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Paul Auer, PhD
Paul Auer

Paul Auer, PhD

Cancer Center Scholar; Director, Biostatistics Shared Resource, Cancer Center; Professor, Data Science Institute, Biostatistics

Locations

  • Biostatistics, the Center for Cancer Discovery, N1164

Contact Information

Education

PhD, Purdue University, West Lafayette, IN, 2010
MPS, Cornell University, Ithaca, NY, 2003
BA, SUNY Geneseo, Geneseo, NY, 2001

Biography

Research Experience:
Statistical Genetics; GWAS, Complex Trait Genetics, Rare-Variants, Whole-Genome Sequencing

Research Interests

Dr. Auer is a statistical geneticist with expertise in the analysis of whole genome sequencing and multi-omic data. He has collaborated on several large-scale projects focused on understanding the genetic basis of complex diseases such as stroke, heart disease, and cancer. He collaborates with faculty in the Department of Physiology, the Center of International Blood & Marrow Transplant Research, and the MCW Cancer Center. His current research interests include multi-omic data analysis for predicting phenotypic states and disease outcomes and developing methods to detect clonal mosaicism.

Publications

  • Methylation profile of individuals with sickle cell trait.

    (Vasconcelos AG, Johnson M, Cai Y, Hsu L, Franceschini N, Auer PL, Kooperberg C, Raffield LM, Reiner AP.) Epigenetics. 2025 Dec;20(1):2539234 PMID: 40758858 PMCID: PMC12323419 08/04/2025

  • Integrating whole genome and transcriptome sequencing to characterize the genetic architecture of isoform variation.

    (Liu C, Joehanes R, Ma J, Xie J, Yang J, Wang M, Huan T, Hwang SJ, Wen J, Sun Q, Demirkale CY, Heard-Costa NL, Orchard P, Carson AP, Haessler JW, Raffield LM, Reiner AP, Franceschini N, Auer PL, Kooperberg C, Li Y, O'Connor G, Murabito JM, Munson P, Levy D.) Nat Commun. 2025 Nov 22;16(1):10615 PMID: 41274869 PMCID: PMC12660940 11/23/2025

  • Large-scale meta-analysis and precision functional assays identify FANCM regions in which PTVs confer different risks for ER-negative and triple-negative breast cancer.

    (Billaud A, Figlioli G, Mooser C, Casamassima I, Azzoni V, Srivatsa J, Colombo M, Caleca L, Ahearn TU, Andrulis IL, Antoniou AC, Beckmann MW, Behrens S, Bermisheva M, Bogdanova NV, Bolla MK, Bonanni B, Brüning T, Camp NJ, Campbell A, Castelao JE, Cessna MH, Chang-Claude J, NBCS Collaborators, Czene K, Dennis J, Devilee P, Dörk T, Dunning AM, Eriksson M, Evans DG, Fasching PA, Figueroa JD, Gabrielson M, Gago-Dominguez M, González-Neira A, Guénel P, Hadjisavvas A, Hahnen E, Hamann U, Hillemanns P, Hollestelle A, Hooning MJ, Hoppe R, Howell A, kConFab Investigators, Jakubowska A, Kristensen VN, Lubiński J, Lush M, Manoukian S, Mavroudis D, Milne RL, Mulligan AM, Newman WG, Obi N, Panayiotidis MI, Pita G, Rashid MU, Rhenius V, Saloustros E, Sawyer EJ, Schmutzler RK, Shah M, Southey MC, Spurdle AB, Tomlinson I, Truong T, Wang Q, Wendt C, Auer PL, Boddicker NJ, Bodelon C, Burnside ES, Chen F, Couch FJ, Domchek SM, Eliassen HA, Haiman C, Hodge JM, Hu C, Huang H, Lindstrom S, Martinez ME, Nathanson KL, Neuhausen SL, O'Brien KM, Olson JE, Palmer JR, Patel AV, Ruddy KJ, Sandler DP, Teras LR, Weinberg CR, Weitzel JN, Winham SJ, Yadav S, Yao S, Zirpoli G, Janatova M, Kleibl Z, Kleiblova P, Soukupova J, CZECANCA consortium, Zhao Q, Devereux L, James PA, Campbell IG, Nguyen-Dumont T, Dowty JG, Andrieu N, Lesueur F, Stoppa-Lyonnet D, GENESIS, Hoya M, Radice P, Sørensen CS, Peterlongo P.) Breast. 2025 Oct 30;85:104619 PMID: 41223770 PMCID: PMC12657754 11/13/2025

  • Genetic determinants and genomic consequences of non-leukemogenic somatic point mutations.

