Weiguo Cui, PhD
Associate Investigator, Versiti Blood Research Institute; Associate Professor, Microbiology & Immunology
- Versiti Blood Research Institute (Immunology)
Blood Center of Wisconsin
Memory T cell Biology
During an acute viral or bacterial infection, naïve T cells can differentiate into multiple types of effector and memory T cells that help to mediate pathogen clearance and provide long-term protective immunity. The main goal of our research in the lab is to elucidate how TCR and cytokine signaling and their downstream transcriptional programs regulate pathogen-specific T cells to proliferate, differentiate into either short-lived effector cells or long-lived memory cells.
Activated T cells receive and integrate a myriad of signals from their microenvironment. These signals differ in type, quality, quantity and duration, and could have significant impact on T cell activation, differentiation and survival. One area of our research interest is to study how these different signals cooperate with each other to regulate T cell expansion and acquisition of their effector function, and concurrently differ in their activities to control the short- or long-term fate decision. We aim to further investigate where and when these signals are produced and emanated, which will help to better understand how the distinct cellular niches influence effector and memory T cell fate decision and functional maturation.
JAK-STAT pathways are the important mediators to transmit extracellular signals into transcriptional programs that ultimately regulate effector and memory T cell differentiation, survival and homeostasis. Our recent work has demonstrated that STAT4 and STAT3 largely promote distinct cell fate commitment, and terminal effector versus memory cells respectively. A major focus in the lab currently is to better define how these different STAT pathways act in a synergistic or divergent fashion to regulate both terminal cell-fate commitment and permit plasticity in effector and memory T cells.
(Ciecko AE, Schauder DM, Foda B, Petrova G, Kasmani MY, Burns R, Lin CW, Drobyski WR, Cui W, Chen YG.) J Immunol. 2021 10 15;207(8):1990-2004 PMID: 34507949 PMCID: PMC8492517 SCOPUS ID: 2-s2.0-85116529072 09/12/2021
(Connolly KA, Kuchroo M, Venkat A, Khatun A, Wang J, William I, Hornick NI, Fitzgerald BL, Damo M, Kasmani MY, Cui C, Fagerberg E, Monroy I, Hutchins A, Cheung JF, Foster GG, Mariuzza DL, Nader M, Zhao H, Cui W, Krishnaswamy S, Joshi NS.) Sci Immunol. 2021 10;6(64):eabg7836 PMID: 34597124 PMCID: PMC8593910 SCOPUS ID: 2-s2.0-85116904335 10/02/2021
(Chen Y, Shen J, Kasmani MY, Topchyan P, Cui W.) Cells. 2021 08 20;10(8) PMID: 34440912 PMCID: PMC8392357 SCOPUS ID: 2-s2.0-85115043864 08/28/2021
(Kasmani MY, Cui W.) J Exp Med. 2021 08 02;218(8) PMID: 34132742 PMCID: PMC8212782 SCOPUS ID: 2-s2.0-85108144095 06/17/2021
(Chen Y, Zander RA, Wu X, Schauder DM, Kasmani MY, Shen J, Zheng S, Burns R, Taparowsky EJ, Cui W.) Nat Immunol. 2021 08;22(8):996-1007 PMID: 34282329 SCOPUS ID: 2-s2.0-85110654837 07/21/2021
(Pan J, Chen Y, Zhang Q, Khatun A, Palen K, Xin G, Wang L, Yang C, Johnson BD, Myers CR, Sei S, Shoemaker RH, Lubet RA, Wang Y, Cui W, You M.) Commun Biol. 2021 07 23;4(1):906 PMID: 34302042 PMCID: PMC8302676 SCOPUS ID: 2-s2.0-85111091265 07/25/2021
(Cheng G, Hardy M, Topchyan P, Zander R, Volberding P, Cui W, Kalyanaraman B.) iScience. 2021 Jun 25;24(6):102673 PMID: 34189437 PMCID: PMC8215227 07/01/2021
(Zhu B, Wu Y, Huang S, Zhang R, Son YM, Li C, Cheon IS, Gao X, Wang M, Chen Y, Zhou X, Nguyen Q, Phan AT, Behl S, Taketo MM, Mack M, Shapiro VS, Zeng H, Ebihara H, Mullon JJ, Edell ES, Reisenauer JS, Demirel N, Kern RM, Chakraborty R, Cui W, Kaplan MH, Zhou X, Goldrath AW, Sun J.) Immunity. 2021 06 08;54(6):1200-1218.e9 PMID: 33951416 PMCID: PMC8192557 SCOPUS ID: 2-s2.0-85107318166 05/06/2021
(Volberding PJ, Xin G, Kasmani MY, Khatun A, Brown AK, Nguyen C, Stancill JS, Martinez E, Corbett JA, Cui W.) Cell Rep. 2021 05 25;35(8):109160 PMID: 34038722 PMCID: PMC8182757 SCOPUS ID: 2-s2.0-85106489485 05/27/2021
(Zhu W, Zheng Y, Yu M, Wei J, Zhang Y, Topchyan P, Nguyen C, Janecke R, Kreuziger LB, White GC, Hari P, Aster R, Cui W, Jobe S, Graham MB, Wang D, Wen R.) Res Sq. 2021 Apr 26 PMID: 34013243 PMCID: PMC8132233 05/21/2021
(Chen Y, Zander RA, Wu X, Schauder DM, Kasmani MY, Shen J, Zheng S, Burns R, Taparowsky EJ, Cui W.) Nature Immunology. August 2021;22(8):996-1007 SCOPUS ID: 2-s2.0-85110654837 08/01/2021
(Kasmani MY, Cui W.) Journal of Experimental Medicine. 16 June 2021;218(8) SCOPUS ID: 2-s2.0-85108144095 06/16/2021