Peter LaViolette, PhD | Associate Professor | Medical College of Wisconsin

Peter S. LaViolette, PhD, MS

Associate Professor of Radiology and Biomedical Engineering; Director, Quantitative Imaging Laboratory, Medical College of Wisconsin; Section of Imaging Research, Division of Imaging Sciences

Locations

Medical College of Wisconsin
Department of Radiology

Contact Information

Education

Postdoctoral Fellowship, Medical College of Wisconsin, Milwaukee, WI, 2011-2012
PhD, Biophysics, Medical College of Wisconsin, Milwaukee, WI, 2011
MA, MS, Physics, University of Massachusetts, Amherst, MA, 2005
BS, Physics, St. Norbert College, De Pere, WI, 2003

Research Interests

The overall goal of my lab’s research is creating and validating imaging techniques that improve both patient outcome and treatment efficacy. I primarily work with neurological diseases such as brain cancer and epilepsy in a translational setting, collaborating with clinicians for the betterment of patient care.

Our brain cancer research has been focused on characterizing brain tumor cellularity and vascularity through imaging methods such as diffusion and perfusion MRI. The neuro-imaging techniques we develop are used to determine whether brain tumors respond to therapy or signal when brain tumors are progressing. In addition to patient outcome studies, we study the histological features responsible for the imaging characteristics measures in-vivo. This provides us with a validation technique for assessing our imaging biomarkers.

My epilepsy research is mainly focused on development of image processing techniques meant to help clinicians better plan surgery and map out brain function.

Accurate segmentation of prostate cancer histomorphometric features using a weakly supervised convolutional neural network.

(Bukowy JD, Foss H, McGarry SD, Lowman AK, Hurrell SL, Iczkowski KA, Banerjee A, Bobholz SA, Barrington A, Dayton A, Unteriner J, Jacobsohn K, See WA, Nevalainen MT, Nencka AS, Ethridge T, Jarrard DF, LaViolette PS.) J Med Imaging (Bellingham). 2020 Sep;7(5):057501 PMID: 33062803 PMCID: PMC7550797 10/17/2020
Radio-pathomic mapping model generated using annotations from five pathologists reliably distinguishes high-grade prostate cancer.

(McGarry SD, Bukowy JD, Iczkowski KA, Lowman AK, Brehler M, Bobholz S, Nencka A, Barrington A, Jacobsohn K, Unteriner J, Duvnjak P, Griffin M, Hohenwalter M, Keuter T, Huang W, Antic T, Paner G, Palangmonthip W, Banerjee A, LaViolette PS.) J Med Imaging (Bellingham). 2020 Sep;7(5):054501 PMID: 32923510 PMCID: PMC7479263 SCOPUS ID: 2-s2.0-85096616055 09/15/2020
Radiomic Features of Multiparametric MRI Present Stable Associations With Analogous Histological Features in Patients With Brain Cancer.

(Bobholz SA, Lowman AK, Barrington A, Brehler M, McGarry S, Cochran EJ, Connelly J, Mueller WM, Agarwal M, O'Neill D, Nencka AS, Banerjee A, LaViolette PS.) Tomography. 2020 06;6(2):160-169 PMID: 32548292 PMCID: PMC7289245 SCOPUS ID: 2-s2.0-85086686895 06/18/2020
Corpora amylacea in benign prostatic acini are associated with concurrent, predominantly low-grade cancer.

(Palangmonthip W, Wu R, Tarima S, Bobholz SA, LaViolette PS, Gallan AJ, Iczkowski KA.) Prostate. 2020 06;80(9):687-697 PMID: 32271960 SCOPUS ID: 2-s2.0-85083052266 04/10/2020
Longitudinal molecular trajectories of diffuse glioma in adults.

