Peter LaViolette, PhD | Associate Professor | Medical College of Wisconsin

Peter S. LaViolette, PhD, MS

Associate Professor; Director, Quantitative Imaging Laboratory, Medical College of Wisconsin; Section of Imaging Research, Division of Imaging Sciences

Locations

Medical College of Wisconsin
Department of Radiology

Contact Information

Education

Postdoctoral Fellowship, Medical College of Wisconsin, Milwaukee, WI, 2011-2012
PhD, Biophysics, Medical College of Wisconsin, Milwaukee, WI, 2011
MA, MS, Physics, University of Massachusetts, Amherst, MA, 2005
BS, Physics, St. Norbert College, De Pere, WI, 2003

Research Interests

The overall goal of my lab’s research is creating and validating imaging techniques that improve both patient outcome and treatment efficacy. I primarily work with neurological diseases such as brain cancer and epilepsy in a translational setting, collaborating with clinicians for the betterment of patient care.

Our brain cancer research has been focused on characterizing brain tumor cellularity and vascularity through imaging methods such as diffusion and perfusion MRI. The neuro-imaging techniques we develop are used to determine whether brain tumors respond to therapy or signal when brain tumors are progressing. In addition to patient outcome studies, we study the histological features responsible for the imaging characteristics measures in-vivo. This provides us with a validation technique for assessing our imaging biomarkers.

My epilepsy research is mainly focused on development of image processing techniques meant to help clinicians better plan surgery and map out brain function.

Multi-Site Concordance of Diffusion-Weighted Imaging Quantification for Assessing Prostate Cancer Aggressiveness.

(McGarry SD, Brehler M, Bukowy JD, Lowman AK, Bobholz SA, Duenweg SR, Banerjee A, Hurrell SL, Malyarenko D, Chenevert TL, Cao Y, Li Y, You D, Fedorov A, Bell LC, Quarles CC, Prah MA, Schmainda KM, Taouli B, LoCastro E, Mazaheri Y, Shukla-Dave A, Yankeelov TE, Hormuth DA 2nd, Madhuranthakam AJ, Hulsey K, Li K, Huang W, Huang W, Muzi M, Jacobs MA, Solaiyappan M, Hectors S, Antic T, Paner GP, Palangmonthip W, Jacobsohn K, Hohenwalter M, Duvnjak P, Griffin M, See W, Nevalainen MT, Iczkowski KA, LaViolette PS.) J Magn Reson Imaging. 2022 06;55(6):1745-1758 PMID: 34767682 PMCID: PMC9095769 SCOPUS ID: 2-s2.0-85118887092 11/13/2021
Radio-Pathomic Maps of Cell Density Identify Brain Tumor Invasion beyond Traditional MRI-Defined Margins.

(Bobholz SA, Lowman AK, Brehler M, Kyereme F, Duenweg SR, Sherman J, McGarry SD, Cochran EJ, Connelly J, Mueller WM, Agarwal M, Banerjee A, LaViolette PS.) AJNR Am J Neuroradiol. 2022 May;43(5):682-688 PMID: 35422419 PMCID: PMC9089258 04/16/2022
Image Quality Evaluation in Dual-Energy CT of the Chest, Abdomen, and Pelvis in Obese Patients With Deep Learning Image Reconstruction.

(Fair E, Profio M, Kulkarni N, Laviolette PS, Barnes B, Bobholz S, Levenhagen M, Ausman R, Griffin MO, Duvnjak P, Zorn AP, Foley WD.) J Comput Assist Tomogr. 2022 Apr 27 PMID: 35483100 04/29/2022
The impeded diffusion fraction quantitative imaging assay demonstrated in multi-exponential diffusion phantom and prostate cancer.

(Malyarenko DI, Swanson SD, McGarry SD, LaViolette PS, Chenevert TL.) Magn Reson Med. 2022 04;87(4):2053-2062 PMID: 34775621 PMCID: PMC8810585 11/15/2021
Tumor Connectomics: Mapping the Intra-Tumoral Complex Interaction Network Using Machine Learning.

