Iftikhar J. Kullo, MD

Publications

• Transformer patient embedding using electronic health records enables patient stratification and progression analysis.

  (Xian S, Grabowska ME, Kullo IJ, Luo Y, Smoller JW, Walunas TL, Wei WQ, Jarvik GP, Mooney SD, Crosslin DR.) NPJ Digit Med. 2025 Aug 14;8(1):521 PMID: 40813607 PMCID: PMC12354887 08/15/2025

• Data sharing in the PRIMED Consortium: Design, implementation, and recommendations for future policymaking.

  (Smith JL, Wong Q, Hornsby W, Conomos MP, Heavner BD, Kullo IJ, Psaty BM, Rich SS, Stilp AM, Tayo B, Zhang Y, Natarajan P, Nelson SC, Polygenic Risk Methods in Diverse Populations (PRIMED) Consortium Data Sharing Working Group, Polygenic Risk Methods in Diverse Populations (PRIMED) Consortium.) Am J Hum Genet. 2025 Aug 07;112(8):1754-1768 PMID: 40628271 PMCID: PMC12414661 07/09/2025

• Covering medical care costs for participants in the eMERGE Network: Challenges for equity and implementation.

  (Rasmussen-Torvik LJ, Bonini KE, Harr MH, Abbass MA, Bangash H, Bland HT, Boyd BM, Chung WK, Clayton EW, Cohen SJ, Connolly JJ, Gascoigne C, Hernandez V, Holm IA, Horike-Pyne M, Jarvik GP, Karlson EW, Kullo IJ, Limdi NA, Maradik ME, McNally EM, Perez E, Prows CA, Shaibi GQ, Weng C, Rowley RK, Peterson JF, Linder JE, Sabatello M.) Genet Med. 2025 Aug;27(8):101457 PMID: 40391568 PMCID: PMC12318664 05/20/2025

• Enhancing polygenic scores for cardiometabolic traits through tissue- and cell-type-specific functional annotations.

  (Norland K, Schaid DJ, Kullo IJ.) HGG Adv. 2025 Jul 10;6(3):100427 PMID: 40143549 PMCID: PMC12059674 03/27/2025

• Phenome-wide association study identifies multiple traits associated with a polygenic risk score for colorectal cancer.

  (Rosenthal EA, Wei WQ, Luo Y, Namjou-Khales B, Schaid DJ, Esplin ED, Lape M, Kottyan L, Pacheco JA, Weng C, Gordon AS, Kullo IJ, Crosslin DR, Grady WM, Hsu L, Peters U, Jarvik GP.) Hum Genomics. 2025 Jul 09;19(1):77 PMID: 40635049 PMCID: PMC12239365 07/10/2025

• Recognition and management of persistent chylomicronemia: A joint expert clinical consensus by the National Lipid Association and the American Society for Preventive Cardiology.

  (Saadatagah S, Larouche M, Naderian M, Nambi V, Brisson D, Kullo IJ, Duell PB, Michos ED, Shapiro MD, Watts GF, Gaudet D, Ballantyne CM.) Am J Prev Cardiol. 2025 Jun;22:100978 PMID: 40242365 PMCID: PMC12003024 04/17/2025

• Clonal Hematopoiesis of Indeterminate Potential in Chronic Coronary Disease: A Report From the ISCHEMIA Trials Biorepository.

  (Muller MA, Liu R, Shah F, Hu J, Held C, Kullo IJ, McManus BM, Wallentin L, Newby LK, Sidhu MS, Bangalore S, Reynolds HR, Hochman JS, Maron DJ, Ruggles KV, Berger JS, Newman JD.) Circ Genom Precis Med. 2025 Jun;18(3):e004921 PMID: 40207358 PMCID: PMC12403068 04/10/2025

• Common-variant and rare-variant genetic architecture of heart failure across the allele-frequency spectrum.

  (Lee DSM, Cardone KM, Zhang DY, Tsao NL, Abramowitz S, Sharma P, DePaolo JS, Conery M, Aragam KG, Biddinger K, Dikilitas O, Hoffman-Andrews L, Judy RL, Khan A, Kullo IJ, Puckelwartz MJ, Reza N, Satterfield BA, Singhal P, Penn Medicine Biobank, Arany Z, Cappola TP, Carruth ED, Day SM, Do R, Haggerty CM, Joseph J, McNally EM, Nadkarni G, Owens AT, Rader DJ, Ritchie MD, Sun YV, Voight BF, Levin MG, Damrauer SM.) Nat Genet. 2025 Apr;57(4):829-838 PMID: 40195560 PMCID: PMC12049093 04/08/2025

• Effect of Disclosing a Polygenic Risk Score for Coronary Heart Disease on Adverse Cardiovascular Events.

  (Naderian M, Hamed ME, Vaseem AA, Norland K, Dikilitas O, Teymourzadeh A, Bailey KR, Kullo IJ.) Circ Genom Precis Med. 2025 Apr;18(2):e004968 PMID: 40151934 03/28/2025

• Mixed-effects polygenic risk score Phenome-wide association study detects genetic correlation between colorectal cancer risk and phenotype data extracted from the electronic health record.

  (Rosenthal EA, Wei WQ, Luo Y, Namjou-Khales B, Schaid DJ, Esplin ED, Lape M, Kottyan L, Pacheco JAPA, Weng C, Gordon AS, Kullo IJ, Crosslin DR, Grady WM, Hsu L, Peters U, Jarvik GP.) medRxiv. 2025 Feb 28 PMID: 40061333 PMCID: PMC11888517 03/10/2025

• Recognition and management of persistent chylomicronemia: A Joint Expert Clinical Consensus by the National Lipid Association and the American Society for Preventive Cardiology.

  (Saadatagah S, Larouche M, Naderian M, Nambi V, Brisson D, Kullo IJ, Duell PB, Michos ED, Shapiro MD, Watts GF, Gaudet D, Ballantyne CM.) J Clin Lipidol. 2025;19(4):723-736 PMID: 40360374 05/14/2025

• Epidemiology and longitudinal course of chylomicronemia: Insights from NHANES and a large health care system.

  (Saadatagah S, Naderian M, Larouche M, Gaudet D, Kullo IJ, Ballantyne CM.) J Clin Lipidol. 2025;19(3):432-441 PMID: 40155283 03/29/2025