David X. Zhang Lab
David X. Zhang, PhD
Associate Professor, Department of Medicine
xfzhang@mcw.edu
The overall emphasis of Dr. Zhang’s research is to understand signaling mechanisms in regulation of blood vessel reactivity and homeostasis under normal states as well as in diseases such as coronary artery disease (CAD), hypertension, and diabetes. The current research is focused on the vascular regulation by ion channels such as transient receptor potential (TRP) channels and K+ channels.
Yoshinori Nishijima
Research Associate
ynishijima@mcw.edu
My current research is focused on understanding the transient receptor potential vanilloid 4 channels to angiotensin II-induced impairment of vasodilation in animals and humans. I am also interested in the role of vascular smooth muscle potassium channels in hydrogen peroxide-induced vasodilation in human arterioles, in health and disease.
Sheng Cao
Postdoctoral Fellow
scao@mcw.edu
My current research is focused on determining whether arachidonic acid (AA) serves as a key upstream mediator of flow-mediated dilation (FMD) in human coronary arteriole (HCA) and define the molecular mechanisms by which AA activates the transient receptor potential vallinoid type 4 (TRPV4) channel in coronary endothelial cells.
Ankush Korishettar
Research Assistant
akorishettar@mcw.edu
My current research is focused on characterizing the function of smooth muscle TRPV1 ion channels in controlling the diameter of small blood vessels and whether they contribute to the vasoconstriction response elicited by physiological vasoconstrictors such as endothelin-1.
Recent Publications
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TRPV4 regulates matrix stiffness and TGFβ1-induced epithelial-mesenchymal transition.
(Sharma S, Goswami R, Zhang DX, Rahaman SO.) J Cell Mol Med. 2019 Feb;23(2):761-774.
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(Palygin O, Miller BS, Nishijima Y, Zhang DX, Staruschenko A, Sorokin A.) FASEB J. 2019 02;33(2):2636-2645.
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(Cao S, Anishkin A, Zinkevich NS, Nishijima Y, Korishettar A, Wang Z, Fang J, Wilcox DA, Zhang DX.) J Biol Chem. 2018 04 06;293(14):5307-5322.
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(Nishijima Y, Korishettar A, Chabowski DS, Cao S, Zheng X, Gutterman DD, Zhang DX.) Microcirculation. 2018 01;25(1).
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TRPV4 ion channel is a novel regulator of dermal myofibroblast differentiation.
(Sharma S, Goswami R, Merth M, Cohen J, Lei KY, Zhang DX, Rahaman SO.) Am J Physiol Cell Physiol. 2017 May 01;312(5):C562-C572.
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TRPV4 ION Channel Is Associated with Scleroderma.
(Goswami R, Cohen J, Sharma S, Zhang DX, Lafyatis R, Bhawan J, Rahaman SO.) J Invest Dermatol. 2017 04;137(4):962-965.
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(Nishijima Y, Cao S, Chabowski DS, Korishettar A, Ge A, Zheng X, Sparapani R, Gutterman DD, Zhang DX.) Circ Res. 2017 Feb 17;120(4):658-669.
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(Gebremedhin D, Zhang DX, Weihrauch D, Uche NN, Harder DR.) PLoS One. 2017;12(5):e0176796.
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(Gebremedhin D, Zhang DX, Carver KA, Rau N, Rarick KR, Roman RJ, Harder DR.) Prostaglandins Other Lipid Mediat. 2016 07;124:16-26.
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A novel TRPV4-specific agonist inhibits monocyte adhesion and atherosclerosis.
(Xu S, Liu B, Yin M, Koroleva M, Mastrangelo M, Ture S, Morrell CN, Zhang DX, Fisher EA, Jin ZG.) Oncotarget. 2016 Jun 21;7(25):37622-37635.
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(Baumgardt SL, Paterson M, Leucker TM, Fang J, Zhang DX, Bosnjak ZJ, Warltier DC, Kersten JR, Ge ZD.) Circ Heart Fail. 2016 Jan;9(1):e002424.
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(Ho WS, Zheng X, Zhang DX.) Br J Pharmacol. 2015 Nov;172(22):5251-64.