Kyler Crawford
G4 Student
Faculty Advisor
- Brian Volkman, PhD, Biochemistry
Locations
- Medical Scientist Training Program
Contact Information
Education
BS, Medical Microbiology and Immunology/Integrated Liberal Studies, University of Wisconsin-Madison, 2012
Research Interests
GPCR structural biology / Chemokine immunology and cancer biology
I study the chemokine receptor ACKR1/DARC, a 7-TM receptor that regulates chemokine signals involved in cell migration and inflammation. The chemokine network coordinates cell migration, but can be hijacked by cancer cells to facilitate metastasis. I hope to understand the protective scavenging mechanisms of ACKR1/DARC and its role in patient health.
Research Experience
Medical College of Wisconsin, 2019-present
Advisor: Brian Volman, PhD
Project: Chemokine regulation and metastasis suppression by the atypical chemokine receptor DARC/ACKR1
Midwestern University, 2014-2016
Advisor: Jose Hernandez, PhD
Project: Zur and ZntR control zinc homeostasis in Klebsiella oxytoca: Biochemical characterization and application in high-throughput screening
University of Wisconsin-Madison, 2010-2012
Advisor: David Andes, MD
Project: Antifungal resistance mechanisms of Candida albicans biofilms
Publications
Gutjahr JC, Crawford KS, Jensen DR, Naik P, Peterson FC, Samson GPB, Legler DF, Duchene J, Veldkamp CT, Rot A, Volkman BF. The dimeric form of CXCL12 binds to atypical chemokine receptor 1. Sci Signal. 2021 Aug 17;14(696):eabc9012. doi: 10.1126/scisignal.abc9012. PMID: 34404752.
Wedemeyer MJ, Mahn SA, Getschman AE, Crawford KS, et al. The chemokine X-factor: Structure-function analysis of the CXC motif at CXCR4 and ACKR3. J Biol Chem. 2020 Oct 2;295(40):13927-13939. doi: 10.1074/jbc.RA120.014244. Epub 2020 Aug 11. PMID: 32788219; PMCID: PMC7535910.
Meeting Abstracts
Crawford, KC, Gutjahr, J, Peterson, FC, Veldkamp, CT, Rot, A, Volkman, BF. (2021, February 5). Interaction of CXCL12/SDF1 and atypical chemokine receptor 1 (ACKR1/DARC) [Poster] 30th Annual MCW Graduate School & Office of Postdoctoral Education Research Poster Session, Milwaukee, WI.
Crawford, KC, Gutjahr, J, Peterson, FC, Veldkamp, CT, Rot, A, Volkman, BF. (2021, March 27). The amino-terminus of atypical chemokine receptor 1 (ACKR1/DARC) exhibits binding affinity for the chemokine CXCL12 (SDF-1) [Presentation] 4th Annual MCW Graduate Student Association Research Symposium, Milwaukee, WI.
Crawford, KC, Gutjahr, J, Peterson, FC, Veldkamp, CT, Rot, A, Volkman, BF. (2021, April 29). Dimeric form of CXCL12/SDF1 binds to atypical chemokine receptor 1 (ACKR1/DARC) [Presentation] ASBMB 2021 Experimental Biology Conference, Virtual.”
General Interests
Basketball, my dog, music, cycling