
Bin Pan, PhD
Associate Professor
Contact Information
Education
PhD, Xi'an Jiaotong University, China
Postdoctoral training, Neurology, University of California at Berkeley
Postdoctoral training, Neuropharmacology, Medical College of Wisconsin
Research Interests
- Mechanisms of neuropathic pain
- Chronic pain induced depression
Chronic pain is a major public health challenge that is inadequately addressed. The complexity of mechanisms underlying chronic pain includes not only a localized, peripheral disorder, but also widespread central nervous system dysfunction.
In the past, we found that:
- The extracellular matrix glycoprotein thrombospondin-4 is increased after nerve injury and this increased TSP4 can regulate voltage activated calcium channels and intracellular calcium signaling in dorsal root ganglion (DRG) neurons
- DRG field stimulation can relieve spontaneous and induced neuropathic pain in rats.
In the future, we will investigate changed synaptic transmission in spinal cord and cerebral cortex, which contribute to chronic pain.
Many patients with chronic pain conditions suffer from depression with a prevalence of suicidal ideation. The underlying mechanisms are still unknown. In this project, I will investigate synaptic mechanisms of chronic pain-induced depression with multiple techniques including behavioral tests, in vivo and in vitro brain slice neurophysiological recording, molecular analysis, and genetic engineering
Publications
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(Chao D, Tran H, Hogan QH, Pan B.) Osteoarthritis Cartilage. 2022 Nov;30(11):1468-1481 PMID: 36030058 PMCID: PMC9588581 SCOPUS ID: 2-s2.0-85137699296 08/28/2022
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(Yu G, Segel I, Tran H, Park HJ, Ross E, Hogan QH, Pan B.) Neuromodulation. 2022 Oct;25(7):970-979 PMID: 34096146 PMCID: PMC8645661 SCOPUS ID: 2-s2.0-85107189022 06/08/2021
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(Chao D, Mecca CM, Yu G, Segel I, Gold MS, Hogan QH, Pan B.) Pain. 2021 Dec 01;162(12):2917-2932 PMID: 33990112 PMCID: PMC8486885 SCOPUS ID: 2-s2.0-85122047046 05/15/2021
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(Mecca CM, Chao D, Yu G, Feng Y, Segel I, Zhang Z, Rodriguez-Garcia DM, Pawela CP, Hillard CJ, Hogan QH, Pan B.) J Neurosci. 2021 Sep 01;41(35):7492-7508 PMID: 34244365 PMCID: PMC8412994 SCOPUS ID: 2-s2.0-85114152937 07/11/2021
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Correction to: Genomic Action of Sigma-1 Receptor Chaperone Relates to Neuropathic Pain.
(Wang SM, Goguadze N, Kimura Y, Yasui Y, Pan B, Wang TY, Nakamura Y, Lin YT, Hogan QH, Wilson KL, Su TP, Wu HE.) Mol Neurobiol. 2021 Jun;58(6):2542 PMID: 33523359 PMCID: PMC8496664 SCOPUS ID: 2-s2.0-85100094553 02/02/2021
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Genomic Action of Sigma-1 Receptor Chaperone Relates to Neuropathic Pain.
(Wang SM, Goguadze N, Kimura Y, Yasui Y, Pan B, Wang TY, Nakamura Y, Lin YT, Hogan QH, Wilson KL, Su TP, Wu HE.) Mol Neurobiol. 2021 Jun;58(6):2523-2541 PMID: 33459966 PMCID: PMC8128747 SCOPUS ID: 2-s2.0-85100181606 01/19/2021
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(Feng Y, Li K, Roth E, Chao D, Mecca CM, Hogan QH, Pawela C, Kwok WM, Camara AKS, Pan B.) Front Cell Neurosci. 2021;15:689334 PMID: 34447298 PMCID: PMC8383341 SCOPUS ID: 2-s2.0-85113358817 08/28/2021
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(Chao D, Zhang Z, Mecca CM, Hogan QH, Pan B.) Pain. 2020 Dec;161(12):2872-2886 PMID: 32658148 PMCID: PMC7669706 SCOPUS ID: 2-s2.0-85096203014 07/14/2020
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(Yu G, Segel I, Zhang Z, Hogan QH, Pan B.) Anesthesiology. 2020 Aug;133(2):408-425 PMID: 32433276 PMCID: PMC8195267 SCOPUS ID: 2-s2.0-85088176994 05/21/2020
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(Shin SM, Itson-Zoske B, Cai Y, Qiu C, Pan B, Stucky CL, Hogan QH, Yu H.) Mol Pain. 2020;16:1744806920925425 PMID: 32484015 PMCID: PMC7268132 SCOPUS ID: 2-s2.0-85085909943 06/03/2020
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(Yu H, Shin SM, Xiang H, Chao D, Cai Y, Xu H, Khanna R, Pan B, Hogan QH.) Gene Ther. 2019 Aug;26(7-8):308-323 PMID: 31118475 PMCID: PMC6707887 SCOPUS ID: 2-s2.0-85066867179 05/24/2019
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(Pan B, Zhang Z, Chao D, Hogan QH.) Neuromodulation. 2018 Apr;21(3):247-253 PMID: 28872725 SCOPUS ID: 2-s2.0-85028826557 09/06/2017