(Parekh VS, Pillai JJ, Macura KJ, LaViolette PS, Jacobs MA.) Cancers (Basel). 2022 Mar 14;14(6) PMID: 35326634 PMCID: PMC8946165 03/26/2022
Diffusion Restriction Comparison between Gleason 4 Fused Glands and Cribriform Glands within Patient Using Whole-Mount Prostate Pathology as Ground Truth.

(Duenweg SR, Fang X, Bobholz SA, Lowman AK, Brehler M, Kyereme F, Iczkowski KA, Jacobsohn KM, Banerjee A, LaViolette PS.) Tomography. 2022 03 02;8(2):635-643 PMID: 35314630 PMCID: PMC8938782 SCOPUS ID: 2-s2.0-85125945301 03/23/2022
Second-Generation Jak2 Inhibitors for Advanced Prostate Cancer: Are We Ready for Clinical Development?

(Beinhoff P, Sabharwal L, Udhane V, Maranto C, LaViolette PS, Jacobsohn KM, Tsai S, Iczkowski KA, Wang L, Hall WA, Dehm SM, Kilari D, Nevalainen MT.) Cancers (Basel). 2021 Oct 17;13(20) PMID: 34680353 PMCID: PMC8533841 10/24/2021
Cardiac Magnetic Resonance for Early Detection of Radiation Therapy-Induced Cardiotoxicity in a Small Animal Model.

(Ibrahim EH, Baruah D, Croisille P, Stojanovska J, Rubenstein JC, Frei A, Schlaak RA, Lin CY, Pipke JL, Lemke A, Xu Z, Klaas A, Brehler M, Flister MJ, Laviolette PS, Gore EM, Bergom C.) JACC CardioOncol. 2021 Mar;3(1):113-130 PMID: 33912843 PMCID: PMC8078846 04/30/2021
Kcnj16 knockout produces audiogenic seizures in the Dahl salt-sensitive rat.

(Manis AD, Palygin O, Isaeva E, Levchenko V, LaViolette PS, Pavlov TS, Hodges MR, Staruschenko A.) JCI Insight. 2021 01 11;6(1) PMID: 33232300 PMCID: PMC7821607 SCOPUS ID: 2-s2.0-85099291307 11/25/2020
Prospects for Clinical Development of Stat5 Inhibitor IST5-002: High Transcriptomic Specificity in Prostate Cancer and Low Toxicity In Vivo.

(Maranto C, Udhane V, Jia J, Verma R, Müller-Newen G, LaViolette PS, Pereckas M, Sabharwal L, Terhune S, Pattabiraman N, Njar VCO, Imig JD, Wang L, Nevalainen MT.) Cancers (Basel). 2020 Nov 18;12(11) PMID: 33217941 PMCID: PMC7724566 SCOPUS ID: 2-s2.0-85096199725 11/22/2020
Accurate segmentation of prostate cancer histomorphometric features using a weakly supervised convolutional neural network.

(Bukowy JD, Foss H, McGarry SD, Lowman AK, Hurrell SL, Iczkowski KA, Banerjee A, Bobholz SA, Barrington A, Dayton A, Unteriner J, Jacobsohn K, See WA, Nevalainen MT, Nencka AS, Ethridge T, Jarrard DF, LaViolette PS.) J Med Imaging (Bellingham). 2020 Sep;7(5):057501 PMID: 33062803 PMCID: PMC7550797 10/17/2020
Radio-pathomic mapping model generated using annotations from five pathologists reliably distinguishes high-grade prostate cancer.

(McGarry SD, Bukowy JD, Iczkowski KA, Lowman AK, Brehler M, Bobholz S, Nencka A, Barrington A, Jacobsohn K, Unteriner J, Duvnjak P, Griffin M, Hohenwalter M, Keuter T, Huang W, Antic T, Paner G, Palangmonthip W, Banerjee A, LaViolette PS.) J Med Imaging (Bellingham). 2020 Sep;7(5):054501 PMID: 32923510 PMCID: PMC7479263 SCOPUS ID: 2-s2.0-85096616055 09/15/2020

Peter LaViolette, PhD, MS