: 28082260 PMCID: PMC5323371 SCOPUS ID: 2-s2.0-85010845201 01/14/2017
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(Lukaszewicz KM, Paudyal MP, Falck JR, Lombard JH.) Microcirculation. 2016 10;23(7):540-548 PMID: 27537772 PMCID: PMC5083157 SCOPUS ID: 2-s2.0-84992643512 10/28/2016
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(Frisbee JC, Butcher JT, Frisbee SJ, Olfert IM, Chantler PD, Tabone LE, d'Audiffret AC, Shrader CD, Goodwill AG, Stapleton PA, Brooks SD, Brock RW, Lombard JH.) Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H488-504 PMID: 26702145 PMCID: PMC4796615 SCOPUS ID: 2-s2.0-84958568627 12/25/2015
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(Priestley JR, Kautenburg KE, Casati MC, Endres BT, Geurts AM, Lombard JH.) Am J Physiol Heart Circ Physiol. 2016 Feb 15;310(4):H478-87 PMID: 26637559 PMCID: PMC4796617 SCOPUS ID: 2-s2.0-84958559081 12/08/2015
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(Raffai G, Lombard JH.) J Vasc Res. 2016;53(1-2):105-118 PMID: 27676088 PMCID: PMC5079160 SCOPUS ID: 2-s2.0-84989260698 10/19/2016
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Salt, Angiotensin II, Superoxide, and Endothelial Function.
(Boegehold MA, Drenjancevic I, Lombard JH.) Compr Physiol. 2015 Dec 15;6(1):215-54 PMID: 26756632 SCOPUS ID: 2-s2.0-85015046168 01/13/2016