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Program in Chemical Biology

Medical College of Wisconsin Program in Chemical Biology

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The Program in Chemical Biology (PCB) provides resources in structure-based drug design and small molecule synthesis for chemical biology and medicinal chemistry projects. The PCB supports projects from numerous departments and centers across the MCW research enterprise and the scientific community at large. The PCB encourages investigators interested in the development and use of small molecules for basic and translational research to take advantage of its capabilities which span a range of biophysical methods for screening and quantitative analysis of binding, structural biology techniques. Major activities are organized into three teams, each of which is led by a PCB faculty member.


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Small Molecule Screening

The small molecule screening team uses NMR spectroscopy and other biophysical techniques to identify novel ligands for purified target proteins.

Contact Francis Peterson, team leader
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Synthetic Chemistry

The synthetic chemistry team leads the design, purchasing, and/or de novo synthesis of small molecules for chemical biology and medicinal chemistry projects.

Contact Brian Smith, team leader
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Structural Biology

The structural biology team assists with the experimental determination of protein-ligand complexes by X-ray crystallography, NMR spectroscopy, and computational modeling.

Contact Dawn Wenzel, team leader

Nominate your protein for screening

PCB employs a three-step process for screening campaigns: (1) target assessment, (2) primary screening, (3) hit validation and optimization. Investigators initiate a campaign by completing the candidate submission form, which gathers details about the screening target, including the name of the protein, structural details, and availability of purified protein.

Access screening form

To acknowledge the Program in Chemical Biology in publications:

This research was completed with support from the MCW Program in Chemical Biology, which was established with support from the Medical College of Wisconsin, the MCW Cancer Center, the Advancing a Healthier Wisconsin Endowment, and the Clinical & Translational Science Institute of Southeast Wisconsin.

Contact Us

Medical College of Wisconsin - Program in Chemical Biology
TBRC C0758
8701 Watertown Plank Rd.
Milwaukee, WI 53226