
David Stowe, MD, PhD
Professor
Contact Information
Education
BA, Zoology, Indiana University - Bloomington, IN, 1968
MA, Cell Biology, Indiana University - Bloomington, IN, 1970
PhD, Physiology, Michigan State University - East Lansing, MI, 1974
Postdoc, Cardiac Physiology, University of California - San Francisco, CA, 1974–1976
MD, Medical College of Wisconsin - Milwaukee, WI, 1979-1983
Residency, Anesthesiology, Medical College of Wisconsin - Milwaukee, WI, 1983–1987
Research Interests
- Mechanisms for and protection against cardiac ischemia-reperfusion injury
- Identification and function of mitochondrial ion channels and ion exchangers
- Assessment of mitochondrial transmembrane calcium fluxes and sequestration
- Mitochondrial protection against subacute liver ischemia and traumatic brain injury
Publications
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(Gerdes HJ, Yang M, Heisner JS, Camara AKS, Stowe DF.) Biochim Biophys Acta Bioenerg. 2020 12 01;1861(12):148290 PMID: 32828729 PMCID: PMC7560995 SCOPUS ID: 2-s2.0-85089838074 08/24/2020
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(Riess ML, Elorbany R, Weihrauch D, Stowe DF, Camara AKS.) Cells. 2020 01 20;9(1) PMID: 31968546 PMCID: PMC7017211 SCOPUS ID: 2-s2.0-85099486696 01/24/2020
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(Mishra J, Davani AJ, Natarajan GK, Kwok WM, Stowe DF, Camara AKS.) Cells. 2019 09 07;8(9) PMID: 31500337 PMCID: PMC6770067 SCOPUS ID: 2-s2.0-85082240408 09/11/2019
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(Yang M, Xu Y, Heisner JS, Sun J, Stowe DF, Kwok WM, Camara AKS.) Mitochondrion. 2019 05;46:380-392 PMID: 30391711 PMCID: PMC6487210 SCOPUS ID: 2-s2.0-85056228802 11/06/2018
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Editorial: Genetic Modification of Cardiac Tissue.
(Camara AKS, Stowe DF, O-Uchi J, Bazil JN.) Front Cardiovasc Med. 2019;6:93 PMID: 31380395 PMCID: PMC6646414 08/06/2019
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(Haumann J, Camara AKS, Gadicherla AK, Navarro CD, Boelens AD, Blomeyer CA, Dash RK, Boswell MR, Kwok WM, Stowe DF.) Front Physiol. 2018;9:1914 PMID: 30804812 PMCID: PMC6378946 02/26/2019
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(Stowe DF, Yang M, Heisner JS, Camara AKS.) J Cardiovasc Pharmacol. 2017 Nov;70(5):314-328 PMID: 28777255 PMCID: PMC5726766 SCOPUS ID: 2-s2.0-85041528923 08/05/2017
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(Yang M, Camara AKS, Aldakkak M, Kwok WM, Stowe DF.) Biochim Biophys Acta Bioenerg. 2017 Jun;1858(6):442-458 PMID: 28342809 PMCID: PMC5749404 SCOPUS ID: 2-s2.0-85017126810 03/28/2017
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Single-lung ventilation and oxidative stress: a different perspective on a common practice.
(Heerdt PM, Stowe DF.) Curr Opin Anaesthesiol. 2017 Feb;30(1):42-49 PMID: 27783023 SCOPUS ID: 2-s2.0-84992428122 10/27/2016
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(Blomeyer CA, Bazil JN, Stowe DF, Dash RK, Camara AK.) J Bioenerg Biomembr. 2016 06;48(3):175-88 PMID: 26815005 PMCID: PMC5098337 SCOPUS ID: 2-s2.0-84955557614 01/28/2016
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(Rhodes SS, Camara AK, Aldakkak M, Heisner JS, Stowe DF.) Physiol Rep. 2015 Aug;3(8) PMID: 26290532 PMCID: PMC4562572 08/21/2015
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(Lindsay DP, Camara AK, Stowe DF, Lubbe R, Aldakkak M.) Front Physiol. 2015;6:58 PMID: 25805998 PMCID: PMC4354303 03/26/2015
The Stowe laboratory is currently active in several areas:
- Mechanism and timing of activation of cardiac mitochondrial small and large K+-sensitive Ca2+ (SKCa and BKCa) channels; their protective role against acute cardiac injury; identification of specific mitochondrial SKCa splice variants in several species, including human; and the molecular and biophysical mechanisms underlying protection by opening of these mitochondrial channels.
- Mitigation of Ca2+ dysregulation and excess reactive oxygen species emission in acute cardiac injury.
- Regulation of mitochondrial Ca2+ flux through Ca2+ channels and Ca2+ exchangers with H+, K+ and Na+; and exploration of dynamic mitochondrial Ca2+ buffering mechanisms.
- Ischemia-induced nitration of nucleotide transporters VDAC and ANT on promoting mitochondrial and cell damage with identification of specific residues that are causative in impeding nucleotide transport and mitochondrial dysfunction.
- Mitochondrial function in liver cells during the perioperative transplant period.
- Mitochondrial function in glial and neurons after subacute tramatic brain injury.
Collaborators include: AKS Camara, WM Kwok, C Pawela, A Geurts, J Hong, MY Yang, J Mishra, Q Cheng, L Keguo, JS Heisner, D Schwabe, and pre- and post doctoral students.