Nicholas Jarjour, PhD

Publications

• Collaboration between interleukin-7 and -15 enables adaptation of tissue-resident and circulating memory CD8+ T cells to cytokine deficiency.

  (Jarjour NN, Dalzell TS, Maurice NJ, Wanhainen KM, Peng C, O'Flanagan SD, DePauw TA, Block KE, Valente WJ, Ashby KM, Masopust D, Jameson SC.) Immunity. 2025 Mar 11;58(3):616-631.e5 PMID: 40023156 03/03/2025

• Human ACE2 Gene Replacement Mice Support SARS-CoV-2 Viral Replication and Nonlethal Disease Progression.

  (Thiede JM, Dick JK, Jarjour NN, Krishna VD, Qian L, Sangala J, Benzow K, Karanjeet K, Chin S, Rainwater O, Cheeran MC, Hogquist KA, Jameson SC, Hart GT, Bold TD, Koob MD.) Immunohorizons. 2024 Sep 01;8(9):712-720 PMID: 39287601 PMCID: PMC11447706 09/17/2024

• Steady-state, therapeutic, and helminth-induced IL-4 compromise protective CD8 T cell bystander activation.

  (Maurice NJ, Dalzell TS, Jarjour NN, DePauw TA, Jameson SC.) bioRxiv. 2024 Jun 12 PMID: 38915668 PMCID: PMC11195063 06/25/2024

• Collaboration between IL-7 and IL-15 enables adaptation of tissue-resident and circulating memory CD8+ T cells.

  (Jarjour NN, Dalzell TS, Maurice NJ, Wanhainen KM, Peng C, DePauw TA, Block KE, Valente WJ, Ashby KM, Masopust D, Jameson SC.) bioRxiv. 2024 Jun 03 PMID: 38895229 PMCID: PMC11185530 06/19/2024

• BHLHE40 Mediates Cross-Talk between Pathogenic TH17 Cells and Myeloid Cells during Experimental Autoimmune Encephalomyelitis.

  (Cook ME, Shchukina I, Lin CC, Bradstreet TR, Schwarzkopf EA, Jarjour NN, Webber AM, Zaitsev K, Artyomov MN, Edelson BT.) Immunohorizons. 2023 Nov 01;7(11):737-746 PMID: 37934060 PMCID: PMC10695412 11/07/2023

• APLs and Oranges: Induction of T Cell Anergy by Altered Peptide Ligands.

  (Jarjour NN, Jameson SC.) J Immunol. 2023 Sep 01;211(5):709-710 PMID: 37603860 08/21/2023

• Responsiveness to interleukin-15 therapy is shared between tissue-resident and circulating memory CD8+ T cell subsets.

  (Jarjour NN, Wanhainen KM, Peng C, Gavil NV, Maurice NJ, Borges da Silva H, Martinez RJ, Dalzell TS, Huggins MA, Masopust D, Hamilton SE, Jameson SC.) Proc Natl Acad Sci U S A. 2022 Oct 25;119(43):e2209021119 PMID: 36260745 PMCID: PMC9618124 10/20/2022

• Mesothelium-Derived Factors Shape GATA6-Positive Large Cavity Macrophages.

  (Lai CW, Bagadia P, Barisas DAG, Jarjour NN, Wong R, Ohara T, Muegge BD, Lu Q, Xiong S, Edelson BT, Murphy KM, Stappenbeck TS.) J Immunol. 2022 Aug 15;209(4):742-750 PMID: 35868637 07/23/2022

• Epithelial STAT6 O-GlcNAcylation drives a concerted anti-helminth alarmin response dependent on tuft cell hyperplasia and Gasdermin C.

  (Zhao M, Ren K, Xiong X, Xin Y, Zou Y, Maynard JC, Kim A, Battist AP, Koneripalli N, Wang Y, Chen Q, Xin R, Yang C, Huang R, Yu J, Huang Z, Zhang Z, Wang H, Wang D, Xiao Y, Salgado OC, Jarjour NN, Hogquist KA, Revelo XS, Burlingame AL, Gao X, von Moltke J, Lin Z, Ruan HB.) Immunity. 2022 Jul 12;55(7):1327 PMID: 35830826 PMCID: PMC9336012 07/14/2022

• BHLHE40 Regulates the T-Cell Effector Function Required for Tumor Microenvironment Remodeling and Immune Checkpoint Therapy Efficacy.

  (Salmon AJ, Shavkunov AS, Miao Q, Jarjour NN, Keshari S, Esaulova E, Williams CD, Ward JP, Highsmith AM, Pineda JE, Taneja R, Chen K, Edelson BT, Gubin MM.) Cancer Immunol Res. 2022 May 03;10(5):597-611 PMID: 35181783 PMCID: PMC9164498 02/20/2022

• Engagement of the costimulatory molecule ICOS in tissues promotes establishment of CD8+ tissue-resident memory T cells.

  (Peng C, Huggins MA, Wanhainen KM, Knutson TP, Lu H, Georgiev H, Mittelsteadt KL, Jarjour NN, Wang H, Hogquist KA, Campbell DJ, Borges da Silva H, Jameson SC.) Immunity. 2022 Jan 11;55(1):98-114.e5 PMID: 34932944 PMCID: PMC8755622 12/22/2021