Peter LaViolette, PhD, MS

Peter S. LaViolette, PhD, MS

Associate Professor of Radiology and Biomedical Engineering; Director, Quantitative Imaging Laboratory, Medical College of Wisconsin; Section of Imaging Research, Division of Imaging Sciences

Locations

Medical College of Wisconsin
Department of Radiology

Contact Information

Biography

Education

Postdoctoral Fellowship, Medical College of Wisconsin, Milwaukee, WI, 2011-2012
PhD, Biophysics, Medical College of Wisconsin, Milwaukee, WI, 2011
MA, MS, Physics, University of Massachusetts, Amherst, MA, 2005
BS, Physics, St. Norbert College, De Pere, WI, 2003

Research Interests

The overall goal of my lab’s research is creating and validating imaging techniques that improve both patient outcome and treatment efficacy. I primarily work with neurological diseases such as brain cancer and epilepsy in a translational setting, collaborating with clinicians for the betterment of patient care.

Our brain cancer research has been focused on characterizing brain tumor cellularity and vascularity through imaging methods such as diffusion and perfusion MRI. The neuro-imaging techniques we develop are used to determine whether brain tumors respond to therapy or signal when brain tumors are progressing. In addition to patient outcome studies, we study the histological features responsible for the imaging characteristics measures in-vivo. This provides us with a validation technique for assessing our imaging biomarkers.

My epilepsy research is mainly focused on development of image processing techniques meant to help clinicians better plan surgery and map out brain function.

Vascular Interventional Radiology-Guided Photothermal Therapy of Colorectal Cancer Liver Metastasis with Theranostic Gold Nanorods.

(Parchur AK, Sharma G, Jagtap JM, Gogineni VR, LaViolette PS, Flister MJ, White SB, Joshi A.) ACS Nano. 2018 Jul 24;12(7):6597-6611.
Radio-pathomic Maps of Epithelium and Lumen Density Predict the Location of High-Grade Prostate Cancer.

(McGarry SD, Hurrell SL, Iczkowski KA, Hall W, Kaczmarowski AL, Banerjee A, Keuter T, Jacobsohn K, Bukowy JD, Nevalainen MT, Hohenwalter MD, See WA, LaViolette PS.) Int J Radiat Oncol Biol Phys. 2018 Aug 01;101(5):1179-1187.
Split laminotomy versus conventional laminotomy: postoperative outcomes in pediatric patients.

(Arocho-Quinones EV, Kolimas A, LaViolette PS, Kaufman BA, Foy AB, Zwienenberg M, Lew SM.) J Neurosurg Pediatr. 2018 Jun;21(6):615-625.
Optimized -value selection for the discrimination of prostate cancer grades, including the cribriform pattern, using diffusion weighted imaging.

(Hurrell SL, McGarry SD, Kaczmarowski A, Iczkowski KA, Jacobsohn K, Hohenwalter MD, Hall WA, See WA, Banerjee A, Charles DK, Nevalainen MT, Mackinnon AC, LaViolette PS.) J Med Imaging (Bellingham). 2018 01;5(1):011004.
Host genetic modifiers of nonproductive angiogenesis inhibit breast cancer.

(Flister MJ, Tsaih SW, Stoddard A, Plasterer C, Jagtap J, Parchur AK, Sharma G, Prisco AR, Lemke A, Murphy D, Al-Gizawiy M, Straza M, Ran S, Geurts AM, Dwinell MR, Greene AS, Bergom C, LaViolette PS, Joshi A.) Breast Cancer Res Treat. 2017 Aug;165(1):53-64.
Magnetic Resonance Imaging-Based Radiomic Profiles Predict Patient Prognosis in Newly Diagnosed Glioblastoma Before Therapy.

(McGarry SD, Hurrell SL, Kaczmarowski AL, Cochran EJ, Connelly J, Rand SD, Schmainda KM, LaViolette PS.) Tomography. 2016 Sep;2(3):223-228.
Progressing Bevacizumab-Induced Diffusion Restriction Is Associated with Coagulative Necrosis Surrounded by Viable Tumor and Decreased Overall Survival in Patients with Recurrent Glioblastoma.

(Nguyen HS, Milbach N, Hurrell SL, Cochran E, Connelly J, Bovi JA, Schultz CJ, Mueller WM, Rand SD, Schmainda KM, LaViolette PS.) AJNR Am J Neuroradiol. 2016 12;37(12):2201-2208.
The Impact of Arterial Input Function Determination Variations on Prostate Dynamic Contrast-Enhanced Magnetic Resonance Imaging Pharmacokinetic Modeling: A Multicenter Data Analysis Challenge.

(Huang W, Chen Y, Fedorov A, Li X, Jajamovich GH, Malyarenko DI, Aryal MP, LaViolette PS, Oborski MJ, O'Sullivan F, Abramson RG, Jafari-Khouzani K, Afzal A, Tudorica A, Moloney B, Gupta SN, Besa C, Kalpathy-Cramer J, Mountz JM, Laymon CM, Muzi M, Schmainda K, Cao Y, Chenevert TL, Taouli B, Yankeelov TE, Fennessy F, Li X.) Tomography. 2016 Mar;2(1):56-66.
Location of brain tumor intersecting white matter tracts predicts patient prognosis.

(Mickevicius NJ, Carle AB, Bluemel T, Santarriaga S, Schloemer F, Shumate D, Connelly J, Schmainda KM, LaViolette PS.) J Neurooncol. 2015 Nov;125(2):393-400.
Photodynamic therapy (PDT) for malignant brain tumors--where do we stand?

(Quirk BJ, Brandal G, Donlon S, Vera JC, Mang TS, Foy AB, Lew SM, Girotti AW, Jogal S, LaViolette PS, Connelly JM, Whelan HT.) Photodiagnosis Photodyn Ther. 2015 Sep;12(3):530-44.
Evaluation of pre-radiotherapy apparent diffusion coefficient (ADC): patterns of recurrence and survival outcomes analysis in patients treated for glioblastoma multiforme.

(Elson A, Paulson E, Bovi J, Siker M, Schultz C, Laviolette PS.) J Neurooncol. 2015 May;123(1):179-88.
CXM: a new tool for mapping breast cancer risk in the tumor microenvironment.

(Flister MJ, Endres BT, Rudemiller N, Sarkis AB, Santarriaga S, Roy I, Lemke A, Geurts AM, Moreno C, Ran S, Tsaih SW, De Pons J, Carlson DF, Tan W, Fahrenkrug SC, Lazarova Z, Lazar J, North PE, LaViolette PS, Dwinell MB, Shull JD, Jacob HJ.) Cancer Res. 2014 Nov 15;74(22):6419-29.