(Barthel FP, Johnson KC, Varn FS, Moskalik AD, Tanner G, Kocakavuk E, Anderson KJ, Abiola O, Aldape K, Alfaro KD, Alpar D, Amin SB, Ashley DM, Bandopadhayay P, Barnholtz-Sloan JS, Beroukhim R, Bock C, Brastianos PK, Brat DJ, Brodbelt AR, Bruns AF, Bulsara KR, Chakrabarty A, Chakravarti A, Chuang JH, Claus EB, Cochran EJ, Connelly J, Costello JF, Finocchiaro G, Fletcher MN, French PJ, Gan HK, Gilbert MR, Gould PV, Grimmer MR, Iavarone A, Ismail A, Jenkinson MD, Khasraw M, Kim H, Kouwenhoven MCM, LaViolette PS, Li M, Lichter P, Ligon KL, Lowman AK, Malta TM, Mazor T, McDonald KL, Molinaro AM, Nam DH, Nayyar N, Ng HK, Ngan CY, Niclou SP, Niers JM, Noushmehr H, Noorbakhsh J, Ormond DR, Park CK, Poisson LM, Rabadan R, Radlwimmer B, Rao G, Reifenberger G, Sa JK, Schuster M, Shaw BL, Short SC, Smitt PAS, Sloan AE, Smits M, Suzuki H, Tabatabai G, Van Meir EG, Watts C, Weller M, Wesseling P, Westerman BA, Widhalm G, Woehrer A, Yung WKA, Zadeh G, Huse JT, De Groot JF, Stead LF, Verhaak RGW, GLASS Consortium.) Nature. 2019 12;576(7785):112-120 PMID: 31748746 PMCID: PMC6897368 SCOPUS ID: 2-s2.0-85075234677 11/22/2019
Positive STAT5 Protein and Locus Amplification Status Predicts Recurrence after Radical Prostatectomy to Assist Clinical Precision Management of Prostate Cancer.

(Haddad BR, Erickson A, Udhane V, LaViolette PS, Rone JD, Kallajoki MA, See WA, Rannikko A, Mirtti T, Nevalainen MT.) Cancer Epidemiol Biomarkers Prev. 2019 10;28(10):1642-1651 PMID: 31292140 PMCID: PMC6774884 SCOPUS ID: 2-s2.0-85072849403 07/12/2019
Gleason Probability Maps: A Radiomics Tool for Mapping Prostate Cancer Likelihood in MRI Space.

(McGarry SD, Bukowy JD, Iczkowski KA, Unteriner JG, Duvnjak P, Lowman AK, Jacobsohn K, Hohenwalter M, Griffin MO, Barrington AW, Foss HE, Keuter T, Hurrell SL, See WA, Nevalainen MT, Banerjee A, LaViolette PS.) Tomography. 2019 03;5(1):127-134 PMID: 30854450 PMCID: PMC6403022 SCOPUS ID: 2-s2.0-85071529534 03/12/2019
The Impact of Arterial Input Function Determination Variations on Prostate Dynamic Contrast-Enhanced Magnetic Resonance Imaging Pharmacokinetic Modeling: A Multicenter Data Analysis Challenge, Part II.

(Huang W, Chen Y, Fedorov A, Li X, Jajamovich GH, Malyarenko DI, Aryal MP, LaViolette PS, Oborski MJ, O'Sullivan F, Abramson RG, Jafari-Khouzani K, Afzal A, Tudorica A, Moloney B, Gupta SN, Besa C, Kalpathy-Cramer J, Mountz JM, Laymon CM, Muzi M, Kinahan PE, Schmainda K, Cao Y, Chenevert TL, Taouli B, Yankeelov TE, Fennessy F, Li X.) Tomography. 2019 03;5(1):99-109 PMID: 30854447 PMCID: PMC6403046 SCOPUS ID: 2-s2.0-85069224523 03/12/2019
An integrated iterative annotation technique for easing neural network training in medical image analysis.

(Lutnick B, Ginley B, Govind D, McGarry SD, LaViolette PS, Yacoub R, Jain S, Tomaszewski JE, Jen KY, Sarder P.) Nat Mach Intell. 2019 Feb;1(2):112-119 PMID: 31187088 PMCID: PMC6557463 06/13/2019
Radio-pathomic Maps of Epithelium and Lumen Density Predict the Location of High-Grade Prostate Cancer.

(McGarry SD, Hurrell SL, Iczkowski KA, Hall W, Kaczmarowski AL, Banerjee A, Keuter T, Jacobsohn K, Bukowy JD, Nevalainen MT, Hohenwalter MD, See WA, LaViolette PS.) Int J Radiat Oncol Biol Phys. 2018 08 01;101(5):1179-1187 PMID: 29908785 PMCID: PMC6190585 SCOPUS ID: 2-s2.0-85048748761 06/18/2018
Vascular Interventional Radiology-Guided Photothermal Therapy of Colorectal Cancer Liver Metastasis with Theranostic Gold Nanorods.

(Parchur AK, Sharma G, Jagtap JM, Gogineni VR, LaViolette PS, Flister MJ, White SB, Joshi A.) ACS Nano. 2018 07 24;12(7):6597-6611 PMID: 29969226 07/04/2018
Split laminotomy versus conventional laminotomy: postoperative outcomes in pediatric patients.

(Arocho-Quinones EV, Kolimas A, LaViolette PS, Kaufman BA, Foy AB, Zwienenberg M, Lew SM.) J Neurosurg Pediatr. 2018 06;21(6):615-625 PMID: 29570034 03/24/2018

Peter LaViolette, PhD, MS