Yan-Qing Ma, PhD

Publications

• Kindlin-2 regulates hemostasis by controlling endothelial cell-surface expression of ADP/AMP catabolic enzymes via a clathrin-dependent mechanism.

  (Pluskota E, Ma Y, Bledzka KM, Bialkowska K, Soloviev DA, Szpak D, Podrez EA, Fox PL, Hazen SL, Dowling JJ, Ma YQ, Plow EF.) Blood. 2013 Oct 03;122(14):2491-9 PMID: 23896409 PMCID: PMC3790514 07/31/2013

• Integrity of kindlin-2 FERM subdomains is required for supporting integrin activation.

  (Xu Z, Gao J, Hong J, Ma YQ.) Biochem Biophys Res Commun. 2013 May 03;434(2):382-7 PMID: 23578664 04/13/2013

• Integrin αIIbβ3

  (Bledzka K, Pesho M and Ma Y.-Q. and Plow EF.) Platelets 3/e. Chapter 8, Michelson 2013 05/22/2014

• Spatial coordination of kindlin-2 with talin head domain in interaction with integrin β cytoplasmic tails.

  (Bledzka K, Liu J, Xu Z, Perera HD, Yadav SP, Bialkowska K, Qin J, Ma YQ, Plow EF.) J Biol Chem. 2012 Jul 13;287(29):24585-94 PMID: 22648415 PMCID: PMC3397883 06/01/2012

• Structural basis of phosphoinositide binding to kindlin-2 protein pleckstrin homology domain in regulating integrin activation.

  (Liu J, Fukuda K, Xu Z, Ma YQ, Hirbawi J, Mao X, Wu C, Plow EF, Qin J.) J Biol Chem. 2011 Dec 16;286(50):43334-42 PMID: 22030399 PMCID: PMC3234820 10/28/2011

• Membrane binding of the N-terminal ubiquitin-like domain of kindlin-2 is crucial for its regulation of integrin activation.

  (Perera HD, Ma YQ, Yang J, Hirbawi J, Plow EF, Qin J.) Structure. 2011 Nov 09;19(11):1664-71 PMID: 22078565 PMCID: PMC3217186 11/15/2011

• The integrin coactivator kindlin-2 plays a critical role in angiogenesis in mice and zebrafish.

  (Pluskota E, Dowling JJ, Gordon N, Golden JA, Szpak D, West XZ, Nestor C, Ma YQ, Bialkowska K, Byzova T, Plow EF.) Blood. 2011 May 05;117(18):4978-87 PMID: 21378273 PMCID: PMC3100704 03/08/2011

• Tyrosine phosphorylation of integrin beta3 regulates kindlin-2 binding and integrin activation.

  (Bledzka K, Bialkowska K, Nie H, Qin J, Byzova T, Wu C, Plow EF, Ma YQ.) J Biol Chem. 2010 Oct 01;285(40):30370-4 PMID: 20702409 PMCID: PMC2945529 08/13/2010

• The integrin co-activator Kindlin-3 is expressed and functional in a non-hematopoietic cell, the endothelial cell.

  (Bialkowska K, Ma YQ, Bledzka K, Sossey-Alaoui K, Izem L, Zhang X, Malinin N, Qin J, Byzova T, Plow EF.) J Biol Chem. 2010 Jun 11;285(24):18640-9 PMID: 20378539 PMCID: PMC2881789 04/10/2010