Zhongyuan Chen, PhD

Assistant Professor

Locations

Biostatistics
MEB M1401

Contact Information

Education

PhD, Statistics, Rice University, Houston, TX, 2019

Biography

Dr. Zhongyuan Chen is an assistant professor in the Division of Biostatistics at the Medical College of Wisconsin. She joined the division in May 2023. Previously, she held a position of a Visiting Assistant Professor in the Department of Statistics at Purdue University.

Dr. Chen’s main research interest is to integrate statistical methodology into other ﬁelds such as biosciences, cancer genomics and genetics, bioinformatics, and numerical computations. In particular, her work includes innovative strategies to apply statistical analysis, statistical methods, and machine learning strategies to high-dimensional data, practical medical and biological applications, and large-scale scientiﬁc computing tasks.

Some highlights of Dr. Chen’s work include the following: 1) statistical machine learning and dimension reduction for treatment recommendation (personalized medicine); causal inference: treatment effect estimation; 2) statistical methods and large-scale data analysis for cancer genomic and genetic data; 3) bioinformatics and computational biology for big data of cancer; and 4) statistical analysis for randomized algorithms; 5) high-dimensional causal inference under hidden confounding; Bayesian methodology/applications.

Dr. Chen has close collaborations with researchers across multiple disciplines beyond statistics, including cancer biology, mathematics, and bioinformatics. In particular, Dr. Chen collaborates with research groups in multiple cancer centers and medical schools such as MCW Cancer Center, MD Anderson Cancer Center, Baylor College of Medicine, and IU School of Medicine.

View Dr. Zhongyuan Chen's profile.

Data-adaptive and pathway-based tests for association studies between somatic mutations and germline variations in human cancers.

(Chen Z, Liang H, Wei P.) Genet Epidemiol. 2023 Dec;47(8):617-636 PMID: 37822029 10/12/2023
Estimating heterogeneous treatment effects versus building individualized treatment rules: Connection and disconnection

(Chen Z, Xie J.) Statistics and Probability Letters. August 2023;199 SCOPUS ID: 2-s2.0-85156220115 08/01/2023
DATA-GUIDED TREATMENT RECOMMENDATION WITH FEATURE SCORES

(Chen Z, Wang Z, Song Q, Xie J.) Statistica Sinica. 2022;32:2497-2519 SCOPUS ID: 2-s2.0-85140409203 01/01/2022
SRC-3 inhibition blocks tumor growth of pancreatic ductal adenocarcinoma.

(Song X, Chen H, Zhang C, Yu Y, Chen Z, Liang H, Van Buren G 2nd, McElhany AL, Fisher WE, Lonard DM, O'Malley BW, Wang J.) Cancer Lett. 2019 Feb 01;442:310-319 PMID: 30423406 PMCID: PMC6311429 11/14/2018
Comprehensive Molecular Characterization of the Hippo Signaling Pathway in Cancer.

(Wang Y, Xu X, Maglic D, Dill MT, Mojumdar K, Ng PK, Jeong KJ, Tsang YH, Moreno D, Bhavana VH, Peng X, Ge Z, Chen H, Li J, Chen Z, Zhang H, Han L, Du D, Creighton CJ, Mills GB, Cancer Genome Atlas Research Network, Camargo F, Liang H.) Cell Rep. 2018 Oct 30;25(5):1304-1317.e5 PMID: 30380420 PMCID: PMC6326181 11/01/2018
Molecular Characterization and Clinical Relevance of Metabolic Expression Subtypes in Human Cancers.

(Peng X, Chen Z, Farshidfar F, Xu X, Lorenzi PL, Wang Y, Cheng F, Tan L, Mojumdar K, Du D, Ge Z, Li J, Thomas GV, Birsoy K, Liu L, Zhang H, Zhao Z, Marchand C, Weinstein JN, Cancer Genome Atlas Research Network, Bathe OF, Liang H.) Cell Rep. 2018 Apr 03;23(1):255-269.e4 PMID: 29617665 PMCID: PMC5916795 04/05/2018
Integrated Genomic Analysis of the Ubiquitin Pathway across Cancer Types.

(Ge Z, Leighton JS, Wang Y, Peng X, Chen Z, Chen H, Sun Y, Yao F, Li J, Zhang H, Liu J, Shriver CD, Hu H, Cancer Genome Atlas Research Network, Piwnica-Worms H, Ma L, Liang H.) Cell Rep. 2018 Apr 03;23(1):213-226.e3 PMID: 29617661 PMCID: PMC5916807 04/05/2018
Immune Microenvironment in Microsatellite-Instable Endometrial Cancers: Hereditary or Sporadic Origin Matters.

(Pakish JB, Zhang Q, Chen Z, Liang H, Chisholm GB, Yuan Y, Mok SC, Broaddus RR, Lu KH, Yates MS.) Clin Cancer Res. 2017 Aug 01;23(15):4473-4481 PMID: 28264871 PMCID: PMC5540763 03/08/2017
A ROR1-HER3-lncRNA signalling axis modulates the Hippo-YAP pathway to regulate bone metastasis.

(Li C, Wang S, Xing Z, Lin A, Liang K, Song J, Hu Q, Yao J, Chen Z, Park PK, Hawke DH, Zhou J, Zhou Y, Zhang S, Liang H, Hung MC, Gallick GE, Han L, Lin C, Yang L.) Nat Cell Biol. 2017 Feb;19(2):106-119 PMID: 28114269 PMCID: PMC5336186 01/24/2017
Nectar protein content and attractiveness to Aedes aegypti and Culex pipiens in plants with nectar/insect associations.

(Chen Z, Kearney CM.) Acta Trop. 2015 Jun;146:81-8 PMID: 25792420 03/21/2015
Metabolic engineering and applications of plant carotenoid biosynthesis.

(Z. Chen, S. Lu, and J.-R. Huang. .) Chinese Bulletin of Life Sciences. 03/20/2011