    (Weinstock JS, Chaudhry SA, Ioannou M, Viskadourou M, Reventun P, Jakubek YA, Liggett LA, Laurie C, Broome JG, Khan A, Taylor KD, Guo X, Peyser PA, Boerwinkle E, Chami N, Kenny EE, Loos RJ, Psaty BM, Tracy RP, Brody JA, Yun JH, Cho MH, Vasan RS, Kardia SL, Smith JA, Raffield LM, Bidulescu A, O'Brien EC, de Andrade M, Rotter JI, Rich SS, Tracy RP, Chen YI, Gu CC, Hsiung CA, Kooperberg C, Haring B, Nassir R, Mathias R, Reiner A, Sankaran VG, Lowenstein CJ, Blackwell TW, Abecasis GR, Smith AV, Kang HM, Natarajan P, Jaiswal S, Bick A, Post WS, Scheet P, Auer P, Karantanos T, Battle A, Arvanitis M.) Nat Commun. 2025 Oct 16;16(1):9194 PMID: 41102182 PMCID: PMC12532822 10/17/2025

  • Pathogenic Variants, Family History, and Cumulative Risk of Breast Cancer in US Women.

    (O'Brien KM, Keil AP, Taylor JA, Weinberg CR, Polley EC, Yadav S, Boddicker NJ, Hu C, Ambrosone CB, Anton-Culver H, Auer PL, Bodelon C, Brantley K, Burnside ES, Chen F, Domchek SM, Eliassen AH, Haiman CA, Hodge JM, Kraft P, Lacey JV, Lindstroem S, Martinez ME, Nathanson KL, Neuhausen SL, Olson JE, Palmer JR, Patel AV, Penney KL, Ruddy KJ, Scott CG, Teras LR, Trentham-Dietz A, Vachon CM, Weitzel JN, Yao S, Zirpoli G, Couch FJ, Sandler DP.) JAMA Oncol. 2025 Oct 09 PMID: 41066089 PMCID: PMC12512027 10/09/2025

  • Association of Genetic Predisposition to Inflammation With Cancer-Related Cognitive Impairment and Fatigue in Women Who Received Chemotherapy for Nonmetastatic Breast Cancer.

    (Olowofela AS, Auer PL, Janelsins M, Mustian K, Conlin A, Onitilo AA, Melnik M, Li CS, Gada U, Sun H, Kerns SL.) JCO Precis Oncol. 2025 Sep;9:e2500303 PMID: 40956996 PMCID: PMC12442773 09/16/2025

  • Race-related host and microbe transcriptomic signatures in triple-negative breast cancer.

    (Kumar R, Duyar-Ayerdi S, Sundaresan A, Srinivasasainagendra V, Pedamallu CS, Behring M, Chandrashekar DS, Eltoum IE, Varambally S, Tiwari HK, Shrestha S, Auer PL, Chaudhary LN, Kirby JR, Yates C, Manne U, Ojesina AI.) NPJ Breast Cancer. 2025 Aug 08;11(1):87 PMID: 40781241 PMCID: PMC12334597 SCOPUS ID: 2-s2.0-105012896561 08/09/2025

  • Genetic study of von Willebrand factor antigen levels ≤ 50 IU/dL identifies variants associated with increased risk of von Willebrand disease and bleeding.

