Nikki Johnston, PhD
Associate Professor, Otolaryngology & Communication Sciences and Microbiology & Immunology
- Otolaryngology & Communication Sciences
BS, Anatomical Sciences, University of Dundee, United Kingdom, 1999
Honors and Awards
Broyles-Maloney Award American Broncho-Esophagological Association Orlando, Florida - April 2013
Charles Ferguson Clinical Research Prize, American Society of Pediatric Otolaryngology - March 2013
2012 Faculty Service Award for service to the Faculty Council Committees of the MCW - October 2012
Marquis Who’s Who in America 2013 - January 2012
Marquis Who’s Who in Medicine and Healthcare 2012 - June 2011
American Cancer Society / MCW Cancer Center Travel Award, to attend and present at the annual AACR conference, Orlando, Florida - March 2011
Broyles-Maloney Award, American Broncho-Esophagological Association, Phoenix, Arizona - May 2009
Broyles-Maloney Award, American Broncho-Esophagological Association, Orlando, Florida - May 2008
Best Abstract and Travel Award, The Union of European Gastroenterology Week, Copenhagen, Denmark - July 2005
Key Note Presentation, World Organization for Specialized Studies on Disease of the Esophagus, Paris, France - September 2003
Best Abstract and Travel Award, The Union of European Gastroenterology Week, Geneva, Switzerland - October 2002
- Extraesophageal reflux
- Use of pepsin as a marker for extraesophageal reflux
- Uptake of pepsin by laryngeal epithelial cells & its role in reflux - attributed laryngeal injury & disease
- Isolate and identification of the receptor with which pepsin interacts on laryngeal epithelial cells
- New therapeutics for reflux (pepsin inhibitors/receptor antagonists)
- Role of reflux, specifically pepsin, in laryngopharyngeal cancers
- Role of pepsin in Barrett’s esophagus and esophageal adenocarcinoma
Dr. Johnston’s research laboratory aims to test pepsin, as a marker for reflux, in clinical tissue and secretion samples from patients with diseases of the upper airway, demonstrate the effect of nonacid pepsin on respiratory epithelium using in vitro and in vivo models, and identify the molecular signaling pathways through which nonacid pepsin elicits cell damage. She has been investigating the role of reflux, specifically pepsin, in injury and disease of the aero-digestive tract for several years now. Dr. Johnston has presented this work at national and international scientific and clinical meetings and directed two international conferences on extra-esophageal reflux disease, the future: diagnosis and treatment. She has published the data in several peer reviewed journals, contributed chapters for reflux-related books, and edited a book on this subject.
In addition to investigating the role of pepsin as a diagnostic marker for reflux and its role in the pathophysiology of reflux-attributed inflammatory disease, her group has highlighted a potential role for pepsin in carcinogenesis of the laryngopharynx. Her research team is currently performing experiments to elucidate pepsin as a promoter/causal agent involved in early events of carcinoma in the laryngopharynx, and to investigate the mechanism by which pepsin causes/contributes to inflammation and carcinogenesis in the laryngopharynx.
- American Association for Cancer Research
- Society for Bimolecular Sciences
- Association for Research in Otolaryngology
- American Broncho-Esophagological Association
- Medical College of Wisconsin Cancer Center
- Clinical and Translational Science Institute of Southeast Wisconsin
(Samuels TL, Altman KW, Gould JC, Kindel T, Bosler M, MacKinnon A, Hagen CE, Johnston N.) Laryngoscope. 2019 Dec;129(12):2687-2695.
(Klimara MJ, Samuels TL, Johnston N, Chun RH, McCormick ME.) Ann Otol Rhinol Laryngol. 2019 Oct 21:3489419884332.
(Hurley BP, Jugo RH, Snow RF, Samuels TL, Yonker LM, Mou H, Johnston N, Rosen R.) Sci Rep. 2019 Sep 24;9(1):13778.
(Klimara MJ, Johnston N, Samuels TL, Visotcky AM, Poetker DM, Loehrl TA, Blumin JH, Bock JM.) Laryngoscope. 2019 Jul 22.
(McCann AJ, Samuels TL, Blumin JH, Johnston N.) Laryngoscope. 2019 Feb 18.
(Marshall S, McCann AJ, Samuels TL, Blair A, Bonne V, Johnston N, Koufman J.) J Asthma Allergy. 2019;12:155-161.
(Johnston N, Dettmar PW, Ondrey FG, Nanchal R, Lee SH, Bock JM.) Ann N Y Acad Sci. 2018 12;1434(1):282-289.
(Luebke K, Samuels TL, Chelius TH, Sulman CG, McCormick ME, Kerschner JE, Johnston N, Chun RH.) Laryngoscope. 2017 10;127(10):2413-2417.
(Samuels TL, Yan JC, Khampang P, Dettmar PW, MacKinnon A, Hong W, Johnston N, Papsin BC, Chun RH, McCormick ME, Kerschner JE.) JAMA Otolaryngol Head Neck Surg. 2017 08 01;143(8):810-817.
(Preciado D, Granath A, Lin J, Val S, Kurabi A, Johnston N, Vijayasekaran S, Valdez T, Depireux D, Hermansson A.) Otolaryngol Head Neck Surg. 2017 04;156(4_suppl):S106-S113.
(Johnston N, Ondrey F, Rosen R, Hurley BP, Gould J, Allen J, DelGaudio J, Altman KW.) Ann N Y Acad Sci. 2016 10;1381(1):5-13.
(Klimara MJ, Nanchal R, Johnston N.) Reflux Aspiration and Lung Disease. 1 January 2018:235-244.