Nathan A. Ledeboer, PhD

Professor; Medical Director, Clinical Microbiology; Medical Director, Molecular Diagnostics

Locations

Pathology & Laboratory Medicine

Contact Information

Biography

Dr. Ledeboer’s primary responsibility is for the medical and technical oversight of the Clinical Microbiology and Molecular Diagnostics Laboratories. In this role he oversees development and implementation of new assays, oversees and sign out all testing performed in these laboratories, and consults with physician colleagues regarding test results and selection.

Specialties:

Clinical Microbiology
Molecular Pathology

Research Interests

Development of rapid molecular techniques for detection of infectious diseases

Host Response to Infection

Combining Digital Imaging and Artificial Intelligence

Molecular detection and epidemiology of Respiratory Viruses

Antimicrobial resistance

Toxigenic Clostridioides difficile colonization as a risk factor for development of C. difficile infection in solid-organ transplant patients.

(Keegan J, Buchan BW, Ledeboer NA, Zhou Z, Hong JC, Graham MB, Munoz-Price LS.) Infect Control Hosp Epidemiol. 2021 Mar;42(3):287-291 PMID: 32933595 SCOPUS ID: 2-s2.0-85092160301 09/17/2020
Impact of an Antimicrobial Stewardship Program Pharmacist During Microbiology Rounds.

(Sapozhnikov J, Huang A, Revolinski S, Ledeboer NA, Buchan BW.) Am J Clin Pathol. 2021 02 11;155(3):455-460 PMID: 32949141 SCOPUS ID: 2-s2.0-85102099001 09/20/2020
Digital Image Analysis for the Detection of Group B Streptococcus from ChromID Strepto B Medium Using PhenoMatrix Algorithms.

(Baker J, Timm K, Faron M, Ledeboer N, Culbreath K.) J Clin Microbiol. 2020 12 17;59(1) PMID: 33087433 PMCID: PMC7771474 SCOPUS ID: 2-s2.0-85098517412 10/23/2020
A Multi-mRNA Host-Response Molecular Blood Test for the Diagnosis and Prognosis of Acute Infections and Sepsis: Proceedings from a Clinical Advisory Panel.

(Ducharme J, Self WH, Osborn TM, Ledeboer NA, Romanowsky J, Sweeney TE, Liesenfeld O, Rothman RE.) J Pers Med. 2020 Dec 07;10(4) PMID: 33297498 PMCID: PMC7762405 12/11/2020
Decrease in Positivity Rate of Influenza Tests Coinciding With Outbreak of SARS-CoV-2: Data From a Southeastern Wisconsin Laboratory.

(Singh S, Ledeboer NA, Laud PW, Hanson R, Truwit JD.) WMJ. 2020 Dec;119(4):275-277 PMID: 33428839 SCOPUS ID: 2-s2.0-85099899804 01/12/2021
Distribution of SARS-CoV-2 PCR Cycle Threshold Values Provide Practical Insight Into Overall and Target-Specific Sensitivity Among Symptomatic Patients.

(Buchan BW, Hoff JS, Gmehlin CG, Perez A, Faron ML, Munoz-Price LS, Ledeboer NA.) Am J Clin Pathol. 2020 09 08;154(4):479-485 PMID: 32687186 PMCID: PMC7454307 SCOPUS ID: 2-s2.0-85091263722 07/21/2020
Racial Disparities in Incidence and Outcomes Among Patients With COVID-19.

(Muñoz-Price LS, Nattinger AB, Rivera F, Hanson R, Gmehlin CG, Perez A, Singh S, Buchan BW, Ledeboer NA, Pezzin LE.) JAMA Netw Open. 2020 09 01;3(9):e2021892 PMID: 32975575 PMCID: PMC7519420 SCOPUS ID: 2-s2.0-85091807867 09/26/2020
Evaluation of NG-Test Carba 5 for Rapid Phenotypic Detection and Differentiation of Five Common Carbapenemase Families: Results of a Multicenter Clinical Evaluation.

(Jenkins S, Ledeboer NA, Westblade LF, Burnham CA, Faron ML, Bergman Y, Yee R, Mesich B, Gerstbrein D, Wallace MA, Robertson A, Fauntleroy KA, Klavins AS, Malherbe R, Hsiung A, Simner PJ.) J Clin Microbiol. 2020 06 24;58(7) PMID: 32376668 PMCID: PMC7315033 SCOPUS ID: 2-s2.0-85086924996 05/08/2020
Practical Comparison of the BioFire FilmArray Pneumonia Panel to Routine Diagnostic Methods and Potential Impact on Antimicrobial Stewardship in Adult Hospitalized Patients with Lower Respiratory Tract Infections.

(Buchan BW, Windham S, Balada-Llasat JM, Leber A, Harrington A, Relich R, Murphy C, Dien Bard J, Naccache S, Ronen S, Hopp A, Mahmutoglu D, Faron ML, Ledeboer NA, Carroll A, Stone H, Akerele O, Everhart K, Bonwit A, Kwong C, Buckner R, Warren D, Fowler R, Chandrasekaran S, Huse H, Campeau S, Humphries R, Graue C, Huang A.) J Clin Microbiol. 2020 06 24;58(7) PMID: 32350045 PMCID: PMC7315039 SCOPUS ID: 2-s2.0-85086931042 05/01/2020
Multicenter Clinical Evaluation of the Revogene Strep A Molecular Assay for Detection of Streptococcus pyogenes from Throat Swab Specimens.

(Banerjee D, Michael J, Schmitt B, Salimnia H, Mhaissen N, Goldfarb DM, Lachance P, Faron ML, Aufderheide T, Ledeboer N, Weissfeld A, Selvarangan R.) J Clin Microbiol. 2020 06 24;58(7) PMID: 32321780 PMCID: PMC7315036 SCOPUS ID: 2-s2.0-85086930057 04/24/2020
Achromobacter xylosoxidans Cellular Pathology Is Correlated with Activation of a Type III Secretion System.

(Pickrum AM, DeLeon O, Dirck A, Tessmer MH, Riegert MO, Biller JA, Ledeboer NA, Kirby JR, Frank DW.) Infect Immun. 2020 06 22;88(7) PMID: 32366575 PMCID: PMC7309624 SCOPUS ID: 2-s2.0-85088536617 05/06/2020
Direct detection of intact Klebsiella pneumoniae carbapenemase variants from cell lysates: Identification, characterization and clinical implications

(McGee WM, Faron ML, Neil JR, Kronewitter SR, Buchan BW, Ledeboer NA, Stephenson JL.) Clinical Mass Spectrometry. August 2020;17:12-21 SCOPUS ID: 2-s2.0-85089093667 08/01/2020

Nathan A. Ledeboer, PhD