Weiguo Cui, PhD
Associate Investigator, Versiti Blood Research Institute; Associate Professor, Microbiology & Immunology
- Versiti Blood Research Institute (Immunology)
Blood Center of Wisconsin
Memory T cell Biology
During an acute viral or bacterial infection, naïve T cells can differentiate into multiple types of effector and memory T cells that help to mediate pathogen clearance and provide long-term protective immunity. The main goal of our research in the lab is to elucidate how TCR and cytokine signaling and their downstream transcriptional programs regulate pathogen-specific T cells to proliferate, differentiate into either short-lived effector cells or long-lived memory cells.
Activated T cells receive and integrate a myriad of signals from their microenvironment. These signals differ in type, quality, quantity and duration, and could have significant impact on T cell activation, differentiation and survival. One area of our research interest is to study how these different signals cooperate with each other to regulate T cell expansion and acquisition of their effector function, and concurrently differ in their activities to control the short- or long-term fate decision. We aim to further investigate where and when these signals are produced and emanated, which will help to better understand how the distinct cellular niches influence effector and memory T cell fate decision and functional maturation.
JAK-STAT pathways are the important mediators to transmit extracellular signals into transcriptional programs that ultimately regulate effector and memory T cell differentiation, survival and homeostasis. Our recent work has demonstrated that STAT4 and STAT3 largely promote distinct cell fate commitment, and terminal effector versus memory cells respectively. A major focus in the lab currently is to better define how these different STAT pathways act in a synergistic or divergent fashion to regulate both terminal cell-fate commitment and permit plasticity in effector and memory T cells.
(Zhu B, Wu Y, Huang S, Zhang R, Son YM, Li C, Cheon IS, Gao X, Wang M, Chen Y, Zhou X, Nguyen Q, Phan AT, Behl S, Taketo MM, Mack M, Shapiro VS, Zeng H, Ebihara H, Mullon JJ, Edell ES, Reisenauer JS, Demirel N, Kern RM, Chakraborty R, Cui W, Kaplan MH, Zhou X, Goldrath AW, Sun J.) Immunity. 2021 06 08;54(6):1200-1218.e9 PMID: 33951416 PMCID: PMC8192557 SCOPUS ID: 2-s2.0-85107318166 05/06/2021
(Stancill JS, Kasmani MY, Khatun A, Cui W, Corbett JA.) Life Sci Alliance. 2021 06;4(6) PMID: 33883217 PMCID: PMC8091599 SCOPUS ID: 2-s2.0-85105569108 04/23/2021
(Zhu W, Zheng Y, Yu M, Wei J, Zhang Y, Topchyan P, Nguyen C, Janecke R, Kreuziger LB, White GC, Hari P, Aster R, Cui W, Jobe S, Graham MB, Wang D, Wen R.) Res Sq. 2021 Apr 26 PMID: 34013243 PMCID: PMC8132233 05/21/2021
(Schauder DM, Shen J, Chen Y, Kasmani MY, Kudek MR, Burns R, Cui W.) Proc Natl Acad Sci U S A. 2021 Apr 20;118(16) PMID: 33859041 PMCID: PMC8072256 SCOPUS ID: 2-s2.0-85104381676 04/17/2021
(Jondle CN, Johnson KE, Aurubin C, Sylvester P, Xin G, Cui W, Huppler AR, Tarakanova VL.) mBio. 2021 04 06;12(2) PMID: 33824206 PMCID: PMC8092251 SCOPUS ID: 2-s2.0-85103513895 04/08/2021
(Xin G, Chen Y, Topchyan P, Kasmani MY, Burns R, Volberding PJ, Wu X, Cohn A, Chen Y, Lin CW, Ho PC, Silverstein R, Dwinell MB, Cui W.) Cancer Immunol Res. 2021 04;9(4):454-469 PMID: 33579728 PMCID: PMC8137571 SCOPUS ID: 2-s2.0-85104420312 02/14/2021
(Topchyan P, Xin G, Chen Y, Zheng S, Burns R, Shen J, Kasmani MY, Kudek M, Yang N, Cui W.) Cancers (Basel). 2021 Mar 12;13(6) PMID: 33809259 PMCID: PMC7998696 04/04/2021
(Khatun A, Kasmani MY, Zander R, Schauder DM, Snook JP, Shen J, Wu X, Burns R, Chen YG, Lin CW, Williams MA, Cui W.) J Exp Med. 2021 Mar 01;218(3) PMID: 33201171 PMCID: PMC7676493 SCOPUS ID: 2-s2.0-85096353007 11/18/2020
(Son YM, Cheon IS, Wu Y, Li C, Wang Z, Gao X, Chen Y, Takahashi Y, Fu YX, Dent AL, Kaplan MH, Taylor JJ, Cui W, Sun J.) Sci Immunol. 2021 Jan 08;6(55) PMID: 33419791 PMCID: PMC8056937 SCOPUS ID: 2-s2.0-85099721700 01/10/2021
(Topchyan P, Xin G, Chen Y, Zheng S, Burns R, Shen J, Kasmani MY, Kudek M, Yang N, Cui W.) Cancers. 2 March 2021;13(6):1-15 SCOPUS ID: 2-s2.0-85102393382 03/02/2021
(Cheng G, Hardy M, Topchyan P, Zander R, Volberding P, Cui W, Kalyanaraman B.) Sci Rep. 2020 10 21;10(1):17872 PMID: 33087770 PMCID: PMC7578061 SCOPUS ID: 2-s2.0-85093870747 10/23/2020
(Fu C, Peng P, Loschko J, Feng L, Pham P, Cui W, Lee KP, Krug AB, Jiang A.) Proc Natl Acad Sci U S A. 2020 09 22;117(38):23730-23741 PMID: 32879009 PMCID: PMC7519282 SCOPUS ID: 2-s2.0-85091571916 09/04/2020