Nathan A. Ledeboer, PhD

Professor; Medical Director, Clinical Microbiology; Medical Director, Molecular Diagnostics

Locations

Pathology & Laboratory Medicine

Contact Information

Biography

Dr. Ledeboer’s primary responsibility is for the medical and technical oversight of the Clinical Microbiology and Molecular Diagnostics Laboratories. In this role he oversees development and implementation of new assays, oversees and sign out all testing performed in these laboratories, and consults with physician colleagues regarding test results and selection.

Specialties:

Clinical Microbiology
Molecular Pathology

Research Interests

Development of rapid molecular techniques for detection of infectious diseases

Host Response to Infection

Combining Digital Imaging and Artificial Intelligence

Molecular detection and epidemiology of Respiratory Viruses

Antimicrobial resistance

Toxigenic Clostridioides difficile colonization as a risk factor for development of C. difficile infection in solid-organ transplant patients.

(Keegan J, Buchan BW, Ledeboer NA, Zhou Z, Hong JC, Graham MB, Munoz-Price LS.) Infect Control Hosp Epidemiol. 2020 Sep 16:1-5 PMID: 32933595 SCOPUS ID: 2-s2.0-85092160301 09/17/2020
Distribution of SARS-CoV-2 PCR Cycle Threshold Values Provide Practical Insight Into Overall and Target-Specific Sensitivity Among Symptomatic Patients.

(Buchan BW, Hoff JS, Gmehlin CG, Perez A, Faron ML, Munoz-Price LS, Ledeboer NA.) Am J Clin Pathol. 2020 09 08;154(4):479-485 PMID: 32687186 PMCID: PMC7454307 SCOPUS ID: 2-s2.0-85091263722 07/21/2020
Evaluation of NG-Test Carba 5 for Rapid Phenotypic Detection and Differentiation of Five Common Carbapenemase Families: Results of a Multicenter Clinical Evaluation.

(Jenkins S, Ledeboer NA, Westblade LF, Burnham CA, Faron ML, Bergman Y, Yee R, Mesich B, Gerstbrein D, Wallace MA, Robertson A, Fauntleroy KA, Klavins AS, Malherbe R, Hsiung A, Simner PJ.) J Clin Microbiol. 2020 Jun 24;58(7) PMID: 32376668 PMCID: PMC7315033 SCOPUS ID: 2-s2.0-85086924996 05/08/2020
Practical Comparison of the BioFire FilmArray Pneumonia Panel to Routine Diagnostic Methods and Potential Impact on Antimicrobial Stewardship in Adult Hospitalized Patients with Lower Respiratory Tract Infections.

(Buchan BW, Windham S, Balada-Llasat JM, Leber A, Harrington A, Relich R, Murphy C, Dien Bard J, Naccache S, Ronen S, Hopp A, Mahmutoglu D, Faron ML, Ledeboer NA, Carroll A, Stone H, Akerele O, Everhart K, Bonwit A, Kwong C, Buckner R, Warren D, Fowler R, Chandrasekaran S, Huse H, Campeau S, Humphries R, Graue C, Huang A.) J Clin Microbiol. 2020 Jun 24;58(7) PMID: 32350045 PMCID: PMC7315039 SCOPUS ID: 2-s2.0-85086931042 05/01/2020
Multicenter Clinical Evaluation of the Revogene Strep A Molecular Assay for Detection of Streptococcus pyogenes from Throat Swab Specimens.

(Banerjee D, Michael J, Schmitt B, Salimnia H, Mhaissen N, Goldfarb DM, Lachance P, Faron ML, Aufderheide T, Ledeboer N, Weissfeld A, Selvarangan R.) J Clin Microbiol. 2020 Jun 24;58(7) PMID: 32321780 PMCID: PMC7315036 SCOPUS ID: 2-s2.0-85086930057 04/24/2020
Achromobacter xylosoxidans Cellular Pathology Is Correlated with Activation of a Type III Secretion System.

(Pickrum AM, DeLeon O, Dirck A, Tessmer MH, Riegert MO, Biller JA, Ledeboer NA, Kirby JR, Frank DW.) Infect Immun. 2020 Jun 22;88(7) PMID: 32366575 PMCID: PMC7309624 SCOPUS ID: 2-s2.0-85088536617 05/06/2020
Evaluation of the WASPLab Segregation Software To Automatically Analyze Urine Cultures Using Routine Blood and MacConkey Agars.

(Faron ML, Buchan BW, Relich RF, Clark J, Ledeboer NA.) J Clin Microbiol. 2020 03 25;58(4) PMID: 31941690 PMCID: PMC7098764 SCOPUS ID: 2-s2.0-85082542587 01/17/2020
A Multicenter Study of the Revogene C. difficile System for Detection of the Toxin B Gene from Unformed Stool Specimens.

(Mashock MJ, Faron ML, Carroll KC, Dang C, Lewis S, Salimnia H, Lephart P, Loo VG, Schmitt BH, Young S, Buchan BW, Ledeboer NA.) J Clin Microbiol. 2020 01 28;58(2) PMID: 31776191 PMCID: PMC6989061 SCOPUS ID: 2-s2.0-85078685786 11/30/2019
Association Between Environmental Factors and Toxigenic Clostridioides difficile Carriage at Hospital Admission.

(Muñoz-Price LS, Hanson R, Singh S, Nattinger AB, Penlesky A, Buchan BW, Ledeboer NA, Beyer K, Namin S, Zhou Y, Pezzin LE.) JAMA Netw Open. 2020 01 03;3(1):e1919132 PMID: 31922563 PMCID: PMC6991319 SCOPUS ID: 2-s2.0-85077730785 01/11/2020
Direct detection of intact Klebsiella pneumoniae carbapenemase variants from cell lysates: Identification, characterization and clinical implications

(McGee WM, Faron ML, Neil JR, Kronewitter SR, Buchan BW, Ledeboer NA, Stephenson JL.) Clinical Mass Spectrometry. August 2020;17:12-21 SCOPUS ID: 2-s2.0-85089093667 08/01/2020
Evaluation of WASPLab Software To Automatically Read chromID CPS Elite Agar for Reporting of Urine Cultures.

(Faron ML, Buchan BW, Samra H, Ledeboer NA.) J Clin Microbiol. 2019 12 23;58(1) PMID: 31694967 PMCID: PMC6935927 SCOPUS ID: 2-s2.0-85077223772 11/07/2019
Multicenter Study Demonstrates Standardization Requirements for Mold Identification by MALDI-TOF MS.

(Lau AF, Walchak RC, Miller HB, Slechta ES, Kamboj K, Riebe K, Robertson AE, Gilbreath JJ, Mitchell KF, Wallace MA, Bryson AL, Balada-Llasat JM, Bulman A, Buchan BW, Burnham CD, Butler-Wu S, Desai U, Doern CD, Hanson KE, Henderson CM, Kostrzewa M, Ledeboer NA, Maier T, Pancholi P, Schuetz AN, Shi G, Wengenack NL, Zhang SX, Zelazny AM, Frank KM.) Front Microbiol. 2019;10:2098 PMID: 31616388 PMCID: PMC6764242 10/17/2019

Nathan A. Ledeboer, PhD