Mohamed Khalil

Adaptive NK cells, viral immuno-oncology, bioinformatics

Research Experience

Medical College of Wisconsin, 2020-present
Advisors: Subramaniam Malarkannan, PhD and Scott Terhune, PhD
Project: Single-cell transcriptome of anti-viral NK cells

Illinois State University, 2014-2015
Advisor: Andres Vidal-Gadea, PhD
Project: Identify molecular machinery responsible for C. elegans ability to detect and orient to magnetic fields.

Illinois State University, 2015-2016
Advisor: Andres Vidal-Gadea, PhD
Project: Demonstrated that the nematode C. elegans is a viable system to study both the molecular and neuronal aspects of Angelman Syndrome.

Publications

Khalil M, Malarkannan S. Innatus Immunis: Evolving paradigm of adaptive NK cells. Journal of Experimental Medicine 2022;1254. doi: 10.1084/jem.20221254. PMID: 36066493.

Khalil M, Mei A, Hashemi E, Wang D, Schumacher M, Terhune S, Malarkannan S. Method to Study Adaptive NK Cells Following MCMV Infections. Methods Mol Biol. 2022;2463:195-204. doi: 10.1007/978-1-0716-2160-8_14. PMID: 35344176.

Wang D, Burns R, Khalil M, Mei A, Hashemi E, Malarkannan S. Methods to Analyze the Developmental Trajectory of Human Primary NK Cells Using Monocle and SCENIC Analyses. Methods Mol Biol. 2022;2463:81-102. doi: 10.1007/978-1-0716-2160-8_7. PMID: 35344169.

Mei A, Hashemi E, Khalil M, Wang D, Malarkannan S. Isolation of Innate Lymphoid Cells from Murine Intestinal Lamina Propria. Methods Mol Biol. 2022;2463:3-9. doi: 10.1007/978-1-0716-2160-8_1. PMID: 35344163.

Hashemi E, Mei A, Wang D, Khalil M, Malarkannan S. Methods for Isolating and Defining Single-Cell Transcriptomes of Tissue-Resident Human NK Cells. Methods Mol Biol. 2022;2463:103-116. doi: 10.1007/978-1-0716-2160-8_8. PMID: 35344170.

Khalil M, Wang D, Hashemi E, Terhune SS, Malarkannan S. Implications of a 'Third Signal' in NK Cells. Cells. 2021 Jul 31;10(8):1955. doi: 10.3390/cells10081955. PMID: 34440725; PMCID: PMC8393955. 

Meeting Abstracts

Khalil M, Terhune SS, Malarkannan S. Cytomegalovirus infection induces the generation of NKG2CHi fetal NK cells in the umbilical cord. Midwest TL1 Summit. Wauwatosa, WI. September 2023

Khalil M, Terhune SS, Malarkannan S. Human cytomegalovirus (HCMV) infection drives the formation of NKG2CHi memory NK cells that express elevated levels of IL-7R and cyto-CD3e. 38th Annual MD-PhD National Student Conference. Copper Mountain, CO. July 2023 [Diversity Travel Award]

Khalil M, Terhune SS, Malarkannan S. Interleukin-7 Receptor (IL7R) and CD3E are necessary for the formation of NKG2CHi adaptive NK cells during HCMV infections. 13th Annual Immunology Scientific Retreat, Center for Immunology. Wauwatosa, WI. June 2023 [Top Abstract Award]

Khalil M, Terhune SS, Malarkannan S. Single cell transcriptomes from HCMV+ donors reveal a unique NKG2CHi subset that represents true memory NK cells. American Association of Immunologist 2023. Washington, D.C. May 2023 [Abstract Trainee Award]

Khalil M, Terhune SS, Malarkannan S. Defining the single-cell transcriptomes of splenic adaptive Natural Killer cells in donors with latent human cytomegalovirus infection. Association for Clinical and Translation Sciences. Washington, D.C. April 2023 [Outstanding Trainee Award]

Khalil M, Terhune SS, Malarkannan S. Interleukin-7 Receptor (IL7R) and CD3E are necessary for the development and function of NKG2CHi memory-like NK cells during HCMV infections. 6th Annual Graduate School Symposium. Milwaukee, WI. April 2023

Khalil M, Terhune SS, Malarkannan S. Single-cell transcriptomes reveal a unique NKG2CHi population representing memory NK cells. MCW Research Week. Wauwatosa, WI. March 2023

Khalil M, Terhune SS, Malarkannan S. Single-cell transcriptome from the spleen of HCMV+ donors reveal a unique subset of NKG2C+ population that represent true memory NK cells. Department of Medicine. Wauwatosa, WI. March 2023 [Best Poster Award]

Khalil M, Terhune SS, Malarkannan S. Single-cell transcriptome of human adaptive NK cells reveal a unique transcriptional program that governs its development and function. Autumn Immunology Conference. Chicago, IL. November 2022 [Trainee Travel Award]

Khalil M, Terhune SS, Malarkannan S. Single-cell transcriptome of HCMV seropositive individuals reveals a unique subset of NKG2C+ cells that represent adaptive NK cells. 32nd Annual Graduate School Poster Session. Wauwatosa, WI. October 2022

Khalil M, Terhune SS, Malarkannan S. Transcriptome of human adaptive NK cells reveal a unique transcriptional program that governs its development and function. 11th Annual CTSI Milwaukee Regional Research Forum. Milwaukee, WI. October 2022

Khalil M, Terhune SS, Malarkannan S. Transcriptomic profiling of human Adaptive NK cells derived from HCMV seropositive individuals. 1st Annual Midwest TL1 Research Summit. Madison, WI. September 2022

Khalil M, Terhune SS, Malarkannan S. Defining the Human Cytomegalovirus manipulation of NK cells at a single-cell resolution. 12th Annual Immunology Scientific Retreat, Center for Immunology. Wauwatosa, WI. June 2022

Khalil M, Patel J.J, Baruah D, Rein L.R, Tsai S, Clarke C, T. Gamblin C, Mogal H. Association of Muscle Quantity and Frailty on Short-term Outcomes of CRS/HIPEC in Patients with Appendiceal cancer. SSO 2020 International Advanced Cancer Therapies. Orlando, Florida. February 2020 [Trainee Travel Award] "

General Interests

Traveling, running, snowboarding, scuba diving, reading and MMA