    (Friedman RK, Heath AS, Huffman JE, Baker JT, Hasbani NR, Gagliano Taliun SA, Chen MH, Howard TE, Lewis JP, Pankratz N, Patil S, Reiner AP, Thibord F, Yanek LR, Yao J, Chen HH, Curran JE, Faraday N, Guo X, Wheeler MM, Ryan KA, Zhou X, Cho K, Almasy L, Auer PL, Becker LC, Wilson PWF, Boerwinkle E, O'Connell JR, Rich SS, Samuels DC, National Heart, Lung and Blood Institute (NHLBI) Trans-Omics for Precision Medicine (TOPMed) Consortium, TOPMed Hematology & Hemostasis Working Group, VA Million Veteran Program, Blangero J, Fornage M, Kooperberg C, Mathias RA, Mitchell BD, Rotter JI, Johnson AD, Smith NL, Coban-Akdemir ZH, Below JE, Morrison AC, Johnsen JM, de Vries PS.) J Thromb Haemost. 2025 Aug;23(8):2410-2421 PMID: 40368142 05/15/2025

  • Mosaic Loss of Y chromosome associates with lung function, emphysema and epigenetic aging.

    (Saw WY, Kim K, Huang Y, Yun JH, Ma X, Bacon J, Pershad Y, Levy D, O'Connor GT, Boerwinkle E, Barr RG, Rich SS, Rotter JI, Carson AP, Raffield LM, Gharib SA, Bartz TM, Psaty BM, Sofer T, North KE, Kaplan R, Oelsner EC, Manichaikul A, Bick AG, Sheet P, Reiner AP, NHLBI Trans-Omics for Precision Medicine Consortium, Jakubek YA, Auer PL, Cho MH, DeMeo DL.) medRxiv. 2025 Jul 30 PMID: 40766134 PMCID: PMC12324632 08/06/2025

  • CYTO-SV-ML: A Machine Learning Tool for Cytogenetic Structural Variant Analysis in Somatic Cell Type Using Genome Sequences.

    (Zhang T, Auer P, Spellman SR, Dong J, Saber W, Bolon YT.) Life (Basel). 2025 Jun 09;15(6) PMID: 40566581 PMCID: PMC12194788 06/26/2025

  • Analysis of more than 400,000 women provides case-control evidence for BRCA1 and BRCA2 variant classification.

    (Zanti M, O'Mahony DG, Parsons MT, Dorling L, Dennis J, Boddicker NJ, Chen W, Hu C, Naven M, Yiangou K, Ahearn TU, Ambrosone CB, Andrulis IL, Antoniou AC, Auer PL, Baynes C, Bodelon C, Bogdanova NV, Bojesen SE, Bolla MK, Brantley KD, Camp NJ, Campbell A, Castelao JE, Cessna MH, Chang-Claude J, Chen F, Chenevix-Trench G, NBCS Collaborators, Conroy DM, Czene K, De Nicolo A, Domchek SM, Dörk T, Dunning AM, Eliassen AH, Evans DG, Fasching PA, Figueroa JD, Flyger H, Gago-Dominguez M, García-Closas M, Glendon G, González-Neira A, Grassmann F, Hadjisavvas A, Haiman CA, Hamann U, Hart SN, Hartman MBA, Ho WK, Hodge JM, Hoppe R, Howell SJ, kConFab Investigators, Jakubowska A, Khusnutdinova EK, Ko YD, Kraft P, Kristensen VN, Lacey JV, Li J, Lim GH, Lindström S, Lophatananon A, Luccarini C, Mannermaa A, Martinez ME, Mavroudis D, Milne RL, Muir K, Nathanson KL, Nuñez-Torres R, Obi N, Olson JE, Palmer JR, Panayiotidis MI, Patel AV, Pharoah PDP, Polley EC, Rashid MU, Ruddy KJ, Saloustros E, Sawyer EJ, Schmidt MK, Southey MC, Tan VK, Teo SH, Teras LR, Torres D, Trentham-Dietz A, Truong T, Vachon CM, Wang Q, Weitzel JN, Yadav S, Yao S, Zirpoli GR, Cline MS, Devilee P, Tavtigian SV, Goldgar DE, Couch FJ, Easton DF, Spurdle AB, Michailidou K.) Nat Commun. 2025 May 25;16(1):4852 PMID: 40413188 PMCID: PMC12103537 05/25/2025

  • Early life trauma patterns and adult epigenome-wide and NR3C1-specific DNA methylation in the Sister Study.

    (Woo JMP, Lawrence KG, Xu Z, Auer PL, Simanek AM, Konkel RH, Taylor JA, Meier HCS, Sandler DP.) Am J Epidemiol. 2025 Apr 11 PMID: 40233982 04/16/2025

Publications of Paul L. Auer PhD from the Faculty Collaboration Database

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