Ross Collery, PhD
Assistant Professor of Ophthalmology & Visual Sciences Assistant Professor of Cell Biology, Neurobiology and Anatomy
- Medical College of Wisconsin Eye Institute
- 925 N. 87 St. Room 827
Milwaukee, WI 53226
MSc, Molecular Genetics, Trinity College, Dublin, Ireland
PhD, Conway Institute of Biomolecular and Biomedical Research, University College Dublin, Ireland
Dr. Collery received his Bachelor of Science (specializing in Genetics) from Trinity College Dublin in 2000 and received his master’s degree in genetics from the same institution in 2003.
Dr. Collery then went on to obtain his PhD in Genetics from University College Dublin in 2008, where his research with Dr. Breandán Kennedy focused on using zebrafish to study both phototransduction in the eye, as well as the visual cycle. During his graduate career, he helped to characterize components of the cone and rod visual cycles, as well as applying emerging transgenic methods to express human proteins in zebrafish photoreceptors.
During his postdoctoral career, he worked with Dr. Brian Link at MCW studying the effects of BMP signaling and LRP2 function on eye size and refractive error.
Today, Dr. Collery continues to study pathways in the eye that contribute to vision, refractive error and retinoid trafficking.
Dr. Collery became a faculty member at the Medical College of Wisconsin Eye Institute in 2016.
The Collery lab studies studies refractive error and retinal degeneration in the eye, and how they influence one another, often having a common genetic cause.
Refractive error is common in inherited retinal degenerations, and conversely, refractive error can lead to retinal damage and degeneration.
We are especially interested in retinoids, compounds derived from vitamin A, that control many functions of the eye. Mutations in retinoid transport proteins have been shown to cause refractive error and photoreceptor loss. For example, mutations in human STRA6, a retinoid receptor found on the retinal pigment epithelial layer, cause Matthew-Wood syndrome, characterized by microphthalmia and coloboma.
To better understand how retinoids influence the development and health of the eye, we use a host of cutting-edge techniques, including:
- CRISPR/Cas9 genomic editing (Figure 1)
- Live imaging of the eye and retina using optical coherence tomography (OCT) (Figure 2)
- Refractive error measurement (Figure 3)
- Transgenic animal models (Figure 4; Movie 1)
- Fluorescent protein imaging (Figure 4)
- RNAseq transcriptomic profiling
(Ferre-Fernández JJ, Sorokina EA, Thompson S, Collery RF, Nordquist E, Lincoln J, Semina EV.) Hum Mol Genet. 2020 Sep 29;29(16):2723-2735 PMID: 32720677 PMCID: PMC7530528 SCOPUS ID: 2-s2.0-85092681312 07/29/2020
(Huckenpahler AL, Lookfong NA, Warr E, Heffernan E, Carroll J, Collery RF.) Transl Vis Sci Technol. 2020 09;9(10):18 PMID: 32983626 PMCID: PMC7500127 SCOPUS ID: 2-s2.0-85091664660 09/29/2020
(Collery RF, Link BA.) Front Cell Dev Biol. 2019;7:167 PMID: 31457013 PMCID: PMC6700241 SCOPUS ID: 2-s2.0-85072723134 08/29/2019
(Hanovice NJ, Leach LL, Slater K, Gabriel AE, Romanovicz D, Shao E, Collery R, Burton EA, Lathrop KL, Link BA, Gross JM.) PLoS Genet. 2019 01;15(1):e1007939 PMID: 30695061 PMCID: PMC6368336 SCOPUS ID: 2-s2.0-85061272556 01/30/2019
(Lapierre-Landry M, Huckenpahler AL, Link BA, Collery RF, Carroll J, Skala MC.) Transl Vis Sci Technol. 2018;7(5):4 PMID: 30197836 PMCID: PMC6126953 09/11/2018
(Daly C, Ward R, Reynolds AL, Galvin O, Collery RF, Kennedy BN.) Adv Exp Med Biol. 2018;1074:465-471 PMID: 29721977 SCOPUS ID: 2-s2.0-85046643012 05/04/2018
(Huckenpahler A, Wilk M, Link B, Carroll J, Collery R.) Adv Exp Med Biol. 2018;1074:151-156 PMID: 29721939 PMCID: PMC6363109 SCOPUS ID: 2-s2.0-85046645800 05/04/2018
(Wilk MA, Huckenpahler AL, Collery RF, Link BA, Carroll J.) Transl Vis Sci Technol. 2017 Apr;6(2):8 PMID: 28392975 PMCID: PMC5381330 04/11/2017
(Huckenpahler AL, Wilk MA, Cooper RF, Moehring F, Link BA, Carroll J, Collery RF.) Vis Neurosci. 2017 01;34:E005 PMID: 28965523 SCOPUS ID: 2-s2.0-85057402023 10/03/2017
(Collery RF, Volberding PJ, Bostrom JR, Link BA, Besharse JC.) Invest Ophthalmol Vis Sci. 2016 12 01;57(15):6805-6814 PMID: 28002843 PMCID: PMC5215506 SCOPUS ID: 2-s2.0-85007349845 12/22/2016
(Huckenpahler AL, Wilk MA, Cooper RF, Moehring F, Link BA, Carroll J, Collery RF.) Vis Neurosci. 2016 01;33:E011 PMID: 28177275 PMCID: PMC5659228 SCOPUS ID: 2-s2.0-85020503535 02/09/2017
(Link BA, Collery RF.) Annu Rev Vis Sci. 2015 Nov 24;1:125-153 PMID: 28532376 11/24/2015