Medical College of Wisconsin
Medical College of Wisconsin Medical College of Wisconsin

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Staff Collaborate Conference Room

Kyler Crawford

Kyler Crawford

Kyler Crawford

G3 Student

Faculty Advisor

  • Brian Volkman, PhD, Biochemistry

Locations

  • Medical Scientist Training Program

Contact Information

Education

MS, Biomedical Science, Midwestern University, 2016
BS, Medical Microbiology and Immunology/Integrated Liberal Studies, University of Wisconsin-Madison, 2012

Research Interests

GPCR structure and function, immunology and cancer biology.

I study the chemokine receptor DARC/ACKR1, a 7TM receptor that regulates chemokine signals involved in cell migration and inflammation. The chemokine network can be hijacked by cancer cells to facilitate metastasis, and I hope to understand the protective scavenging mechanisms of DARC/ACKR1

Research Experience

Medical College of Wisconsin, 2019-present
Advisor: Brian Volman, PhD
Project: Chemokine regulation and metastasis suppression by the atypical chemokine receptor DARC/ACKR1

Midwestern University, 2014-2016
Advisor: Jose Hernandez, PhD
Project: Zur and ZntR control zinc homeostasis in Klebsiella oxytoca: Biochemical characterization and application in high-throughput screening

University of Wisconsin-Madison, 2010-2012
Advisor: David Andes, MD
Project: Antifungal resistance mechanisms of Candida albicans biofilms

Publications

Wedemeyer MJ, Mahn SA, Getschman AE, Crawford KS, et al. The chemokine X-factor: Structure-function analysis of the CXC motif at CXCR4 and ACKR3. J Biol Chem. 2020 Oct 2;295(40):13927-13939. doi: 10.1074/jbc.RA120.014244. Epub 2020 Aug 11. PMID: 32788219; PMCID: PMC7535910.

Meeting Abstracts

Crawford, KC, Gutjahr, J, Peterson, FC, Veldkamp, CT, Rot, A, Volkman, BF. (2021, February 5). Interaction of CXCL12/SDF1 and atypical chemokine receptor 1 (ACKR1/DARC) [Poster] 30th Annual MCW Graduate School & Office of Postdoctoral Education Research Poster Session, Milwaukee, WI.

Crawford, KC, Gutjahr, J, Peterson, FC, Veldkamp, CT, Rot, A, Volkman, BF. (2021, March 27). The amino-terminus of atypical chemokine receptor 1 (ACKR1/DARC) exhibits binding affinity for the chemokine CXCL12 (SDF-1) [Presentation] 4th Annual MCW Graduate Student Association Research Symposium, Milwaukee, WI.

Crawford, KC, Gutjahr, J, Peterson, FC, Veldkamp, CT, Rot, A, Volkman, BF. (2021, April 29). Dimeric form of CXCL12/SDF1 binds to atypical chemokine receptor 1 (ACKR1/DARC) [Presentation] ASBMB 2021 Experimental Biology Conference, Virtual.”

General Interests

Basketball, my dog, music, cycling