Hongxu Xian, PhD

Publications

• Self-amplifying NRF2-EZH2 epigenetic loop converts KRAS-initiated progenitors to invasive pancreatic cancer.

  (Antonucci L, Li N, Duran A, Cobo I, Nicoletti C, Watari K, Nandi SP, Zhu F, Zhao Y, Riahi I, Tsuda M, Shah VM, Morgan T, Waugh T, Caputo L, Liu Y, Rundberg Nilsson A, Xian H, Todoric J, Gu L, Sanchez-Lopez E, Eibl G, Vucic EA, Krawczyk M, Xu Q, Lowy AM, Hatzivassiliou G, Roose-Girma M, Skowronska-Krawczyk D, Scott DA, Bar-Sagi D, Tamayo P, Wu Y, Sears RC, Glass CK, Alexandrov LB, Puri PL, Dawson DW, Hu Y, Diaz-Meco MT, Moscat J, Karin M.) Nat Cancer. 2025 Jul;6(7):1263-1282 PMID: 40588523 PMCID: PMC12331375 07/01/2025

• Mitochondrial DNA oxidation propagates autoimmunity by enabling plasmacytoid dendritic cells to induce TFH differentiation.

  (Xian H, Watari K, Ohira M, Brito JS, He P, Onyuru J, Zuniga EI, Hoffman HM, Karin M.) Nat Immunol. 2025 Jul;26(7):1168-1181 PMID: 40528028 06/18/2025

• Death-Associated Protein 3 Triggers Intrinsic Apoptosis via Miro1 Upon Inducing Intracellular Calcium Changes.

  (Hu D, Yang Q, Xian H, Wang M, Zheng H, Mallilankaraman KB, Yu VC, Liou YC.) MedComm (2020). 2025 May;6(5):e70214 PMID: 40351389 PMCID: PMC12064944 05/12/2025

• IRF1 regulates self-renewal and stress-responsiveness to support hematopoietic stem cell maintenance.

  (Rundberg Nilsson A, Xian H, Shalapour S, Cammenga J, Karin M.) bioRxiv. 2023 Mar 02 PMID: 36747722 PMCID: PMC9900858 02/08/2023

• Oxidized mitochondrial DNA: a protective signal gone awry.

  (Xian H, Karin M.) Trends Immunol. 2023 Mar;44(3):188-200 PMID: 36739208 PMCID: PMC12045651 02/05/2023

• Oxidized DNA fragments exit mitochondria via mPTP- and VDAC-dependent channels to activate NLRP3 inflammasome and interferon signaling.

  (Xian H, Watari K, Sanchez-Lopez E, Offenberger J, Onyuru J, Sampath H, Ying W, Hoffman HM, Shadel GS, Karin M.) Immunity. 2022 Aug 09;55(8):1370-1385.e8 PMID: 35835107 PMCID: PMC9378606 07/15/2022

• Metformin inhibition of mitochondrial ATP and DNA synthesis abrogates NLRP3 inflammasome activation and pulmonary inflammation.

  (Xian H, Liu Y, Rundberg Nilsson A, Gatchalian R, Crother TR, Tourtellotte WG, Zhang Y, Aleman-Muench GR, Lewis G, Chen W, Kang S, Luevanos M, Trudler D, Lipton SA, Soroosh P, Teijaro J, de la Torre JC, Arditi M, Karin M, Sanchez-Lopez E.) Immunity. 2021 Jul 13;54(7):1463-1477.e11 PMID: 34115964 PMCID: PMC8189765 06/12/2021

• Functions of outer mitochondrial membrane proteins: mediating the crosstalk between mitochondrial dynamics and mitophagy.

  (Xian H, Liou YC.) Cell Death Differ. 2021 Mar;28(3):827-842 PMID: 33208889 PMCID: PMC7937681 11/20/2020

• Loss of MIEF1/MiD51 confers susceptibility to BAX-mediated cell death and PINK1-PRKN-dependent mitophagy.

  (Xian H, Liou YC.) Autophagy. 2019 Dec;15(12):2107-2125 PMID: 30894073 PMCID: PMC6844504 03/22/2019

• STX17 dynamically regulated by Fis1 induces mitophagy via hierarchical macroautophagic mechanism.

  (Xian H, Yang Q, Xiao L, Shen HM, Liou YC.) Nat Commun. 2019 May 03;10(1):2059 PMID: 31053718 PMCID: PMC6499814 05/06/2019

• Reactive oxygen species trigger Parkin/PINK1 pathway-dependent mitophagy by inducing mitochondrial recruitment of Parkin.

  (Xiao B, Goh JY, Xiao L, Xian H, Lim KL, Liou YC.) J Biol Chem. 2017 Oct 06;292(40):16697-16708 PMID: 28848050 PMCID: PMC5633131 08/30/2017

• Death-associated Protein 3 Regulates Mitochondrial-encoded Protein Synthesis and Mitochondrial Dynamics.

  (Xiao L, Xian H, Lee KY, Xiao B, Wang H, Yu F, Shen HM, Liou YC.) J Biol Chem. 2015 Oct 09;290(41):24961-74 PMID: 26306039 PMCID: PMC4599003 08/26/2015