David X. Zhang Lab

David Zhang

David X. Zhang, PhD
Associate Professor, Department of Medicine
xfzhang@mcw.edu

The overall emphasis of Dr. Zhang’s research is to understand signaling mechanisms in regulation of blood vessel reactivity and homeostasis under normal states as well as in diseases such as coronary artery disease (CAD), hypertension, and diabetes. The current research is focused on the vascular regulation by ion channels such as transient receptor potential (TRP) channels and K+ channels.

Yoshinori Nishijima

Yoshinori Nishijima
Research Associate
ynishijima@mcw.edu

My current research is focused on understanding the transient receptor potential vanilloid 4 channels to angiotensin II-induced impairment of vasodilation in animals and humans. I am also interested in the role of vascular smooth muscle potassium channels in hydrogen peroxide-induced vasodilation in human arterioles, in health and disease.

Shengcao Zhanglab

Sheng Cao
Postdoctoral Fellow
scao@mcw.edu

My current research is focused on determining whether arachidonic acid (AA) serves as a key upstream mediator of flow-mediated dilation (FMD) in human coronary arteriole (HCA) and define the molecular mechanisms by which AA activates the transient receptor potential vallinoid type 4 (TRPV4) channel in coronary endothelial cells.

Ankush Korishettar

Ankush Korishettar
Research Assistant
akorishettar@mcw.edu

My current research is focused on characterizing the function of smooth muscle TRPV1 ion channels in controlling the diameter of small blood vessels and whether they contribute to the vasoconstriction response elicited by physiological vasoconstrictors such as endothelin-1.

Myocardin and Kv1 Channels: A Paradigm Shift in Treating Vascular Smooth Muscle Cell-Related Proliferative Disease?

(Zhang DX, Gutterman DD.) Arterioscler Thromb Vasc Biol. 2019 12;39(12):2454-2456 PMID: 31770031 PMCID: PMC6980742 SCOPUS ID: 2-s2.0-85075688768 11/27/2019
TRPV4 regulates matrix stiffness and TGFβ1-induced epithelial-mesenchymal transition.

(Sharma S, Goswami R, Zhang DX, Rahaman SO.) J Cell Mol Med. 2019 02;23(2):761-774 PMID: 30450767 PMCID: PMC6349341 SCOPUS ID: 2-s2.0-85056765656 11/20/2018
Endothelin receptor A and p66Shc regulate spontaneous Ca2+ oscillations in smooth muscle cells controlling renal arterial spontaneous motion.

(Palygin O, Miller BS, Nishijima Y, Zhang DX, Staruschenko A, Sorokin A.) FASEB J. 2019 02;33(2):2636-2645 PMID: 30303741 PMCID: PMC6338658 SCOPUS ID: 2-s2.0-85061064863 10/12/2018
Transient receptor potential vanilloid 4 (TRPV4) activation by arachidonic acid requires protein kinase A-mediated phosphorylation.

(Cao S, Anishkin A, Zinkevich NS, Nishijima Y, Korishettar A, Wang Z, Fang J, Wilcox DA, Zhang DX.) J Biol Chem. 2018 04 06;293(14):5307-5322 PMID: 29462784 PMCID: PMC5892583 SCOPUS ID: 2-s2.0-85045077479 02/21/2018
Shaker-related voltage-gated K+ channel expression and vasomotor function in human coronary resistance arteries.

(Nishijima Y, Korishettar A, Chabowski DS, Cao S, Zheng X, Gutterman DD, Zhang DX.) Microcirculation. 2018 01;25(1) PMID: 29161755 PMCID: PMC5760438 SCOPUS ID: 2-s2.0-85040240704 11/22/2017
TRPV4 ion channel is a novel regulator of dermal myofibroblast differentiation.

(Sharma S, Goswami R, Merth M, Cohen J, Lei KY, Zhang DX, Rahaman SO.) Am J Physiol Cell Physiol. 2017 May 01;312(5):C562-C572 PMID: 28249987 PMCID: PMC6105932 SCOPUS ID: 2-s2.0-85018753321 03/03/2017
TRPV4 ION Channel Is Associated with Scleroderma.

(Goswami R, Cohen J, Sharma S, Zhang DX, Lafyatis R, Bhawan J, Rahaman SO.) J Invest Dermatol. 2017 04;137(4):962-965 PMID: 27889423 SCOPUS ID: 2-s2.0-85015888580 11/28/2016
Contribution of KV1.5 Channel to Hydrogen Peroxide-Induced Human Arteriolar Dilation and Its Modulation by Coronary Artery Disease.

(Nishijima Y, Cao S, Chabowski DS, Korishettar A, Ge A, Zheng X, Sparapani R, Gutterman DD, Zhang DX.) Circ Res. 2017 Feb 17;120(4):658-669 PMID: 27872049 PMCID: PMC5315616 SCOPUS ID: 2-s2.0-85000399498 11/23/2016
Detection of TRPV4 channel current-like activity in Fawn Hooded hypertensive (FHH) rat cerebral arterial muscle cells.

(Gebremedhin D, Zhang DX, Weihrauch D, Uche NN, Harder DR.) PLoS One. 2017;12(5):e0176796 PMID: 28472069 PMCID: PMC5417564 SCOPUS ID: 2-s2.0-85019077900 05/05/2017
Expression of CYP 4A ω-hydroxylase and formation of 20-hydroxyeicosatetreanoic acid (20-HETE) in cultured rat brain astrocytes.

(Gebremedhin D, Zhang DX, Carver KA, Rau N, Rarick KR, Roman RJ, Harder DR.) Prostaglandins Other Lipid Mediat. 2016 07;124:16-26 PMID: 27174801 PMCID: PMC5287377 SCOPUS ID: 2-s2.0-84973896991 05/14/2016
A novel TRPV4-specific agonist inhibits monocyte adhesion and atherosclerosis.

(Xu S, Liu B, Yin M, Koroleva M, Mastrangelo M, Ture S, Morrell CN, Zhang DX, Fisher EA, Jin ZG.) Oncotarget. 2016 Jun 21;7(25):37622-37635 PMID: 27191895 PMCID: PMC5122337 SCOPUS ID: 2-s2.0-84978176831 10/23/2016
Chronic Co-Administration of Sepiapterin and L-Citrulline Ameliorates Diabetic Cardiomyopathy and Myocardial Ischemia/Reperfusion Injury in Obese Type 2 Diabetic Mice.

(Baumgardt SL, Paterson M, Leucker TM, Fang J, Zhang DX, Bosnjak ZJ, Warltier DC, Kersten JR, Ge ZD.) Circ Heart Fail. 2016 Jan;9(1):e002424 PMID: 26763290 PMCID: PMC4714787 SCOPUS ID: 2-s2.0-84955258675 01/15/2016

Cardiovascular Center

David X. Zhang Lab

Recent Publications